Development of an Analytical Methodology for the Qualitative and Quantitative Characterization of Capsules with Andarine, in Order to Use them to Investigate the Pharmacotoxicological Profile of the Substance

2019 ◽  
Vol 70 (8) ◽  
pp. 2759-2763
Author(s):  
Amalia Miklos ◽  
Amelia Tero Vescan ◽  
Lenard Farczadi ◽  
Silvia Imre ◽  
Camil Eugen Vari ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
The Internet ◽  
Mass Content ◽  
European Pharmacopoeia ◽  
Quantitative Characterization ◽  
Analytical Methodology ◽  
Qualitative And Quantitative ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators

Andarine is one of the most commonly used doping substance between selective androgen receptor modulators (SARMs). The purpose of our study is to characterize qualitatively and quantitatively andarine capsules purchased legally via the Internet through a rapid and precise UHPLC method and the uniformity of mass, content and dissolution assays were determined following the methodology of the European Pharmacopoeia 8th Ed. Regarding the uniformity of mass, the capsules are within the permissible limits, but regarding the active substance content, an average of 4.99 mg of andarine/capsule was obtained (with an RSD of 5.41%) from the 25 mg/capsule declared by the manufacturer.

scholarly journals Chemical Composition and Labeling of Substances Marketed as Selective Androgen Receptor Modulators and Sold via the Internet

JAMA ◽  
2017 ◽  
Vol 318 (20) ◽  
pp. 2004 ◽  
Author(s):  
Ryan M. Van Wagoner ◽  
Amy Eichner ◽  
Shalender Bhasin ◽  
Patricia A. Deuster ◽  
Daniel Eichner
Keyword(s):  
Androgen Receptor ◽  
Chemical Composition ◽  
The Internet ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators

Characterization of equine urinary metabolites of selective androgen receptor modulators (SARMs) S1, S4 and S22 for doping control purposes

2015 ◽  
Vol 7 (8) ◽  
pp. 673-683 ◽  
Author(s):  
Annelie Hansson ◽  
Heather Knych ◽  
Scott Stanley ◽  
Mario Thevis ◽  
Ulf Bondesson ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Urinary Metabolites ◽  
Doping Control ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators

Characterization of In Vitro Synthesized Equine Metabolites of the Selective Androgen Receptor Modulators S24 and S4

2012 ◽  
Vol 32 (9) ◽  
pp. 562-568 ◽  
Author(s):  
Oliver Krug ◽  
Andreas Thomas ◽  
Simon Beuck ◽  
Ina Schenk ◽  
Marc Machnik ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators

Synthesis, Structure−Activity Relationships, and Characterization of Novel Nonsteroidal and Selective Androgen Receptor Modulators

2009 ◽  
Vol 52 (22) ◽  
pp. 7186-7191 ◽  
Author(s):  
Nathalie Schlienger ◽  
Birgitte W. Lund ◽  
Jan Pawlas ◽  
Fabrizio Badalassi ◽  
Fabio Bertozzi ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators

scholarly journals Design, Synthesis, and Biological Characterization of Metabolically Stable Selective Androgen Receptor Modulators

2004 ◽  
Vol 47 (4) ◽  
pp. 993-998 ◽  
Author(s):  
Craig A. Marhefka ◽  
Wenqing Gao ◽  
Kiwon Chung ◽  
Juhyun Kim ◽  
Yali He ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Biological Characterization ◽  
Design Synthesis ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators

scholarly journals Graphene, an Interesting Nanocarbon Allotrope for Biosensing Applications: Advances, Insights, and Prospects

2021 ◽  
Vol 12 ◽  
pp. 117959722098382
Author(s):  
Farid Menaa ◽  
Yazdian Fatemeh ◽  
Sandeep K Vashist ◽  
Haroon Iqbal ◽  
Olga N Sharts ◽  
...  
Keyword(s):  
Cost Effective ◽  
Genetic Alterations ◽  
Multiplex Detection ◽  
Quantitative Characterization ◽  
Disease Biomarkers ◽  
Qualitative And Quantitative ◽  
Sensing Systems ◽  
Doped Graphene ◽  
Bioanalytical Applications

Graphene, a relatively new two-dimensional (2D) nanomaterial, possesses unique structure (e.g. lighter, harder, and more flexible than steel) and tunable physicochemical (e.g. electronical, optical) properties with potentially wide eco-friendly and cost-effective usage in biosensing. Furthermore, graphene-related nanomaterials (e.g. graphene oxide, doped graphene, carbon nanotubes) have inculcated tremendous interest among scientists and industrials for the development of innovative biosensing platforms, such as arrays, sequencers and other nanooptical/biophotonic sensing systems (e.g. FET, FRET, CRET, GERS). Indeed, combinatorial functionalization approaches are constantly improving the overall properties of graphene, such as its sensitivity, stability, specificity, selectivity, and response for potential bioanalytical applications. These include real-time multiplex detection, tracking, qualitative, and quantitative characterization of molecules (i.e. analytes [H2O2, urea, nitrite, ATP or NADH]; ions [Hg2+, Pb2+, or Cu2+]; biomolecules (DNA, iRNA, peptides, proteins, vitamins or glucose; disease biomarkers such as genetic alterations in BRCA1, p53) and cells (cancer cells, stem cells, bacteria, or viruses). However, there is still a paucity of comparative reports that critically evaluate the relative toxicity of carbon nanoallotropes in humans. This manuscript comprehensively reviews the biosensing applications of graphene and its derivatives (i.e. GO and rGO). Prospects and challenges are also introduced.

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