An Efficient Synthesis of Substituted meta-Halophenols and Their Methyl Ethers: Insight into the Reaction Mechanism

2010 ◽  
Vol 2010 (15) ◽  
pp. 2954-2970 ◽  
Author(s):  
Faiz Ahmed Khan ◽  
Sumit Choudhury
Keyword(s):  
Reaction Mechanism ◽  
Efficient Synthesis ◽  
Insight Into

An atomic-level insight into the basic mechanism responsible for the enhancement of the catalytic oxidation of carbon monoxide on a Cu/CeO2 surface

2017 ◽  
Vol 19 (5) ◽  
pp. 3498-3505 ◽  
Author(s):  
Kenichi Koizumi ◽  
Katsuyuki Nobusada ◽  
Mauro Boero
Keyword(s):  
Carbon Monoxide ◽  
Reaction Mechanism ◽  
Catalytic Oxidation ◽  
Morphological Changes ◽  
Basic Mechanism ◽  
Atomic Level ◽  
Insight Into ◽  
Oxidation Of Carbon Monoxide

Reaction mechanism of CO molecules onto a Cu/CeO2 surface and morphological changes.

The crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase (T1): insight into the reaction mechanism of its thiolase and thioesterase activities

2014 ◽  
Vol 70 (12) ◽  
pp. 3212-3225 ◽  
Author(s):  
Tiila-Riikka Kiema ◽  
Rajesh K. Harijan ◽  
Malgorzata Strozyk ◽  
Toshiyuki Fukao ◽  
Stefan E. H. Alexson ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Reaction Mechanism ◽  
Active Site ◽  
Quaternary Structure ◽  
Fatty Acyl ◽  
Physiological Importance ◽  
Loop Domain ◽  
Solution Studies ◽  
Hydrolysis Of ◽  
Insight Into

Crystal structures of human mitochondrial 3-ketoacyl-CoA thiolase (hT1) in the apo form and in complex with CoA have been determined at 2.0 Å resolution. The structures confirm the tetrameric quaternary structure of this degradative thiolase. The active site is surprisingly similar to the active site of theZoogloea ramigerabiosynthetic tetrameric thiolase (PDB entries 1dm3 and 1m1o) and different from the active site of the peroxisomal dimeric degradative thiolase (PDB entries 1afw and 2iik). A cavity analysis suggests a mode of binding for the fatty-acyl tail in a tunnel lined by the Nβ2–Nα2 loop of the adjacent subunit and the Lα1 helix of the loop domain. Soaking of the apo hT1 crystals with octanoyl-CoA resulted in a crystal structure in complex with CoA owing to the intrinsic acyl-CoA thioesterase activity of hT1. Solution studies confirm that hT1 has low acyl-CoA thioesterase activity for fatty acyl-CoA substrates. The fastest rate is observed for the hydrolysis of butyryl-CoA. It is also shown that T1 has significant biosynthetic thiolase activity, which is predicted to be of physiological importance.

Iodosobenzene-Mediated α-Acyloxylation of 1,3-Dicarbonyl Compounds with Carboxylic Acids and Insight into the Reaction Mechanism

2018 ◽  
Vol 83 (5) ◽  
pp. 2904-2911 ◽  
Author(s):  
Chitturi Bhujanga Rao ◽  
Jingwen Yuan ◽  
Qian Zhang ◽  
Rui Zhang ◽  
Ning Zhang ◽  
...  
Keyword(s):  
Reaction Mechanism ◽  
Carboxylic Acids ◽  
Dicarbonyl Compounds ◽  
Insight Into

New insight into lignin aggregation guiding efficient synthesis and functionalization of a lignin nanosphere with excellent performance

2021 ◽  
Author(s):  
Liheng Chen ◽  
Si-Man Luo ◽  
Cong-Min Huo ◽  
Yun-Feng Shi ◽  
Jun Feng ◽  
...  
Keyword(s):  
Molecular Mechanism ◽  
Efficient Synthesis ◽  
Excellent Performance ◽  
Biomass Valorization ◽  
Insight Into

Understanding the molecular mechanism of lignin nanoparticle (LNP) formation will precisely instruct its functionalization, which is of importance for biomass valorization.

Further theoretical insight into the reaction mechanism of the hepatitis C NS3/NS4A serine protease

2015 ◽  
Vol 619 ◽  
pp. 97-102 ◽  
Author(s):  
José Ángel Martínez-González ◽  
Alex Rodríguez ◽  
María Pilar Puyuelo ◽  
Miguel González ◽  
Rodrigo Martínez
Keyword(s):  
Hepatitis C ◽  
Reaction Mechanism ◽  
Serine Protease ◽  
Theoretical Insight ◽  
Insight Into
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