Activation of ephrinB-EphB receptor signalling in rat spinal cord contributes to maintenance of diabetic neuropathic pain

2016 ◽  
Vol 21 (2) ◽  
pp. 278-288 ◽  
Author(s):  
X.-T. Deng ◽  
M.-Z. Wu ◽  
N. Xu ◽  
P.-C. Ma ◽  
X.-J. Song
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Rat Spinal Cord ◽  
Diabetic Neuropathic Pain ◽  
Receptor Signalling ◽  
Ephb Receptor

Caveolin-1 in Spinal Cord Modulates Type-2 Diabetic Neuropathic Pain Through the Rac1/NOX2/NR2B Signaling Pathway

2019 ◽  
Author(s):  
Jia-Li Chen ◽  
Qi Huang ◽  
Yan-Nan Cao ◽  
Ci-shan Xie ◽  
Yu-jing Shen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Signaling Pathway ◽  
Diabetic Neuropathic Pain ◽  
Caveolin 1 ◽  
Type 2 Diabetic

scholarly journals EGCG Prevents the Loss of Pontine Noradrenergic Neurons Induced by Diabetes: A Role in Diabetic Neuropathic Pain

2012 ◽  
Vol 18 (S5) ◽  
pp. 5-6 ◽  
Author(s):  
Carla Morgado ◽  
João Silva ◽  
André Miranda ◽  
Patrícia Pereira-Terra ◽  
Diogo Raposo ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Diabetic Rats ◽  
Pain Modulation ◽  
Diabetic Patients ◽  
Spontaneous Pain ◽  
Noradrenergic Neurons ◽  
Diabetic Neuropathic Pain ◽  
Descending Pain Modulation ◽  
Pain Responses

Diabetes is a major health problem with an alarming increasing prevalence, and is the most frequent cause of neuropathy worldwide. Neuropathy affects 50–60% of diabetic patients, being a major life-quality impairment for a quarter of these patients. Diabetic neuropathic pain (DNP) is characterized by spontaneous pain, mechanical hyperalgesia and tactile allodynia and is accompanied by functional and neurochemical changes at the peripheral nerves, spinal cord and supraspinal pain control areas. Regarding the effects of diabetic neuropathy in the central somatossensory system, it was shown that streptozotocin (STZ)-diabetic rats present spontaneous hyperactivity and hyperexcitability of spinal nociceptive neurons, which may be subserving the exacerbated pain responses. The spinal functional changes and pain may be due to increased peripheral input(2), changes in spinal nociceptive modulatory mechanisms and altered supraspinal descending pain modulation. Noradrenergic descending pain modulation seems to be impaired since STZ-diabetic rats present decreased numbers of noradrenergic neurons at the A5 and A7 pontine cell groups, along with lower levels of noradrenaline at the spinal cord and higher behavioral responses to pain. This is consistent with the strong noradrenergic projection from A5 and A7 neurons to the spinal dorsal horn and the modulation of nociceptive transmission by local release of noradrenaline. The mechanisms underlying the decrease in noradrenergic neurons in the brainstem during diabetes remain unclear. Our recent findings that diabetes induces oxidative stress damage in neurons from those areas, lead us to hypothesize that it may contribute to their loss. Thereafter, with the present study we aimed to evaluate the effects of Epigallocathechin Gallate (EGCG), a potent antioxidant present in green tea, on spinal noradrenaline levels, on A5 and A7 noradrenergic neurons and on behavioral pain responses of STZ-diabetic rats.

Pannexin 1: A novel participant in neuropathic pain signaling in the rat spinal cord

Pain ◽  
2014 ◽  
Vol 155 (10) ◽  
pp. 2108-2115 ◽  
Author(s):  
David Bravo ◽  
Paula Ibarra ◽  
Jeffri Retamal ◽  
Teresa Pelissier ◽  
Claudio Laurido ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Rat Spinal Cord ◽  
Pannexin 1

F105 IMPAIRED OPIOID RECEPTOR EXPRESSION, COUPLING AND EFFICACY IN SPINAL CORD SENSORY NEURONS OF RATS WITH STREPTOZOTOCIN-INDUCED DIABETIC NEUROPATHIC PAIN

2011 ◽  
Vol 5 (S1) ◽  
pp. 104-104
Author(s):  
M. Shaqura ◽  
B. Khalefa ◽  
M. Shakibaei ◽  
M. Al-Khrasani ◽  
S. Fürst ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Opioid Receptor ◽  
Sensory Neurons ◽  
Receptor Expression ◽  
Diabetic Neuropathic Pain

Neuropathic Pain Modifies Antioxidant Activity in Rat Spinal Cord

2006 ◽  
Vol 31 (5) ◽  
pp. 603-609 ◽  
Author(s):  
Renata P. Guedes ◽  
Lidiane Dal Bosco ◽  
Camila M. Teixeira ◽  
Alex S. R. Araújo ◽  
Susana Llesuy ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Antioxidant Activity ◽  
Neuropathic Pain ◽  
Rat Spinal Cord

Rapamycin ameliorates neuropathic pain by activating autophagy and inhibiting interleukin-1β in the rat spinal cord

2014 ◽  
Vol 34 (6) ◽  
pp. 830-837 ◽  
Author(s):  
Tao Feng ◽  
Qin Yin ◽  
Ze-lin Weng ◽  
Jian-cheng Zhang ◽  
Kun-feng Wang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Interleukin 1Β ◽  
Rat Spinal Cord

scholarly journals Repetitive Treatment with Diluted Bee Venom Attenuates the Induction of Below-Level Neuropathic Pain Behaviors in a Rat Spinal Cord Injury Model

Toxins ◽  
2015 ◽  
Vol 7 (7) ◽  
pp. 2571-2585 ◽  
Author(s):  
Suk-Yun Kang ◽  
Dae-Hyun Roh ◽  
Jung-Wan Choi ◽  
Yeonhee Ryu ◽  
Jang-Hern Lee
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neuropathic Pain ◽  
Bee Venom ◽  
Rat Spinal Cord ◽  
Pain Behaviors ◽  
Spinal Cord Injury Model ◽  
Injury Model ◽  
Cord Injury

Sigma 1 receptor mediated HMGB1 expression in spinal cord is involved in the development of diabetic neuropathic pain

2018 ◽  
Vol 668 ◽  
pp. 164-168 ◽  
Author(s):  
Xiaolei Wang ◽  
Chang Feng ◽  
Yong Qiao ◽  
Xin Zhao
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Diabetic Neuropathic Pain ◽  
Sigma 1 Receptor ◽  
Sigma 1 ◽  
Hmgb1 Expression
Sign in / Sign up

Export Citation Format

Share Document