scholarly journals Prognostic impact of left atrial function in heart failure with preserved ejection fraction in sinus rhythm vs. persistent atrial fibrillation

2021 ◽  
Author(s):  
Robert Schönbauer ◽  
Andreas A. Kammerlander ◽  
Franz Duca ◽  
Stefan Aschauer ◽  
Matthias Koschutnik ◽  
...  
2021 ◽  
Vol 05 (03) ◽  
Author(s):  
Mingxue Sun ◽  
Zhiyuan Shui ◽  
Yunzhi Wang ◽  
Yiqun Gao ◽  
Shunji Liang ◽  
...  

2014 ◽  
Vol 16 (10) ◽  
pp. 1096-1103 ◽  
Author(s):  
Angela B.S. Santos ◽  
Elisabeth Kraigher-Krainer ◽  
Deepak K. Gupta ◽  
Brian Claggett ◽  
Michael R. Zile ◽  
...  

2020 ◽  
Vol 22 (3) ◽  
pp. 472-485 ◽  
Author(s):  
Muhammad Shahzeb Khan ◽  
Muhammad Mustafa Memon ◽  
Mohammad H. Murad ◽  
Muthiah Vaduganathan ◽  
Stephen J. Greene ◽  
...  

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Shiro Hoshida ◽  
Yukinori Shinoda ◽  
koichi tachibana ◽  
Tomoko Minamisaka ◽  
Takahisa Yamada ◽  
...  

Objective: We aimed to clarify the differences in the significance of the ratio of diastolic elastance (Ed) to arterial elastance (Ea), [Ed/Ea=(E/e’)/(0.9 х systolic blood pressure)], a relative index of left atrial (LA) pressure overload, in relation to N-terminal pro-brain natriuretic peptide (NT-proBNP) level on prognosis between patients with heart failure with preserved ejection fraction (HFpEF) with and without atrial fibrillation (AF). Methods: We studied 297 HFpEF patients hospitalized for acute decompensated heart failure (sinus rhythm/AF: 192/105). Blood testing and transthoracic echocardiography were performed before discharge. All-cause mortality was evaluated at >1 year after discharge. Results: During a median follow-up of 626 days, 47 patients (sinus rhythm/AF: 30/17) had all-cause mortality. In the subgroup with sinus rhythm, but not AF, Ed/Ea was significantly higher in patients with than without all-cause mortality. In a multivariate Cox hazard analysis, Ed/Ea was significantly associated with all-cause mortality independent of NT-proBNP in patients with sinus rhythm, but not with AF. Among patients with higher NT-proBNP levels, the effect of higher Ed/Ea on prognosis was prominent only in those with sinus rhythm (p=0.037). Conclusions: Ed/Ea provides additional prognostic information to serum NT-proBNP level for predicting all-cause mortality only in HFpEF patients with sinus rhythm. The prognostic risk factors differed between elderly HFpEF patients with and without AF.


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