PLK1 as a potential drug target in cancer therapy

2004 ◽  
Vol 62 (4) ◽  
pp. 349-361 ◽  
Author(s):  
Kee Chuan Goh ◽  
Haishan Wang ◽  
Niefang Yu ◽  
Yifa Zhou ◽  
Yin Zheng ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Target ◽  
Potential Drug Target ◽  
Potential Drug

scholarly journals Highlighted STAT3 as a potential drug target for cancer therapy

BMB Reports ◽  
2019 ◽  
Vol 52 (7) ◽  
pp. 415-423 ◽  
Author(s):  
Haeri Lee ◽  
Ae Jin Jeong ◽  
Sang-Kyu Ye
Keyword(s):  
Cancer Therapy ◽  
Drug Target ◽  
Potential Drug Target ◽  
Potential Drug

scholarly journals CDK8-Novel Therapeutic Opportunities

2019 ◽  
Vol 12 (2) ◽  
pp. 92 ◽  
Author(s):  
Ingeborg Menzl ◽  
Agnieszka Witalisz-Siepracka ◽  
Veronika Sexl
Keyword(s):  
Prostate Cancer ◽  
Cancer Therapy ◽  
Drug Target ◽  
Potential Drug Target ◽  
Cyclin Dependent Kinase ◽  
Potential Drug ◽  
Biological Functions ◽  
Novel Treatment ◽  
Breast And Prostate Cancer ◽  
Novel Therapeutic

Improvements in cancer therapy frequently stem from the development of new small-molecule inhibitors, paralleled by the identification of biomarkers that can predict the treatment response. Recent evidence supports the idea that cyclin-dependent kinase 8 (CDK8) may represent a potential drug target for breast and prostate cancer, although no CDK8 inhibitors have entered the clinics. As the available inhibitors have been recently reviewed, we focus on the biological functions of CDK8 and provide an overview of the complexity of CDK8-dependent signaling throughout evolution and CDK8-dependent effects that may open novel treatment avenues.

Aurora B kinase: a potential drug target for cancer therapy

2021 ◽  
Author(s):  
Azaj Ahmed ◽  
Anas Shamsi ◽  
Taj Mohammad ◽  
Gulam Mustafa Hasan ◽  
Asimul Islam ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Drug Target ◽  
Aurora B ◽  
Potential Drug Target ◽  
Potential Drug ◽  
Aurora B Kinase ◽  
Kinase A

The Prokaryotic FAD Synthetase Family: A Potential Drug Target

2013 ◽  
Vol 19 (14) ◽  
pp. 2637-2648 ◽  
Author(s):  
Ana Serrano ◽  
Patricia Ferreira ◽  
Marta Martinez-Julvez ◽  
Milagros Medina
Keyword(s):  
Drug Target ◽  
Potential Drug Target ◽  
Potential Drug

Bacterial Polyphosphate Kinases Revisited: Role in Pathogenesis and Therapeutic Potential

2019 ◽  
Vol 20 (3) ◽  
pp. 292-301 ◽  
Author(s):  
Lalit Kumar Gautam ◽  
Prince Sharma ◽  
Neena Capalash
Keyword(s):  
Drug Target ◽  
Bacterial Infections ◽  
Therapeutic Potential ◽  
Wide Distribution ◽  
Medical Community ◽  
Polyphosphate Kinase ◽  
Potential Drug Target ◽  
Potential Drug ◽  
Resistant Strains ◽  
Structural Aspects

Bacterial infections have always been an unrestrained challenge to the medical community due to the rise of multi-drug tolerant and resistant strains. Pioneering work on Escherichia coli polyphosphate kinase (PPK) by Arthur Kornberg has generated great interest in this polyphosphate (PolyP) synthesizing enzyme. PPK has wide distribution among pathogens and is involved in promoting pathogenesis, stress management and susceptibility to antibiotics. Further, the absence of a PPK orthologue in humans makes it a potential drug target. This review covers the functional and structural aspects of polyphosphate kinases in bacterial pathogens. A description of molecules being designed against PPKs has been provided, challenges associated with PPK inhibitor design are highlighted and the strategies to enable development of efficient drug against this enzyme have also been discussed.

Molecular Docking with Trehalose-6 Phosphate Phosphatase: A Potential Drug Target of Filaral Parasite ‘Brugia malayi’

2011 ◽  
Vol 8 (4) ◽  
pp. 363-370 ◽  
Author(s):  
Lakshminarayanan Karthik ◽  
Palayam Malathy ◽  
Annie Trinitta ◽  
Krishnasamy Gunasekaran
Keyword(s):  
Molecular Docking ◽  
Drug Target ◽  
Brugia Malayi ◽  
Potential Drug Target ◽  
Potential Drug
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