Selection of Single Nucleotide Polymorphisms for Association Studies in Candidate Genes

2001 ◽  
Vol 21 (S1) ◽  
pp. S614-S619 ◽  
Author(s):  
Emmanuelle Génin
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Candidate Genes ◽  
Association Studies ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Selection Of

Association studies of multiple candidate genes for Parkinson's Disease using single nucleotide polymorphisms

2002 ◽  
Vol 51 (4) ◽  
pp. 534-534 ◽  
Author(s):  
Yoshio Momose ◽  
Miho Murata ◽  
Kazuhiro Kobayashi ◽  
Masaji Tachikawa ◽  
Yuko Nakabayashi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Single Nucleotide Polymorphisms ◽  
Candidate Genes ◽  
Association Studies ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms

2002 ◽  
Vol 51 (1) ◽  
pp. 133-136 ◽  
Author(s):  
Yoshio Momose ◽  
Miho Murata ◽  
Kazuhiro Kobayashi ◽  
Masaji Tachikawa ◽  
Yuko Nakabayashi ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Single Nucleotide Polymorphisms ◽  
Candidate Genes ◽  
Association Studies ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

SELECTION OF TAGGING SINGLE-NUCLEOTIDE POLYMORPHISMS (SNPs) IN IRAK-M GENE FOR ASSOCIATION STUDIES

Shock ◽  
2006 ◽  
Vol 26 (Supplement 1) ◽  
pp. 18
Author(s):  
Paula Tejera ◽  
Nicole Maca-Meyer ◽  
Chaxiraxi Medina ◽  
Jesus Villar
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Association Studies ◽  
Nucleotide Polymorphisms ◽  
M Gene ◽  
Single Nucleotide ◽  
Selection Of

Identification of 142 single nucleotide polymorphisms in 41 candidate genes for rheumatoid arthritis in the Japanese population

2000 ◽  
Vol 106 (3) ◽  
pp. 293-297 ◽  
Author(s):  
Y. Ohnishi ◽  
K. Suematsu ◽  
M. Minami ◽  
T. Seki ◽  
M. Yukioka ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Single Nucleotide Polymorphisms ◽  
Candidate Genes ◽  
Japanese Population ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

scholarly journals Associations of Two Obesity-Related Single-Nucleotide Polymorphisms with Adiponectin in Chinese Children

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Lijun Wu ◽  
Liwang Gao ◽  
Xiaoyuan Zhao ◽  
Meixian Zhang ◽  
Jianxin Wu ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphisms ◽  
Multiple Testing ◽  
Association Studies ◽  
Statistical Significance ◽  
Additive Model ◽  
Recessive Model ◽  
Chinese Children ◽  
Genome Wide Association Studies ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

Purpose. Genome-wide association studies have found two obesity-related single-nucleotide polymorphisms (SNPs), rs17782313 near the melanocortin-4 receptor (MC4R) gene and rs6265 near the brain-derived neurotrophic factor (BDNF) gene, but the associations of both SNPs with other obesity-related traits are not fully described, especially in children. The aim of the present study is to investigate the associations between the SNPs and adiponectin that has a regulatory role in glucose and lipid metabolism. Methods. We examined the associations of the SNPs with adiponectin in Beijing Child and Adolescent Metabolic Syndrome (BCAMS) study. A total of 3503 children participated in the study. Results. The SNP rs6265 was significantly associated with adiponectin under an additive model (P=0.02 and 0.024, resp.) after adjustment for age, gender, and BMI or obesity statuses. The SNP rs17782313 was significantly associated with low adiponectin under a recessive model. No statistical significance was found between the two SNPs and low adiponectin after correction for multiple testing. Conclusion. We demonstrate for the first time that the SNP rs17782313 near MC4R and the SNP rs6265 near BDNF are associated with adiponectin in Chinese children. These novel findings provide important evidence that adiponectin possibly mediates MC4R and BDNF involved in obesity.

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