Application of Single‐use Electrode Based on Nano‐clay and MWCNT for Simultaneous Determination of Acetaminophen, Ascorbic Acid and Acetylsalicylic Acid in Pharmaceutical Dosage

2020 ◽  
Vol 32 (6) ◽  
pp. 1263-1272 ◽  
Author(s):  
Dilek Eskiköy Bayraktepe ◽  
Zehra Yazan
Keyword(s):  
Ascorbic Acid ◽  
Acetylsalicylic Acid ◽  
Simultaneous Determination ◽  
Nano Clay ◽  
Single Use

SIMULTANEOUS DETERMINATION OF ACETAMINOPHEN, ACETYLSALICYLIC ACID AND ASCORBIC ACID IN TABLET FORM USING HPLC

1999 ◽  
Vol 15 (2-3) ◽  
Author(s):  
Cemal Akay ◽  
Bülent Gümüsel ◽  
Tuncer Degim ◽  
Senol Tartılmıs ◽  
S. Cevheroglu
Keyword(s):  
Ascorbic Acid ◽  
Acetylsalicylic Acid ◽  
Simultaneous Determination ◽  
Tablet Form

scholarly journals Simultaneous Determination of Ascorbic Acid and Acetylsalicylic Acid in Pharmaceutical Formulations

2001 ◽  
Vol 84 (1) ◽  
pp. 37-42 ◽  
Author(s):  
M Ines Toral ◽  
Nelson Lara ◽  
Pablo Richter ◽  
Andres Tassara ◽  
A E Tapia ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Standard Deviation ◽  
Acetylsalicylic Acid ◽  
Simultaneous Determination ◽  
Analytical Signal ◽  
Pharmaceutical Formulations ◽  
Zero Crossing ◽  
First Derivative ◽  
Methanolic Hydrochloric Acid

Abstract A direct, simple, and practical first-derivative spectrophotometric method is described for simultaneous determination of ascorbic acid and acetylsalicylic acid. The effects of the solvent, excipients, and spectral variables on the analytical signal were investigated. The drugs were determined simultaneously with a 0.01M methanolic hydrochloric acid solution as the solvent, and the signals were evaluated directly by using the zero-crossing method at 245.0 and 256.0 nm for acetylsalicylic acid and ascorbic acid, respectively. The method allows the simultaneous determinations of acetylsalicylic acid and ascorbic acid in the ranges of 6.6 × 10−6 to 1.5 × 10−4M and 3.4 × 10−6 to 2.0 × 10−4M, respectively, with standard deviation of <2.0%. The proposed method was applied to determinations of these drugs in tablets.

3DGH-Fc based electrochemical sensor for the simultaneous determination of ascorbic acid, dopamine and uric acid

2017 ◽  
Vol 799 ◽  
pp. 459-467 ◽  
Author(s):  
Qing Zhu ◽  
Jing Bao ◽  
Danqun Huo ◽  
Mei Yang ◽  
Huixiang Wu ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Uric Acid ◽  
Electrochemical Sensor ◽  
Simultaneous Determination

scholarly journals Application of Liquid Chromatography to the Simultaneous Determination of Acetylsalicylic Acid, Caffeine, Codeine, Paracetamol, Pyridoxine, and Thiamine in Pharmaceutical Preparations

2001 ◽  
Vol 84 (3) ◽  
pp. 676-683 ◽  
Author(s):  
Natividad Ramos-Martos ◽  
Francisco Aguirre-Gómez ◽  
Antonio Molina-Díaz ◽  
Luis F Capitán-Vallvey
Keyword(s):  
Salicylic Acid ◽  
Acetylsalicylic Acid ◽  
Simultaneous Determination ◽  
Pharmaceutical Preparations ◽  
Reversed Phase ◽  
Liquid Chromatographic Method ◽  
Relative Standard ◽  
Phase Liquid ◽  
Liquid Chromatographic

Abstract This paper describes a rapid reversed-phase liquid chromatographic method, with UV detection, for the simultaneous determination of acetylsalicylic acid, caffeine, codeine, paracetamol, pyridoxine, and thiamine in pharmaceutical preparations. A reversed-phase C18 Nucleosil column is used. The mobile phase consists of 2 successive eluants: water (5 min) and acetonitrile–water (75 + 25, v/v; 9 min), both adjusted to pH 2.1 with phosphoric acid. Before determination acetylsalicylic acid is completely converted to salicylic acid by alkaline hydrolysis. Salicylic acid, caffeine, paracetamol, pyridoxine, and thiamine are all detected at 285 nm, whereas codeine is detected at 240 nm. Calibration curves were linear for salicylic acid, caffeine, paracetamol, and pyridoxine in the range of 50–500 mg/L, and for codeine and thiamine in the range of 50–1000 mg/L. The method was applied to the analysis of 13 fortified commercial pharmaceutical preparations. Recoveries ranged from 92.6 to 105.5%, with relative standard deviations of 1.1–5.8%.

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