Developmental and Hepatic Gene Expression Changes in Chicken Embryos Exposed to p ‐tert‐butylphenyl Diphenyl Phosphate and Isopropylphenyl Phosphate via Egg Injection

2021 ◽  
Author(s):  
Phuoc Tyler Ton‐That Nguyen ◽  
Florence Pagé‐Larivière ◽  
Kim Williams ◽  
Jason O’Brien ◽  
Doug Crump
Keyword(s):  
Gene Expression ◽  
Hepatic Gene Expression ◽  
Chicken Embryos ◽  
Egg Injection ◽  
Diphenyl Phosphate

The Oral Intake of Organic Germanium, Ge-132, Elevates α-Tocopherol Levels in the Plas-ma and Modulates Hepatic Gene Expression Profiles to Promote Immune Activation in Mice

2014 ◽  
Vol 84 (3-4) ◽  
pp. 0183-0195 ◽  
Author(s):  
Takashi Nakamura ◽  
Tomoya Takeda ◽  
Yoshihiko Tokuji
Keyword(s):  
Gene Expression ◽  
Immune Activation ◽  
Expression Profiles ◽  
Water Soluble ◽  
Alpha Tocopherol ◽  
Hepatic Gene Expression ◽  
Tocopherol Concentration ◽  
Altered Expression ◽  
Atp Production ◽  
Transfer Protein

The common water-soluble organic germanium compound poly-trans-[(2-carboxyethyl) germasesquioxane] (Ge-132) exhibits activities related to immune responses and antioxidant induction. In this study, we evaluated the antioxidative effect of dietary Ge-132 in the plasma of mice. Male ICR mice (seven mice per group) received an AIN-76 diet with 0.05 % Ge-132; three groups received the Ge-132-containing diet for 0, 1 or 4 days. The plasma alpha-tocopherol (α-tocopherol) concentration increased from 6.85 to 9.60 μg/ml after 4 days of Ge-132 intake (p < 0.05). We evaluated the changes in hepatic gene expression related to antioxidative activity as well as in the entire expression profile after one day of Ge-132 intake, using DNA microarray technology. We identified 1,220 genes with altered expression levels greater than 1.5-fold (increased or decreased) as a result of Ge-132 intake, and α-tocopherol transfer protein (Ttpa) gene expression was increased 1.62-fold. Immune activation was identified as the category with the most changes (containing 60 Gene Ontology (GO) term biological processes (BPs), 41 genes) via functional clustering analysis of altered gene expression. Ge-132 affected genes in clusters related to ATP production (22 GO term BPs, 21 genes), lipid metabolism (4 GO term BPs, 38 genes) and apoptosis (5 GO term BPs). Many GO term BPs containing these categories were significantly affected by the Ge-132 intake. Oral Ge-132 intake may therefore have increased plasma α-tocopherol levels by up-regulating α-tocopherol transfer protein (Ttpa) gene expression.

scholarly journals Rapid effects of triiodothyronine on hepatic gene expression. Hybridization analysis of tissue-specific triiodothyronine regulation of mRNAS14.

1984 ◽  
Vol 259 (5) ◽  
pp. 2789-2797 ◽  
Author(s):  
D B Jump ◽  
P Narayan ◽  
H Towle ◽  
J H Oppenheimer
Keyword(s):  
Gene Expression ◽  
Hybridization Analysis ◽  
Hepatic Gene Expression ◽  
Tissue Specific

Mo1530 Ligand Dependent Hepatic Gene Expression Profiles of Nuclear Receptors Car and PXR

2012 ◽  
Vol 142 (5) ◽  
pp. S-988
Author(s):  
Satoru Kakizaki ◽  
Hiroki Tojima ◽  
Yuichi Yamazaki ◽  
Daichi Takizawa ◽  
Norio Horiguchi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nuclear Receptors ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Hepatic Gene Expression

scholarly journals Early Life Exposure to Fructose Alters Maternal, Fetal and Neonatal Hepatic Gene Expression and Leads to Sex-Dependent Changes in Lipid Metabolism in Rat Offspring

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0141962 ◽  
Author(s):  
Zoe E. Clayton ◽  
Mark H. Vickers ◽  
Angelica Bernal ◽  
Cassandra Yap ◽  
Deborah M. Sloboda
Keyword(s):  
Gene Expression ◽  
Lipid Metabolism ◽  
Early Life ◽  
Hepatic Gene Expression ◽  
Rat Offspring ◽  
Early Life Exposure

Hepatic gene expression in genetically histamine H4 receptor deficient mice in normal and inflammatory conditions

2007 ◽  
Vol 56 (S1) ◽  
pp. S49-S50 ◽  
Author(s):  
A. K. Fülöp ◽  
D. Ribita ◽  
A. Falus
Keyword(s):  
Gene Expression ◽  
Hepatic Gene Expression ◽  
Histamine H4 Receptor ◽  
Inflammatory Conditions ◽  
H4 Receptor ◽  
Deficient Mice

scholarly journals Effect of supplementation of a mixture of gluconeogenic precursors during the transition period on performance, blood metabolites and insulin concentrations and hepatic gene expression of dairy cows

2021 ◽  
Vol 272 ◽  
pp. 114791
Author(s):  
Ruth M. Orellana Rivas ◽  
Fabian A. Gutierrez-Oviedo ◽  
Gustavo H. Komori ◽  
Vitor V. Beihling ◽  
Thiago N. Marins ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dairy Cows ◽  
Transition Period ◽  
Blood Metabolites ◽  
Hepatic Gene Expression

scholarly journals Multiple microarray platforms utilized for hepatic gene expression profiling of GH transgenic coho salmon with and without ration restriction

2006 ◽  
Vol 37 (2) ◽  
pp. 259-282 ◽  
Author(s):  
M. L Rise ◽  
S. E Douglas ◽  
D. Sakhrani ◽  
J. Williams ◽  
K V. Ewart ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Coho Salmon ◽  
Hepatic Gene Expression
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