A Missense Variant Arg611Cys in LIPE which Encodes Hormone Sensitive Lipase Decreases Lipolysis and Increases Risk of Type 2 Diabetes in American Indians

2021 ◽  
Author(s):  
YL Muller ◽  
J Sutherland ◽  
AK Nair ◽  
C Koroglu ◽  
S Kobes ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
American Indians ◽  
Missense Variant ◽  
Hormone Sensitive Lipase ◽  
Hormone Sensitive

scholarly journals Null Mutation in Hormone-Sensitive Lipase Gene and Risk of Type 2 Diabetes

2014 ◽  
Vol 370 (24) ◽  
pp. 2307-2315 ◽  
Author(s):  
Jessica S. Albert ◽  
Laura M. Yerges-Armstrong ◽  
Richard B. Horenstein ◽  
Toni I. Pollin ◽  
Urmila T. Sreenivasan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Hormone Sensitive Lipase ◽  
Null Mutation ◽  
Lipase Gene ◽  
Hormone Sensitive

scholarly journals Hormone-sensitive lipase is reduced in the adipose tissue of patients with type 2 diabetes mellitus: influence of IL-6 infusion

Diabetologia ◽  
2004 ◽  
Vol 48 (1) ◽  
pp. 105-112 ◽  
Author(s):  
M. J. Watt ◽  
A. L. Carey ◽  
E. Wolsk-Petersen ◽  
F. B. Kraemer ◽  
B. Klarland Pedersen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Adipose Tissue ◽  
Hormone Sensitive Lipase ◽  
Hormone Sensitive

1715-P: Identifying Potentially Functional Variants in Regulatory Regions in KCNQ1 that Associate with Type 2 Diabetes in American Indians

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1715-P
Author(s):  
YUNHUA L. MULLER ◽  
SAMANTHA E. DAY ◽  
SAYUKO KOBES ◽  
WILLIAM C. KNOWLER ◽  
ROBERT L. HANSON ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
American Indians ◽  
Regulatory Regions ◽  
Functional Variants

1709-P: Assessing the Role of 211 “Established” Type 2 Diabetes Variants in American Indians

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1709-P
Author(s):  
ROBERT L. HANSON ◽  
LAUREN E. WEDEKIND ◽  
WEN-CHI HSUEH ◽  
SAYUKO KOBES ◽  
LESLIE J. BAIER ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
American Indians

673-P: Food Insecurity and Intervention Opportunities for American Indians and Alaska Natives with Type 2 Diabetes: A Qualitative Analysis

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 673-P
Author(s):  
SARAH A. STOTZ ◽  
STEVEN LOCKHART ◽  
ANGELA G. BREGA ◽  
KELLY R. MOORE
Keyword(s):  
Type 2 Diabetes ◽  
Qualitative Analysis ◽  
Food Insecurity ◽  
American Indians ◽  
Alaska Natives

scholarly journals Caregiving Stress Among American Indians With Type 2 Diabetes: The Importance of Awareness of Connectedness and Family Support

2018 ◽  
Vol 24 (4) ◽  
pp. 621-639 ◽  
Author(s):  
Ashleigh Coser ◽  
Kelley J. Sittner ◽  
Melissa L. Walls ◽  
Tina Handeland
Keyword(s):  
Mental Health ◽  
Type 2 Diabetes ◽  
Physical Health ◽  
Family Support ◽  
American Indians ◽  
Diabetes Management ◽  
Cumulative Exposure ◽  
Physical And Mental Health ◽  
Community Connectedness

American Indian (AI) communities experience a disproportionate rate of Type 2 diabetes (T2D) and cumulative exposure to stress. Although this link is well researched among various populations, it has not been examined among AI communities. Path analysis was used to examine a multiple-mediator model to explain how caregiver stress influences self-reported mental and physical health among 100 AI participants with T2D. Caregiver stress was negatively associated with physical and mental health. Physical health was positively associated with family/community connectedness and mental health was positively associated with both family support and connectedness. The relationship between caregiver stress and mental health was partially mediated by family/community connectedness; caregiver stress had no indirect effects on physical health via either hypothesized mediator. Findings demonstrate the importance of integrating individuals’ connection to family and community and its influence on caregiver stress and mental health in intervention programs targeting diabetes management and care among AI communities.

scholarly journals Type 2 diabetes management among older American Indians: beliefs, attitudes, and practices

2018 ◽  
Vol 25 (8) ◽  
pp. 1055-1071 ◽  
Author(s):  
R. Turner Goins ◽  
Jacqueline Jones ◽  
Mark Schure ◽  
Blythe Winchester ◽  
Vickie Bradley
Keyword(s):  
Type 2 Diabetes ◽  
American Indians ◽  
Diabetes Management ◽  
Attitudes And Practices
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