Protective role of pigment epithelium-derived factor (PEDF) in early phase of experimental diabetic retinopathy

2009 ◽  
Vol 25 (7) ◽  
pp. 678-686 ◽  
Author(s):  
Yumiko Yoshida ◽  
Sho-Ichi Yamagishi ◽  
Takanori Matsui ◽  
Yuko Jinnouchi ◽  
Kei Fukami ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Early Phase ◽  
Pigment Epithelium ◽  
Protective Role ◽  
Pigment Epithelium Derived Factor

scholarly journals Mechanisms of PEDF-mediated protection against reactive oxygen species damage in diabetic retinopathy and neuropathy

2014 ◽  
Vol 222 (3) ◽  
pp. R129-R139 ◽  
Author(s):  
Mina Elahy ◽  
Swati Baindur-Hudson ◽  
Vinicius F Cruzat ◽  
Philip Newsholme ◽  
Crispin R Dass
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Diabetic Retinopathy ◽  
Neuroprotective Effect ◽  
Pigment Epithelium ◽  
Protective Role ◽  
Oxygen Species ◽  
Physiological Processes ◽  
Pigment Epithelium Derived Factor

Pigment epithelium-derived factor (PEDF) is a pluripotent glycoprotein belonging to the serpin family. PEDF can stimulate several physiological processes such as angiogenesis, cell proliferation, and survival. Oxidative stress plays an important role in the occurrence of diabetic retinopathy (DR), which is the major cause of blindness in young diabetic adults. PEDF plays a protective role in DR and there is accumulating evidence of the neuroprotective effect of PEDF. In this paper, we review the role of PEDF and the mechanisms involved in its antioxidative, anti-inflammatory, and neuroprotective properties.

Protective role of vitamin D against oxidative stress in diabetic retinopathy

2021 ◽  
Author(s):  
Maria Stella Valle ◽  
Cristina Russo ◽  
Lucia Malaguarnera
Keyword(s):  
Oxidative Stress ◽  
Vitamin D ◽  
Diabetic Retinopathy ◽  
Protective Role

Role of pigment epithelium-derived factor (PEDF) on arsenic-induced neuronal apoptosis

Chemosphere ◽  
2019 ◽  
Vol 215 ◽  
pp. 925-931 ◽  
Author(s):  
Wei Zhang ◽  
Xiaohui Cui ◽  
Yanhui Gao ◽  
Liyan Sun ◽  
Jing Wang ◽  
...  
Keyword(s):  
Neuronal Apoptosis ◽  
Pigment Epithelium ◽  
Pigment Epithelium Derived Factor

Role of Pigment Epithelium-Derived Factor (PEDF) in Photoreceptor Cell Protection

2001 ◽  
pp. 119-126
Author(s):  
Wei Cao ◽  
Joyce Tombran-Tink ◽  
Rajesh Elias ◽  
Steven Sezate ◽  
James F. McGinnis
Keyword(s):  
Photoreceptor Cell ◽  
Pigment Epithelium ◽  
Cell Protection ◽  
Pigment Epithelium Derived Factor

Protective effect of vitrectomy on the course of diabetic retinopathy: A case report

2020 ◽  
pp. 112067212096873
Author(s):  
Lorenzo Iuliano ◽  
Eleonora Corbelli ◽  
Francesco Bandello ◽  
Marco Codenotti
Keyword(s):  
Diabetic Retinopathy ◽  
Case Report ◽  
Protective Role ◽  
Panretinal Photocoagulation ◽  
Vascular Abnormalities ◽  
Vein Occlusion ◽  
History Of ◽  
Carotid Circulation

Purpose: To hypothesize the protective role of vitrectomy on the natural course of diabetic retinopathy. Methods: Case report. Results: A 66-year-old lady with a history of type 1 diabetes mellitus since the age of 10 was referred for evaluation. She received laser treatment in her left eye for proliferative diabetic retinopathy 6 years earlier, while her right eye underwent vitrectomy for retinal detachment 17 years before. Diabetic retinopathy was found to be substantially asymmetrical, as the vitrectomized right eye had only mild macular edema without significant vascular abnormalities, whereas the left eye had a complete confluent panretinal photocoagulation with advanced atrophic macular changes. Other reasons for this asymmetry, such as axial length disparity, carotid circulation impairment, or history of branch retinal vein occlusion, were not identified. Conclusions: Vitreous removal, performed for a reason other than diabetic retinopathy, may inhibit the retinal complications often associated with longstanding diabetes. Further clinical studies should be considered to ascertain such evidence.

Protein Kinase C β (PRKCB1) and pigment epithelium derived factor (PEDF) gene polymorphisms and Diabetic Retinopathy in a south Indian cohort

2010 ◽  
Vol 31 (1) ◽  
pp. 18-23 ◽  
Author(s):  
Satagopan Uthra ◽  
Rajiv Raman ◽  
Bickol N. Mukesh ◽  
Samuel A. Rajkumar ◽  
Padmaja Kumari R ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Gene Polymorphisms ◽  
Pigment Epithelium ◽  
Pigment Epithelium Derived Factor ◽  
Kinase C ◽  
South Indian
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