Human antigen-specific memory T cells express the homing receptor (LAM-1) necessary for lymphocyte recirculation

1990 ◽  
Vol 20 (6) ◽  
pp. 1351-1355 ◽  
Author(s):  
Thomas F. Tedder ◽  
Takami Matsuyama ◽  
David Rothstein ◽  
Stuart F. Schlossman ◽  
Chikao Morimoto
Keyword(s):  
T Cells ◽  
Memory T Cells ◽  
Homing Receptor ◽  
Specific Memory ◽  
Lymphocyte Recirculation

scholarly journals Ex Vivo Phenotype and Frequency of Influenza Virus-Specific CD4 Memory T Cells

2004 ◽  
Vol 78 (13) ◽  
pp. 7284-7287 ◽  
Author(s):  
Michaela Lucas ◽  
Cheryl L. Day ◽  
Jessica R. Wyer ◽  
Sharon L. Cunliffe ◽  
Andrew Loughry ◽  
...  
Keyword(s):  
T Cells ◽  
Influenza Virus ◽  
Cd4 T Cells ◽  
Memory T Cells ◽  
Ex Vivo ◽  
Class Ii ◽  
Low Frequencies ◽  
Tetramer Staining ◽  
Specific Memory ◽  
Memory Cd4 T Cells

ABSTRACT Recent advances in class II tetramer staining technology have allowed reliable direct ex vivo visualization of antigen-specific CD4 T cells. In order to define the frequency and phenotype of a prototype response to a nonpersistent pathogen, we have used such techniques to analyze influenza virus-specific memory CD4 T cells directly from blood. These responses are stably detectable ex vivo at low frequencies (range, 0.00012 to 0.0061% of CD4 T cells) and display a distinct “central memory” CD62L+ phenotype.

77-P: Organ Specififity of Cross-Reactive Allogeneic Responses by Viral Specific Memory T-Cells

2010 ◽  
Vol 71 ◽  
pp. S69
Author(s):  
Lloyd D'Orsogna ◽  
Ellen van der Meer-Prins ◽  
Pieter van der Pol ◽  
Marry Franke-van Dijk ◽  
Yvonne Zoet ◽  
...  
Keyword(s):  
T Cells ◽  
Memory T Cells ◽  
Specific Memory

Virus-specific memory T cells are Pgp-1+ and can be selectively activated with phorbol ester and calcium lonophore

1988 ◽  
Vol 113 (2) ◽  
pp. 268-277 ◽  
Author(s):  
Zsuzsanna Tabi ◽  
Felicity Lynch ◽  
Rhodri Ceredig ◽  
Jane E. Allan ◽  
Peter C. Doherty
Keyword(s):  
T Cells ◽  
Phorbol Ester ◽  
Memory T Cells ◽  
Specific Memory

scholarly journals Correlation between Interferon‐γ Secretion and Cytotoxicity, in Virus‐Specific Memory T Cells

2004 ◽  
Vol 190 (9) ◽  
pp. 1692-1696 ◽  
Author(s):  
Helen Horton ◽  
Nina Russell ◽  
Erin Moore ◽  
Ian Frank ◽  
Ruth Baydo ◽  
...  
Keyword(s):  
T Cells ◽  
Memory T Cells ◽  
Interferon Γ ◽  
Specific Memory

High levels of CMV-IE-1-specific memory T cells are associated with less alloimmunity and improved renal allograft function

2009 ◽  
Vol 20 (4) ◽  
pp. 238-242 ◽  
Author(s):  
Peter Nickel ◽  
Gantuja Bold ◽  
Franziska Presber ◽  
Didier Biti ◽  
Nina Babel ◽  
...  
Keyword(s):  
T Cells ◽  
Renal Allograft ◽  
Memory T Cells ◽  
Specific Memory ◽  
Allograft Function

scholarly journals Gut memories do not fade: epigenetic regulation of lasting gut homing receptor expression in CD4+ memory T cells

2017 ◽  
Vol 10 (6) ◽  
pp. 1443-1454 ◽  
Author(s):  
B A Szilagyi ◽  
J Triebus ◽  
C Kressler ◽  
M de Almeida ◽  
S Tierling ◽  
...  
Keyword(s):  
T Cells ◽  
Epigenetic Regulation ◽  
Memory T Cells ◽  
Receptor Expression ◽  
Homing Receptor

Distribution of antigen specific memory T cells in lymph nodes after immunization at peripheral or mucosal sites

1996 ◽  
Vol 74 (3) ◽  
pp. 265-273 ◽  
Author(s):  
ROBERT R PREMIER ◽  
HELEN J JACOBS ◽  
MALCOLM R BRANDON ◽  
ELS NT MEEUSEN
Keyword(s):  
T Cells ◽  
Lymph Nodes ◽  
Memory T Cells ◽  
Specific Memory

scholarly journals CD4 memory T cells survive and proliferate but fail to differentiate in the absence of CD40

2006 ◽  
Vol 203 (4) ◽  
pp. 897-906 ◽  
Author(s):  
Megan MacLeod ◽  
Mark J. Kwakkenbos ◽  
Alison Crawford ◽  
Sheila Brown ◽  
Brigitta Stockinger ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Memory T Cells ◽  
Cell Receptor ◽  
Memory Cells ◽  
Cell Stage ◽  
Effector Cells ◽  
Cell Responses ◽  
Histocompatibility Complex ◽  
Specific Memory

Secondary T cell responses are enhanced because of an expansion in numbers of antigen-specific (memory) cells. Using major histocompatibility complex class II tetramers we have tracked peptide-specific endogenous (non–T cell receptor transgenic) CD4 memory T cells in normal and in costimulation-deficient mice. CD4 memory T cells were detectable after immunization for more than 200 days, although decay was apparent. Memory cells generated in CD40 knockout mice by immunization with peptide-pulsed wild-type dendritic cells survived in the absence of CD40 and proliferated when boosted with peptide (plus adjuvant) in a CD40-independent fashion. However, differentiation of the memory cells into cytokine-producing effector cells did not occur in the absence of CD40. The data indicate that memory cells can be generated without passing through the effector cell stage.

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