Fasting and post-prandial adipose tissue lipoprotein lipase and hormone-sensitive lipase in obesity and Type 2 diabetes

2011 ◽  
Vol 34 (5) ◽  
pp. e110-e114 ◽  
Author(s):  
G. Costabile ◽  
G. Annuzzi ◽  
L. Di Marino ◽  
C. De Natale ◽  
R. Giacco ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Lipoprotein Lipase ◽  
Hormone Sensitive Lipase ◽  
Hormone Sensitive ◽  
Adipose Tissue Lipoprotein Lipase

scholarly journals Adipose Tissue Lipoprotein Lipase and Hormone-Sensitive Lipase

1997 ◽  
Vol 17 (10) ◽  
pp. 2287-2292 ◽  
Author(s):  
Signy Reynisdottir ◽  
Bo Angelin ◽  
Dominique Langin ◽  
Hans Lithell ◽  
Mats Eriksson ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Lipoprotein Lipase ◽  
Hormone Sensitive Lipase ◽  
Hormone Sensitive ◽  
Adipose Tissue Lipoprotein Lipase

Lower Stearoyl-CoA Desaturase and Hormone Sensitive Lipase Gene Expression in Superficial Subcutaneous Adipose Tissue of Male, but Not Female, Patients with Type 2 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2054-P
Author(s):  
KÁLMÁN BÓDIS ◽  
JESPER LUNDBOM ◽  
TOMAS JELENIK ◽  
DANIEL F. MARKGRAF ◽  
ALEXANDER STROM ◽  
...  
Keyword(s):  
Gene Expression ◽  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Hormone Sensitive Lipase ◽  
Lipase Gene ◽  
Hormone Sensitive ◽  
Stearoyl Coa Desaturase ◽  
Subcutaneous Adipose

Postprandial regulation of blood lipids and adipose tissue lipoprotein lipase in type 2 diabetes patients and healthy control subjects

2003 ◽  
Vol 166 (2) ◽  
pp. 359-367 ◽  
Author(s):  
Jan W. Eriksson ◽  
Jonas Burén ◽  
Maria Svensson ◽  
Thomas Olivecrona ◽  
Gunilla Olivecrona
Keyword(s):  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Lipoprotein Lipase ◽  
Blood Lipids ◽  
Control Subjects ◽  
Healthy Control ◽  
Adipose Tissue Lipoprotein Lipase ◽  
Diabetes Patients

scholarly journals Hormone-sensitive lipase is reduced in the adipose tissue of patients with type 2 diabetes mellitus: influence of IL-6 infusion

Diabetologia ◽  
2004 ◽  
Vol 48 (1) ◽  
pp. 105-112 ◽  
Author(s):  
M. J. Watt ◽  
A. L. Carey ◽  
E. Wolsk-Petersen ◽  
F. B. Kraemer ◽  
B. Klarland Pedersen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Adipose Tissue ◽  
Hormone Sensitive Lipase ◽  
Hormone Sensitive

scholarly journals Effects of Physiological Hypercortisolemia on the Regulation of Lipolysis in Subcutaneous Adipose Tissue1

1998 ◽  
Vol 83 (2) ◽  
pp. 626-631 ◽  
Author(s):  
Jaswinder S. Samra ◽  
Mo L. Clark ◽  
Sandy M. Humphreys ◽  
Ian A. MacDonald ◽  
Peter A. Bannister ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Lipoprotein Lipase ◽  
Sodium Succinate ◽  
Hormone Sensitive Lipase ◽  
Whole Body ◽  
Constant Infusion ◽  
Nonesterified Fatty Acid ◽  
Significant Difference ◽  
Hormone Sensitive ◽  
Subcutaneous Adipose

Cortisol is known to increase whole body lipolysis, yet chronic hypercortisolemia results in increased fat mass. The main aim of the study was to explain these two apparently opposed observations by examining the acute effects of hypercortisolemia on lipolysis in subcutaneous adipose tissue and in the whole body. Six healthy subjects were studied on two occasions. On one occasion hydrocortisone sodium succinate was infused iv to induce hypercortisolemia (mean plasma cortisol concentrations, 1500 ± 100 vs. 335± 25 nmol/L; P < 0.001); on the other occasion (control study) no intervention was made. Lipolysis in the sc adipose tissue of the anterior abdominal wall was studied by measurement of arterio-venous differences, and lipolysis in the whole body was studied by constant infusion of[ 1,2,3-2H5]glycerol for measurement of the systemic glycerol appearance rate. Hypercortisolemia led to significantly increased arterialized plasma nonesterified fatty acid (NEFA; P < 0.01) and blood glycerol concentrations (P < 0.05), with an increase in systemic glycerol appearance (P < 0.05). However, in sc abdominal adipose tissue, hypercortisolemia decreased veno-arterialized differences for NEFA (P < 0.05) and reduced NEFA efflux (P < 0.05). This reduction was attributable to decreased intracellular lipolysis (P < 0.05), reflecting decreased hormone-sensitive lipase action in this adipose depot. Hypercortisolemia caused a reduction in arterialized plasma TAG concentrations (P < 0.05), but without a significant change in the local extraction of TAG (presumed to reflect the action of adipose tissue lipoprotein lipase). There was no significant difference in plasma insulin concentrations between the control and hypercortisolemia study. Site-specific regulation of the enzymes of intracellular lipolysis (hormone-sensitive lipase) and intravascular lipolysis (lipoprotein lipase) may explain the ability of acute cortisol treatment to increase systemic glycerol and NEFA appearance rates while chronically promoting net central fat deposition.

Seasonal changes in hormone-sensitive and lipoprotein lipase mRNA concentrations in marmot white adipose tissue

1992 ◽  
Vol 262 (2) ◽  
pp. R177-R181 ◽  
Author(s):  
B. E. Wilson ◽  
S. Deeb ◽  
G. L. Florant
Keyword(s):  
Adipose Tissue ◽  
Lipoprotein Lipase ◽  
White Adipose Tissue ◽  
Mass Gain ◽  
The Body ◽  
Hormone Sensitive Lipase ◽  
Marmota Flaviventris ◽  
Fasting Period ◽  
Hormone Sensitive ◽  
Clear Increase

White adipose tissue (WAT) and plasma samples were obtained from yellow-bellied marmots (Marmota flaviventris) throughout the year. Mean plasma triacylglycerol (TG), free fatty acids (FFAs), and glycerol were determined. There was a clear increase in FFAs and decrease in mean TG and glycerol during the hibernation period when animals were fasting, suggesting increased lipolysis. RNA was isolated from WAT biopsies at four times in the year: spring, summer, fall, and winter. There were significant changes in the relative levels of mRNA for lipoprotein lipase (LPL) and hormone-sensitive lipase (HSL) during the body mass cycle of the marmot. The relative levels of LPL mRNA are high during the mass gain phase of the year and that of HSL mRNA are high during the fasting period when endogenous lipid is utilized. These results suggest that the genes for LPL and HSL are regulated seasonally to control the adipose mass depot in marmots.

scholarly journals Messenger RNAs encoding lipoprotein lipase, fatty acid synthase and hormone-sensitive lipase in the adipose tissue of underfed-refed ewes and cows

1998 ◽  
Vol 38 (3) ◽  
pp. 297-307 ◽  
Author(s):  
Muriel Bonnet ◽  
Yannick Faulconnier ◽  
Jeanne Fléchet ◽  
Jean-François Hocquette ◽  
Christine Leroux ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
Lipoprotein Lipase ◽  
Fatty Acid Synthase ◽  
Hormone Sensitive Lipase ◽  
Messenger Rnas ◽  
Hormone Sensitive
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