Serum protein patterns in newly diagnosed type 2 diabetes mellitus—influence of diabetic environment and family history of diabetes

2008 ◽  
Vol 24 (2) ◽  
pp. 148-154 ◽  
Author(s):  
Tea Sundsten ◽  
Claes-Göran Östenson ◽  
Peter Bergsten
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Family History ◽  
Serum Protein ◽  
Newly Diagnosed ◽  
Protein Patterns ◽  
Family History Of Diabetes ◽  
History Of

Joint Effect of Family History of Diabetes with Obesity on Prevalence of Type 2 Diabetes Mellitus Among Chinese and Finnish Men and Women

2013 ◽  
Vol 37 (2) ◽  
pp. 65-71 ◽  
Author(s):  
Feng Ning ◽  
Zengchang Pang ◽  
Tiina Laatikainen ◽  
Weiguo Gao ◽  
Shaojie Wang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Family History ◽  
Joint Effect ◽  
Family History Of Diabetes ◽  
Men And Women ◽  
History Of

scholarly journals Coffee consumption and type 2 diabetes mellitus

Medicina ◽  
2009 ◽  
Vol 45 (1) ◽  
pp. 61
Author(s):  
Lina Radzevičienė ◽  
Rytas Ostrauskas
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Family History ◽  
Lower Risk ◽  
Conditional Logistic Regression ◽  
Coffee Consumption ◽  
Family History Of Diabetes ◽  
History Of

The aim of the study was to determine the association between coffee consumption and the risk of type 2 diabetes mellitus. Material and methods. A case-control study included 234 cases with newly confirmed diagnosis of type 2 diabetes mellitus and 468 controls who were free of the disease in 2001. Cases and controls were matched by gender and age (±5 years). Data on age, education level, occupation status, marital status, family history of diabetes, lifestyle (dietary habits, smoking habits, coffee consumption, alcohol consumption, physical activity), and stress were collected via a questionnaire. Variables were retained in models as confounders when their inclusion changed the value of the OR by more than 10% in any exposure category. Conditional logistic regression to compute the odds ratio (OR), 95% confidence interval (CI), and P for trend was used. Results. After adjustment for possible confounders (family history of diabetes, body mass index, eating speed, morning exercise, cigarette smoking, years of education, and stress), a statistically significant relationship was observed between type 2 diabetes mellitus and coffee consumption. Individuals consuming four or more cups of coffee per day were at lower risk of 2 diabetes mellitus (OR=0.51; 95% CI, 0.27–0.97) compared to those who consumed one or less than one cup of coffee per day. Conclusion. Habitual coffee consumption of four or more cups per day might be related to the lower risk of type 2 diabetes mellitus.

scholarly journals A Possible Early Alteration of Autonomic Activity Assessed by Heart Rate Variability in Saudi Offspring of Type 2 Diabetic Patients

2011 ◽  
Vol 1 (2) ◽  
pp. 17-23
Author(s):  
Daad H. Akbar ◽  
Maha A. Hegazi ◽  
Hanan A. Al Kadi ◽  
Maimona M. Ahmad
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Type 2 Diabetes Mellitus ◽  
Family History ◽  
Family History Of Diabetes ◽  
History Of

Background and Objectives: To evaluate cardiac autonomic function in non-diabetic offspring of Type 2 diabetes mellitus patients through assessment of heart rate variability. Autonomic dysfunction was reported in glucose tolerant on insulin-resistant offspring of Type 2 diabetes mellitus subjects. No data is available on cardiac autonomic dysfunction in Saudi offspring of Type 2 diabetes mellitus. Subject and Methods: Ninety-seven subjects with family history and 30 subjects with no family history of diabetes mellitus as a control group were studied. Anthropometric and biochemical characteristics (fasting blood glucose, lipids, and insulin resistance) were measured. Heart rate variability parameters were recorded. Results: No significant differences in the anthropometric, biochemical or heart rate variability parameters between the group with positive family history of diabetes mellitus and the control group. Subjects with positive family history of diabetes mellitus were split into 2 groups as per the presence or absence of insulin resistance. Insignificantly, an increased sympathetic tone was seen in Type 2 diabetes mellitus offspring with insulin resistance as compared to those without it. Body mass index, waist circumference, waist to hip ratio, total cholesterol, triglyceride, and fasting insulin and fasting blood glucose were also significantly higher in the insulin resistance group. Conclusion: There was a high prevalence of insulin resistance among the young subjects with positive family history of diabetes. Thus, had an increased sympathetic activity compared to those who were insulin sensitive. This study confirms the early autonomic dysfunction in offspring of Type 2 diabetes mellitus subjects previously reported in other non-Saudi populations.

scholarly journals A study of insulin resistance and pancreatic beta cell function in diabetics and non-diabetics

Biomedicine ◽  
2020 ◽  
Vol 39 (3) ◽  
pp. 497-502
Author(s):  
Mary Chandrika A. ◽  
B. Shanthi
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Family History ◽  
Pancreatic Beta Cell ◽  
Family History Of Diabetes ◽  
C Peptide ◽  
History Of

Introduction and Aim: The most common non-communicable disease affecting large population is type 2 diabetes mellitus. This metabolic disorder is characterized by hyperglycemia with disturbances of carbohydrate, fat and protein metabolism. The causes of diabetes mellitus can vary greatly but always include either defects in insulin secretion of the pancreas or the cells of the body not responding properly to the insulin produced or in both at some point in the course of the disease. Materials and Methods: 200 participants who were divided into two groups, non-diabetics with and without family history of diabetes were involved in this study. The outcomes of fasting plasma glucose, postprandial plasma glucose, glycated hemoglobin, fasting plasma insulin, serum c-peptide, HOMA -IR, HOMA-B were compared between both the groups. Results: All these parameters were significantly correlated between the groups with the level of significance p<0.05%. Non-diabetic off-springs of type 2 diabetes were found to have hyperinsulinemia, increased level of serum c-peptide level, moderate insulin resistance and pancreatic beta cell dysfunction than non-diabetics without the family history of diabetes. The fasting hyperinsulinemia, known to reflect decreased insulin sensitivity constitute the strongest independent predictor of type 2 diabetes. Conclusion: The above findings show that insulin resistance is the primary abnormality in type 2 Diabetes Mellitus.

scholarly journals A Possible Early Alteration of Autonomic Activity Assessed by Heart Rate Variability in Saudi Offspring of Type 2 Diabetic Patients

2011 ◽  
Vol 1 (2) ◽  
pp. 17-23
Author(s):  
Daad H. Akbar ◽  
Maha A. Hegazi ◽  
Hanan A. Al Kadi ◽  
Maimona M. Ahmad
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Type 2 Diabetes Mellitus ◽  
Family History ◽  
Family History Of Diabetes ◽  
History Of

Background and Objectives: To evaluate cardiac autonomic function in non-diabetic offspring of Type 2 diabetes mellitus patients through assessment of heart rate variability. Autonomic dysfunction was reported in glucose tolerant on insulin-resistant offspring of Type 2 diabetes mellitus subjects. No data is available on cardiac autonomic dysfunction in Saudi offspring of Type 2 diabetes mellitus. Subject and Methods: Ninety-seven subjects with family history and 30 subjects with no family history of diabetes mellitus as a control group were studied. Anthropometric and biochemical characteristics (fasting blood glucose, lipids, and insulin resistance) were measured. Heart rate variability parameters were recorded. Results: No significant differences in the anthropometric, biochemical or heart rate variability parameters between the group with positive family history of diabetes mellitus and the control group. Subjects with positive family history of diabetes mellitus were split into 2 groups as per the presence or absence of insulin resistance. Insignificantly, an increased sympathetic tone was seen in Type 2 diabetes mellitus offspring with insulin resistance as compared to those without it. Body mass index, waist circumference, waist to hip ratio, total cholesterol, triglyceride, and fasting insulin and fasting blood glucose were also significantly higher in the insulin resistance group. Conclusion: There was a high prevalence of insulin resistance among the young subjects with positive family history of diabetes. Thus, had an increased sympathetic activity compared to those who were insulin sensitive. This study confirms the early autonomic dysfunction in offspring of Type 2 diabetes mellitus subjects previously reported in other non-Saudi populations.

scholarly journals Clinical Symptoms Used for Screening Diabetic Populations with Family History of Type 2 Diabetes Mellitus

2018 ◽  
Vol 1 (2) ◽  
pp. 24
Author(s):  
Siti Marlina ◽  
I Dewa Putu Pramantara ◽  
Hari J. Kusnanto ◽  
Mark Alan Graber
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Family History ◽  
Clinical Symptoms ◽  
Fasting Blood Glucose ◽  
Family History Of Diabetes ◽  
Birth History ◽  
History Of

Background: The annual prevalence of diabetes is increasing worldwide. With this growing concern, the identification of clinical symptoms in high risk populations, such as those with a family history of diabetes, is becoming increasingly important.Objectives: This study aimed to determine the use of clinical symptoms and history as a screening tool for diabetes mellitus (DM) in a population with a family history of Type 2 Diabetes Mellitus (T2DM).Methods: The design of this research was a cross sectional study. The subjects of this study were a sample population with family history of T2DM living in Kasihan and Sewon District of Bantul Regency. Data were collected through interviews with questionnaires, anthropometric measurements, total cholesterol tests, triglycerides and fasting blood glucose tests. Data analysis used univariate, bivariate and multivariate analyses. For screening purposes, validity was performed against risk factors with fasting blood glucose as a gold standard.Results: Prevalence of DM was 30.5%, and prediabetes 26.5%. Body Mass Index (BMI) prevalence =23 kg/m2 59.02%, hypertension 42.62%, physical inactivity 21.31%, and dyslipidemia 78.69%. Polyuria, polydipsia, and weight loss were significantly associated with T2DM. Birth history of weight =4 kg or Gestational Diabetes Mellitus (GDM) was a risk factor associated with T2DM incidence (p = 0.018; OR: 1.93; CI 95%: 1.12-3.34). The sensitivity of a combination of several factors, birth history of baby =4 kg or GDM with dyslipidemia (sensitivity 87.3% specificity 40.9%), birth history of weight =4 kg or GDM with dyslipidemia and hypertension (sensitivity 94.7% specificity 26.7%), combination of the five factors studied (sensitivity 92.3% specificity 50%). Combination of birth history of heavy baby =4kg or GDM and BMI = 23 kg/m2  and hypertension had a likelihood ratio of 9.Conclusions: This study determined the prevalence of T2DM in populations with a family history of diabetes is high, with birth history of weight = 4 kg or GDM as a factor associated with T2DM, and other clinical symptoms having a fairly high prevalence. Therefore, a comprehensive lifestyle change needs to be done.

PREDICTION OF TYPE 2 DIABETES MELLITUS BY FINDRISC ON PRE-DIABETES PATIENTS OVER 45 YEARS OLD

2012 ◽  
pp. 20-29
Author(s):  
Van Vy Hau Nguyen ◽  
Hai Thuy Nguyen
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Family History ◽  
Waist Circumference ◽  
Undiagnosed Diabetes ◽  
Oral Glucose ◽  
Family History Of Diabetes ◽  
History Of

Objectives: To predict the risk of type 2 diabetes mellitus (T2DM) in ten years by applying FINDRISC. Methods: 131 patients were diagnosed pre-diabetes according to the ADA (2010) criteria using fasting plasma glucose, 2h after 75g oral glucose load and/or HbA1c. FINDRISC includes eight parameters: age, abdominal obesity, waist circumference, family history of diabetes, physical activity, history of increased glucose and using of anti-hypertensive medications and eating habit of vegetables fruits or berries. Results: In the eight element of FINDRISC, BMI and waist circumference, family history of diabetes, history of hypertension and antihypertensive drug use are risk factors are most important. The area under the curve order is 0.912; 0.879; 0.819; 0.720 and 0.664 respectively. Application FINDRISC- South Asian we recorded the optimal cut points 9 points (Se = 0.61, Sp = 0.85, p <0.001) to detect pre-diabetes and 15 points (Se = 1.00 and Sp=0.91, p< 0.0001) to detect diabetes. Risk of diabetes in 10 years by using FINDRISC-Asian scale is higher than using FINDRISC- European scale: 7.68% vs 4.91% in men, 9.64% vs 8.17% in female and 8.74% vs 6.68% for both sexes, respectively. Conclusion: We can use FINDRISC to predict the risk of type 2 diabetes mellitus, and screening type 2 undiagnosed diabetes mellitus in Vietnam if the BMI and waist circumference are change criteria for South Asia.

scholarly journals Family history of diabetes, lifestyle factors, and the 7-year incident risk of type 2 diabetes mellitus in middle-aged Japanese men and women

2013 ◽  
Vol 4 (3) ◽  
pp. 261-268 ◽  
Author(s):  
Masaru Sakurai ◽  
Koshi Nakamura ◽  
Katsuyuki Miura ◽  
Toshinari Takamura ◽  
Katsushi Yoshita ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Family History ◽  
Middle Aged ◽  
Japanese Men ◽  
Family History Of Diabetes ◽  
Men And Women ◽  
History Of

scholarly journals Risk Factors Associated with Diabetes Mellitus in Local Population of Lahore, Pakistan

2017 ◽  
Vol 9 (9) ◽  
pp. 42
Author(s):  
Sana Arshad ◽  
Sania Tahir ◽  
Bilal Tahir ◽  
Nazia Tahir ◽  
Tahir Rasool ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Body Mass Index ◽  
Type 2 Diabetes Mellitus ◽  
Family History ◽  
Local Population ◽  
Family History Of Diabetes ◽  
History Of

BACKGROUND: Diabetes is the leading cause of morbidity and mortality amongst the people of Pakistan. In 2015, 7 million people had diabetes and the number is still on raise. Family history of diabetes, high body mass index, and other sociodemographic factors are the risk factors of diabetes. Persistent exposure to excessive glucose may be a reason behind diabetic complications like nephropathy, neuropathy, retinopathy, cardiomyopathy and gestational diabetes mellitus.METHODS: For the evaluation of laboratory parameters, 600 blood samples were collected at Akhuwat Diabetic Centre and from Jinnah Hospital, Lahore. Demographic data of the participants was collected by filling a questionnaire. Lipid profile, liver enzymes, and renal function tests were performed and statistical analysis was done.RESULTS: Type 2 diabetes mellitus among other types is the most prevalent form of diabetes in our population. Family history of diabetes (p=0.002), Body Mass Index (&gt;25) p&lt;0.001, high cholesterol (p=0.04), high triglyceride p&lt;0.001, high LDL p&lt;0.001 and low HDL p&lt;0.001 are significantly associated with the incidence of diabetes. Hypertension among the other comorbidities is more common in diabetic patients.CONCLUSION: Type 2 Diabetes Mellitus is highly prevalent in the local population. Improved lifestyle and proper medical monitoring can help to manage diabetes in our population.

Sign in / Sign up

Export Citation Format

Share Document