Effects of notoginsenoside R1 on attenuating depressive behavior induced by chronic stress in rats through induction of PI3K / AKT / NF‐κB pathway

2021 ◽  
Author(s):  
Qiongqiong Zhan ◽  
Yanfeng Wu ◽  
Lin Liu
Keyword(s):  
Chronic Stress ◽  
Depressive Behavior

scholarly journals Depressive behavior and vascular dysfunction: a link between clinical depression and vascular disease?

2010 ◽  
Vol 108 (5) ◽  
pp. 1041-1051 ◽  
Author(s):  
Alexandre C. d'Audiffret ◽  
Stephanie J. Frisbee ◽  
Phoebe A. Stapleton ◽  
Adam G. Goodwill ◽  
Elsa Isingrini ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Vascular Disease ◽  
Chronic Stress ◽  
Vascular Dysfunction ◽  
Significant Risk ◽  
Chronic Mild Stress ◽  
Prior History ◽  
No Production ◽  
Mild Stress ◽  
Depressive Behavior

As chronic stress and depression have become recognized as significant risk factors for peripheral vascular disease in patients with no prior history of vasculopathy, we interrogated this relationship utilizing an established mouse model of chronic stress/depressive symptoms from behavioral research. Male mice were exposed to 8 wk of unpredictable chronic mild stress (UCMS; e.g., wet bedding, predator sound/smell, random disruption of light/dark cycle), with indexes of depressive behavior (coat status, grooming, and mobility) becoming exacerbated vs. controls. In vascular rings, constrictor (phenylephrine) and endothelium-independent dilator (sodium nitroprusside) responses were not different between groups, although endothelium-dependent dilation (methacholine) was attenuated with UCMS. Nitric oxide synthase (NOS) inhibition was without effect in UCMS but nearly abolished reactivity in controls, while cyclooxygenase inhibition blunted dilation in both. Combined blockade abolished reactivity in controls, although a significant dilation remained in UCMS that was abolished by catalase. Arterial NO production was attenuated by UCMS, although H2O2 production was increased. UCMS mice demonstrated an increased, although variable, insulin resistance and inflammation. However, while UCMS-induced vascular impairments were consistent, the predictive power of aggregate plasma levels of insulin, TNF-α, IL-1β, and C-reactive peptide were limited. However, when separated into tertiles with regard to vascular outcomes, insulin resistance and hypertension were predictive of the most severe vascular impairments. Taken together, these data suggest that aggregate insulin resistance, inflammation, and hypertension in UCMS mice are not robust predictors of vascular dysfunction, suggesting that unidentified mechanisms may be superior predictors of poor vascular outcomes in this model.

scholarly journals Extracellular vesicles from Gram-positive and Gram-negative probiotics remediate stress-induced depressive behavior in mice

2021 ◽  
Author(s):  
Juli Choi ◽  
Hyejin Kwon ◽  
Yoon-Keun Kim ◽  
Pyung-Lim Han
Keyword(s):  
Gut Microbiota ◽  
Chronic Stress ◽  
Extracellular Vesicles ◽  
16S Rrna Genes ◽  
Rrna Genes ◽  
Gram Positive ◽  
Depressive Behavior ◽  
Gram Negative ◽  
Induced Changes ◽  
The Brain

Abstract Chronic stress causes maladaptive changes in the brain that lead to depressive behavior. In the present study, we investigate whether chronic stress alters gut microbiota and whether specific mediators of probiotics remedies stress-induced maladaptive changes in the brain. Mice treated with daily 2-h restraint for 14 days (CRST) exhibit depressive-like behavior. Sequence readings of 16S rRNA genes prepared from fecal samples taken from CRST-treated mice suggest that chronic stress induces gut microbiota changes that are pronounced 14 days after the last restraint, relative to those that occur in the 14-day stress phase. The genus Lactobacillus is one such microbiota substantially changed following chronic stress. In contrast, post-stress treatment with extracellular vesicles (EVs) derived from the Gram-positive probiotic Lactobacillus plantarum are sufficient to ameliorate stress-induced depressive-like behavior. Interestingly, EVs from the Gram-positive probiotic Bacillus subtilis and EVs from the Gram-negative probiotic Akkermansia muciniphila also produce anti-depressive-like effects. While chronic stress decreases expression of MeCP2, Sirt1, and/or neurotrophic factors in the hippocampus, EVs from the selected probiotics differentially restore stress-induced changes of these factors. These results suggest that chronic stress produces persistent changes in gut microbiota composition, whereas EVs of certain probiotics can be used for treatment of stress-induced maladaptive changes.

Insulin-like growth factor 2 mitigates depressive behavior in a rat model of chronic stress

2015 ◽  
Vol 89 ◽  
pp. 318-324 ◽  
Author(s):  
Yan-Wei Luo ◽  
Yang Xu ◽  
Wen-Yu Cao ◽  
Xiao-Lin Zhong ◽  
Juan Duan ◽  
...  
Keyword(s):  
Growth Factor ◽  
Chronic Stress ◽  
Rat Model ◽  
Insulin Like Growth Factor ◽  
Depressive Behavior

scholarly journals Age-dependent effects of chronic stress on brain plasticity and depressive behavior

2008 ◽  
Vol 107 (2) ◽  
pp. 522-532 ◽  
Author(s):  
Erika Toth ◽  
Roman Gersner ◽  
Adi Wilf-Yarkoni ◽  
Hagit Raizel ◽  
Dalit E. Dar ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Brain Plasticity ◽  
Depressive Behavior ◽  
Age Dependent

HMGB1 mediates depressive behavior induced by chronic stress through activating the kynurenine pathway

2018 ◽  
Vol 72 ◽  
pp. 51-60 ◽  
Author(s):  
Bo Wang ◽  
Yong-Jie Lian ◽  
Wen-Jun Su ◽  
Wei Peng ◽  
Xin Dong ◽  
...  
Keyword(s):  
Chronic Stress ◽  
Kynurenine Pathway ◽  
Depressive Behavior

scholarly journals NADPH Oxidase Mediates Depressive Behavior Induced by Chronic Stress in Mice

2012 ◽  
Vol 32 (28) ◽  
pp. 9690-9699 ◽  
Author(s):  
J.-S. Seo ◽  
J.-Y. Park ◽  
J. Choi ◽  
T.-K. Kim ◽  
J.-H. Shin ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Chronic Stress ◽  
Depressive Behavior
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