Immune recognition of tumor cellsin vivo. I. Role of H-2 gene products in T lymphocyte activation against minor histocompatibility antigens displayed by adenocarcinoma cells

1982 ◽  
Vol 12 (8) ◽  
pp. 664-670 ◽  
Author(s):  
Guido Forni ◽  
Santo Landolfo ◽  
Mirella Giovarelli ◽  
Alan C. Whitmore ◽  
Ronald B. Herberman
1983 ◽  
Vol 69 (5) ◽  
pp. 403-408
Author(s):  
Guido Forni ◽  
Luisa Lanfrancone ◽  
Mirella Giovarelli

The resistance of normal BALB/c mice (H-2d) against the L1210 Ha leukemia of DBA/2 mouse (H-2d) origin is due to the T-lymphocyte-dependent reaction towards DBA/2 multiple minor histocompatibility antigens (Mhas). These Mhas are displayed by the leukemic cells, though in a poorly immunogenic manner. The simultaneous presence of mitomycin C-inactivated DBA/2 leukocytes induces a significantly stronger T-lymphocyte-dependent reaction. This efficient presentation of target Mhas is restricted to Ia+ leukocytes. Their presence significantly increases BALB/c resistance, even when they are injected 3 days after the L1210 Ha challenge.


PLoS ONE ◽  
2017 ◽  
Vol 12 (10) ◽  
pp. e0185819 ◽  
Author(s):  
Renata Sesti-Costa ◽  
Marcela Cristina Santiago Françozo ◽  
Grace Kelly Silva ◽  
José Luiz Proenca-Modena ◽  
João Santana Silva

2009 ◽  
Vol 21 (8) ◽  
pp. 1298-1307 ◽  
Author(s):  
David M. Conrad ◽  
Suzanne J. Furlong ◽  
Carolyn D. Doucette ◽  
Robert T.M. Boudreau ◽  
David W. Hoskin

2000 ◽  
Vol 165 (8) ◽  
pp. 4718-4724 ◽  
Author(s):  
Catherine M. Greene ◽  
Gerard Meachery ◽  
Clifford C. Taggart ◽  
Cyril P. Rooney ◽  
Raymond Coakley ◽  
...  

2002 ◽  
Vol 14 (10) ◽  
pp. 849-859 ◽  
Author(s):  
Peihong Ma ◽  
Maureen Magut ◽  
Douglas V Faller ◽  
Chang-Yan Chen

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