scholarly journals Zika virus can directly infect and damage the auditory and vestibular components of the embryonic chicken inner ear

2020 ◽  
Vol 249 (7) ◽  
pp. 867-883
Author(s):  
Ankita Thawani ◽  
Nabilah H. Sammudin ◽  
Hannah S. Reygaerts ◽  
Alexis N. Wozniak ◽  
Vidhya Munnamalai ◽  
...  
Keyword(s):  
Inner Ear ◽  
Zika Virus ◽  
Embryonic Chicken

scholarly journals Shaping of inner ear sensory organs through antagonistic interactions between Notch signalling and Lmx1a

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Zoe F Mann ◽  
Héctor Gálvez ◽  
David Pedreno ◽  
Ziqi Chen ◽  
Elena Chrysostomou ◽  
...  
Keyword(s):  
Inner Ear ◽  
Notch Signalling ◽  
Sensory Organ ◽  
Sensory Organs ◽  
Functional Diversification ◽  
Dynamic Nature ◽  
Embryonic Chicken ◽  
Mechanisms Of Formation ◽  
Sensory Patch ◽  
Antagonistic Interactions

The mechanisms of formation of the distinct sensory organs of the inner ear and the non-sensory domains that separate them are still unclear. Here, we show that several sensory patches arise by progressive segregation from a common prosensory domain in the embryonic chicken and mouse otocyst. This process is regulated by mutually antagonistic signals: Notch signalling and Lmx1a. Notch-mediated lateral induction promotes prosensory fate. Some of the early Notch-active cells, however, are normally diverted from this fate and increasing lateral induction produces misshapen or fused sensory organs in the chick. Conversely Lmx1a (or cLmx1b in the chick) allows sensory organ segregation by antagonizing lateral induction and promoting commitment to the non-sensory fate. Our findings highlight the dynamic nature of sensory patch formation and the labile character of the sensory-competent progenitors, which could have facilitated the emergence of new inner ear organs and their functional diversification in the course of evolution.

scholarly journals Zika virus infection causes widespread damage to the inner ear

2020 ◽  
Vol 395 ◽  
pp. 108000
Author(s):  
Kathleen T. Yee ◽  
Biswas Neupane ◽  
Fengwei Bai ◽  
Douglas E. Vetter
Keyword(s):  
Virus Infection ◽  
Inner Ear ◽  
Zika Virus ◽  
Zika Virus Infection

Genetic Manipulation of the Embryonic Chicken Inner Ear

2022 ◽  
pp. 59-75
Author(s):  
Nicolas Daudet ◽  
Magdalena Żak ◽  
Thea Stole ◽  
Stephen Terry
Keyword(s):  
Inner Ear ◽  
Genetic Manipulation ◽  
Embryonic Chicken

scholarly journals Artificial Induction of Sox21 Regulates Sensory Cell Formation in the Embryonic Chicken Inner Ear

PLoS ONE ◽  
2012 ◽  
Vol 7 (10) ◽  
pp. e46387 ◽  
Author(s):  
Stephen D. Freeman ◽  
Nicolas Daudet
Keyword(s):  
Inner Ear ◽  
Sensory Cell ◽  
Cell Formation ◽  
Embryonic Chicken ◽  
Artificial Induction

scholarly journals Zika Virus Can Strongly Infect and Disrupt Secondary Organizers in the Ventricular Zone of the Embryonic Chicken Brain

Cell Reports ◽  
2018 ◽  
Vol 23 (3) ◽  
pp. 692-700 ◽  
Author(s):  
Ankita Thawani ◽  
Devika Sirohi ◽  
Richard J. Kuhn ◽  
Donna M. Fekete
Keyword(s):  
Zika Virus ◽  
Ventricular Zone ◽  
Chicken Brain ◽  
Embryonic Chicken

Otoconia formation in the chick embryo

1983 ◽  
Vol 41 ◽  
pp. 572-573
Author(s):  
C.D. Fermin ◽  
M. Igarashi
Keyword(s):  
Chick Embryo ◽  
Inner Ear ◽  
Gallus Domesticus ◽  
The Body ◽  
Abnormal Behavior ◽  
Intensive Study ◽  
Basic Fuchsin ◽  
Gestational Period ◽  
Sensory Epithelia ◽  
Transmission Electron

Otoconia are microscopic geometric structures that cover the sensory epithelia of the utricle and saccule (gravitational receptors) of mammals, and the lagena macula of birds. The importance of otoconia for maintanance of the body balance is evidenced by the abnormal behavior of species with genetic defects of otolith. Although a few reports have dealt with otoconia formation, some basic questions remain unanswered. The chick embryo is desirable for studying otoconial formation because its inner ear structures are easily accessible, and its gestational period is short (21 days of incubation).The results described here are part of an intensive study intended to examine the morphogenesis of the otoconia in the chick embryo (Gallus- domesticus) inner ear. We used chick embryos from the 4th day of incubation until hatching, and examined the specimens with light (LM) and transmission electron microscopy (TEM). The embryos were decapitated, and fixed by immersion with 3% cold glutaraldehyde. The ears and their parts were dissected out under the microscope; no decalcification was used. For LM, the ears were embedded in JB-4 plastic, cut serially at 5 micra and stained with 0.2% toluidine blue and 0.1% basic fuchsin in 25% alcohol.

Researchers Use Gene Therapy to Repair Inner-Ear Defects in Mice

ASHA Leader ◽  
2016 ◽  
Vol 21 (2) ◽  
Keyword(s):  
Gene Therapy ◽  
Inner Ear

Control of the Microcirculation of the Inner Ear

1975 ◽  
Vol 8 (2) ◽  
pp. 455-466 ◽  
Author(s):  
James B. Snow ◽  
Fumiro Suga
Keyword(s):  
Inner Ear

Normal and Abnormal Physiology of the Inner Ear

1975 ◽  
Vol 8 (2) ◽  
pp. 271-281 ◽  
Author(s):  
Brian Johnstone
Keyword(s):  
Inner Ear
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