LSAMP, a novel candidate tumor suppressor gene in human osteosarcomas, identified by array comparative genomic hybridization

2009 ◽  
Vol 48 (8) ◽  
pp. 679-693 ◽  
Author(s):  
Stine H. Kresse ◽  
Hege O. Ohnstad ◽  
Erik B. Paulsen ◽  
Bodil Bjerkehagen ◽  
Karoly Szuhai ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Comparative Genomic Hybridization ◽  
Array Comparative Genomic Hybridization ◽  
Suppressor Gene ◽  
Comparative Genomic ◽  
Genomic Hybridization ◽  
Candidate Tumor Suppressor ◽  
Candidate Tumor Suppressor Gene

773: Loss of Expression of Candidate Tumor Suppressor Gene ATIP/MTUS1 in Human Transitional Cell Carcinoma of the Bladder

2007 ◽  
Vol 177 (4S) ◽  
pp. 259-259
Author(s):  
Delphine Amsellem-Ouazana ◽  
Clara Nahmias ◽  
Vincent Molinie ◽  
Caroline Elie ◽  
Rosette Lidereau ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Transitional Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tumor Suppressor Gene ◽  
Transitional Cell ◽  
Suppressor Gene ◽  
Candidate Tumor Suppressor ◽  
Candidate Tumor Suppressor Gene ◽  
Carcinoma Of The Bladder ◽  
Human Transitional Cell Carcinoma

scholarly journals NDST4 Is a Novel Candidate Tumor Suppressor Gene at Chromosome 4q26 and Its Genetic Loss Predicts Adverse Prognosis in Colorectal Cancer

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e67040 ◽  
Author(s):  
Sheng-Tai Tzeng ◽  
Ming-Hong Tsai ◽  
Chi-Long Chen ◽  
Jing-Xing Lee ◽  
Tzu-Ming Jao ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Candidate Tumor Suppressor ◽  
Candidate Tumor Suppressor Gene

Identification of the E1A-Regulated Transcription Factor p120E4F as an Interacting Partner of the RASSF1A Candidate Tumor Suppressor Gene

2004 ◽  
Vol 64 (1) ◽  
pp. 102-107 ◽  
Author(s):  
Sarah L. Fenton ◽  
Ashraf Dallol ◽  
Angelo Agathanggelou ◽  
Luke Hesson ◽  
Jalal Ahmed-Choudhury ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Candidate Tumor Suppressor ◽  
Candidate Tumor Suppressor Gene

Integrative Genomic Analysis Identifies NDRG2 as a Candidate Tumor Suppressor Gene Frequently Inactivated in Clinically Aggressive Meningioma

2005 ◽  
Vol 65 (16) ◽  
pp. 7121-7126 ◽  
Author(s):  
Eriks A. Lusis ◽  
Mark A. Watson ◽  
Michael R. Chicoine ◽  
Meghan Lyman ◽  
Peter Roerig ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Genomic Analysis ◽  
Suppressor Gene ◽  
Candidate Tumor Suppressor ◽  
Candidate Tumor Suppressor Gene

scholarly journals DOC-2/hDab2, a candidate tumor suppressor gene involved in the development of gestational trophoblastic diseases

Oncogene ◽  
1998 ◽  
Vol 17 (4) ◽  
pp. 419-424 ◽  
Author(s):  
Vilmos Fulop ◽  
Cristiano V Colitti ◽  
David Genest ◽  
Ross S Berkowitz ◽  
Gary K Yiu ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Candidate Tumor Suppressor ◽  
Candidate Tumor Suppressor Gene ◽  
Trophoblastic Diseases ◽  
Gestational Trophoblastic Diseases

scholarly journals Allelic loss analysis of γ-ray-induced mouse thymic lymphomas: two candidate tumor suppressor gene loci on chromosomes 12 and 16

Oncogene ◽  
1998 ◽  
Vol 16 (21) ◽  
pp. 2747-2754 ◽  
Author(s):  
Yasuo Matsumoto ◽  
Shin-ichi Kosugi ◽  
Toshimitsu Shinbo ◽  
Daizen Chou ◽  
Manabu Ohashi ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Allelic Loss ◽  
Loss Analysis ◽  
Candidate Tumor Suppressor ◽  
Candidate Tumor Suppressor Gene ◽  
Γ Ray

scholarly journals Novel Chromosomal Abnormalities Identified by Comparative Genomic Hybridization in Parathyroid Adenomas1

1998 ◽  
Vol 83 (5) ◽  
pp. 1766-1770 ◽  
Author(s):  
Nallasivam Palanisamy ◽  
Yasuo Imanishi ◽  
Pulivarthi H. Rao ◽  
Hideki Tahara ◽  
R. S. K. Chaganti ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Comparative Genomic Hybridization ◽  
Tumor Suppressor Genes ◽  
Chromosomal Abnormalities ◽  
Suppressor Gene ◽  
Comparative Genomic ◽  
Parathyroid Tumor ◽  
Genomic Hybridization ◽  
Suppressor Genes ◽  
Parathyroid Adenomas

The molecular basis of parathyroid adenomatosis includes defects in the cyclin D1/PRAD1 and MEN1 genes but is, in large part, unknown. To identify new locations of parathyroid oncogenes or tumor suppressor genes, and to further establish the importance of DNA losses described by molecular allelotyping, we performed comparative genomic hybridization (CGH) on a panel of 53 typical sporadic (nonfamilial) parathyroid adenomas. CGH is a new molecular cytogenetic technique in which the entire tumor genome is screened for chromosomal gains and/or losses. Two abnormalities, not previously described, were found recurrently: gain of chromosome 16p (6 of 53 tumors, or 11%) and gain of chromosome 19p (5 of 53, or 9%). Losses were found frequently on 11p (14 of 53, or 26%), as well as 11q (18 of 53, or 34%). Recurrent losses were also seen on chromosomes 1p, 1q, 6q, 9p, 9q, 13q, and 15q, with frequencies ranging from 8–19%. Twenty-four of the 53 adenomas were also extensively analyzed with polymorphic microsatellite markers for allelic losses, either in this study (11 cases) or previously (13 cases). Molecular allelotyping results were highly concordant with CGH results in these tumors (concordance level of 97.5% for all informative markers/chromosome arms examined). In conclusion, CGH has identified the first two known chromosomal gain defects in parathyroid adenomas, suggesting the existence of direct-acting parathyroid oncogenes on chromosomes 16 and 19. CGH has confirmed the locations of putative parathyroid tumor suppressor genes, also defined by molecular allelotyping, on chromosomes 1p, 6q, 9p, 11q, 13q, and 15q. Finally, CGH has provided new evidence favoring the possibility that distinct parathyroid tumor suppressors exist on 1p and 1q, and has raised the possibility of a parathyroid tumor suppressor gene on 11p, distinct from the MEN1 gene on 11q. CGH can identify recurrent genetic abnormalities in hyperparathyroidism, especially chromosomal gains, that other methods do not detect.

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