Enhanced follicular dendritic cell function in lymph nodes of simian immunodeficiency virus-infected macaques: Consequences for pathogenesis

1997 ◽  
Vol 27 (12) ◽  
pp. 3214-3222 ◽  
Author(s):  
Yvonne J. Rosenberg ◽  
Mark G. Lewis ◽  
Jack J. Greenhouse ◽  
Aurelio Cafaro ◽  
Enrique C. Leon ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Lymph Nodes ◽  
Simian Immunodeficiency Virus ◽  
Cell Function ◽  
Follicular Dendritic Cell ◽  
Dendritic Cell Function ◽  
Immunodeficiency Virus ◽  
Follicular Dendritic

scholarly journals The CTA1-DD adjuvant strongly potentiates follicular dendritic cell function and germinal center formation, which results in improved neonatal immunization

2020 ◽  
Vol 13 (3) ◽  
pp. 545-557
Author(s):  
Sophie Schussek ◽  
Valentina Bernasconi ◽  
Johan Mattsson ◽  
Ulf Alexander Wenzel ◽  
Anneli Strömberg ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Germinal Center ◽  
Cell Function ◽  
Follicular Dendritic Cell ◽  
Dendritic Cell Function ◽  
Follicular Dendritic ◽  
Germinal Center Formation

scholarly journals Repeated Antigen Challenge Modulates Expression of Follicular Dendritic Cell (FDC) Related Molecule in Draining Lymph Nodes.

2001 ◽  
Vol 34 (4) ◽  
pp. 265-273 ◽  
Author(s):  
Yoshiaki Ohmori ◽  
Toshiko Yoshida ◽  
Motonori Okabe ◽  
Kenichi Takaya ◽  
Fumitomo Koizumi ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Lymph Nodes ◽  
Follicular Dendritic Cell ◽  
Antigen Challenge ◽  
Related Molecule ◽  
Follicular Dendritic ◽  
Draining Lymph Nodes

scholarly journals Establishment of Lymphotoxin β Receptor Signaling-Dependent Cell Lines with Follicular Dendritic Cell Phenotypes from Mouse Lymph Nodes

2006 ◽  
Vol 177 (8) ◽  
pp. 5204-5214 ◽  
Author(s):  
Yumiko Nishikawa ◽  
Masaki Hikida ◽  
Masaki Magari ◽  
Naoki Kanayama ◽  
Masaharu Mori ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Lymph Nodes ◽  
Cell Lines ◽  
Follicular Dendritic Cell ◽  
Receptor Signaling ◽  
Dependent Cell ◽  
Follicular Dendritic ◽  
Β Receptor ◽  
Cell Phenotypes

Sarcomatoid tumours of lymph nodes showing follicular dendritic cell differentiation

1991 ◽  
Vol 163 (3) ◽  
pp. 205-216 ◽  
Author(s):  
Kevin Hollowood ◽  
Christopher Pease ◽  
Alasdair M. Mackay ◽  
Christopher D. M. Fletcher
Keyword(s):  
Cell Differentiation ◽  
Dendritic Cell ◽  
Lymph Nodes ◽  
Follicular Dendritic Cell ◽  
Dendritic Cell Differentiation ◽  
Follicular Dendritic

scholarly journals Enhanced Follicular Dendritic Cell-B Cell Interaction in HIV and SIV Infections and its Potential Role in Polyclonal B Cell Activation

1998 ◽  
Vol 6 (1-2) ◽  
pp. 61-70 ◽  
Author(s):  
Yvonne J. Rosenberg ◽  
Mark. G. Lewis ◽  
Marie H. Kosco-Vilbois
Keyword(s):  
Lymph Node ◽  
Dendritic Cell ◽  
B Cell ◽  
Cell Activation ◽  
Follicular Dendritic Cell ◽  
Cell Interaction ◽  
Germinal Centers ◽  
B Cell Activation ◽  
Immunodeficiency Virus ◽  
Follicular Dendritic

Human immunodeficiency virus (HIV) infections have been characterized by both polyclonal Bcell activation and enhanced responsiveness to B-cell growth factors on one hand and the loss of specific antibody (Ab) responses and refractoriness to the normal signals for B-cell activation on the other. Histopathological studies of lymph node from HIV- and simian immunodeficiency virus (SIV)-infected individuals have indicated initial follicular hyperplasia and the appearance of large irregular germinal centers that undergo progressive involution concomitant with follicular dendritic-cell (FDC) disruption. During this process, follicular dendritic-cell -enriched lymph-node-cell cultures exhibit increased ability to induce cluster formation (“in vitrogerminal centers”), lymphocyte proliferation and antibody production compared to uninfected controls. This paper discusses how enhanced FDC-B-cell interaction within SIV-infected germinal centers may result in a reduced ability to select high-affinity B cells and alter the dynamics of antibodyproducing- cell and memory-cell generation resulting in the observed hyperactivity.

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