Unidentified Genetic Variants Influence Pancreatic Cancer Risk: An Analysis of Polygenic Susceptibility in the PanScan Study

2012 ◽  
Vol 36 (5) ◽  
pp. 517-524 ◽  
Author(s):  
Brandon L. Pierce ◽  
Lin Tong ◽  
Peter Kraft ◽  
Habibul Ahsan
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Risk ◽  
Genetic Variants ◽  
Pancreatic Cancer Risk

Identification of genetic variants in m6A modification genes associated with pancreatic cancer risk in the Chinese population

2021 ◽  
Vol 95 (3) ◽  
pp. 1117-1128
Author(s):  
Pingting Ying ◽  
Yao Li ◽  
Nan Yang ◽  
Xiaoyang Wang ◽  
Haoxue Wang ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Risk ◽  
Genetic Variants ◽  
Chinese Population ◽  
Pancreatic Cancer Risk

scholarly journals Three novel genetic variants in NRF2 signaling pathway genes are associated with pancreatic cancer risk

2019 ◽  
Vol 110 (6) ◽  
pp. 2022-2032
Author(s):  
Wenjun Yang ◽  
Hongliang Liu ◽  
Bensong Duan ◽  
Xinyuan Xu ◽  
Dennis Carmody ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Risk ◽  
Signaling Pathway ◽  
Genetic Variants ◽  
Pancreatic Cancer Risk ◽  
Nrf2 Signaling Pathway

scholarly journals Genetic Variants of p21 and p27 and Pancreatic Cancer Risk in Non-Hispanic Whites

Pancreas ◽  
2010 ◽  
Vol 39 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Jinyun Chen ◽  
Christopher I. Amos ◽  
Kelly W. Merriman ◽  
Qingyi Wei ◽  
Subrata Sen ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Risk ◽  
Genetic Variants ◽  
Pancreatic Cancer Risk

scholarly journals Association of genetic variants affecting microRNAs and pancreatic cancer risk

Pancreatology ◽  
2021 ◽  
Vol 21 ◽  
pp. S60-S62
Author(s):  
Y. Lu ◽  
C. Corradi ◽  
M. Gentiluomo ◽  
G.E. Theodoropoulos ◽  
S. Roth ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Risk ◽  
Genetic Variants ◽  
Pancreatic Cancer Risk

scholarly journals Associations between genetic variants of KIF5B , FMN1 , and MGAT3 in the cadherin pathway and pancreatic cancer risk

2020 ◽  
Vol 9 (24) ◽  
pp. 9620-9631
Author(s):  
Lingling Zhao ◽  
Hongliang Liu ◽  
Sheng Luo ◽  
Patricia G. Moorman ◽  
Kyle M. Walsh ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Risk ◽  
Genetic Variants ◽  
Pancreatic Cancer Risk

Genetic variants in taste-related genes and risk of pancreatic cancer

Mutagenesis ◽  
2019 ◽  
Vol 34 (5-6) ◽  
pp. 391-394 ◽  
Author(s):  
Manuel Gentiluomo ◽  
Ye Lu ◽  
Federico Canzian ◽  
Daniele Campa
Keyword(s):  
Pancreatic Cancer ◽  
Genetic Variability ◽  
Cancer Risk ◽  
Genetic Variants ◽  
Regulatory Elements ◽  
Taste Receptors ◽  
Data Set ◽  
Pancreatic Cancer Risk ◽  
Validation Phase ◽  
The Impact

Abstract Pancreatic ductal adenocarcinoma is an aggressive and relatively rare cancer with a dismal 5-year survival rate and a clear genetic background. Genetic variants in taste receptors and taste-related genes have been associated with a variety of human traits and phenotypes among which several cancer types and pancreatic cancer risk factors. In this study, we analysed 2854 single-nucleotide polymorphisms in 50 taste-related genes, including 37 taste receptors. To cover all the genetic variability of the selected genes and to include also regulatory elements, we added 5000 nucleotides to both ends of each gene. We used a two-phase approach, with the PanScan data set (3314 cases and 3431 controls) as the discovery phase and PanC4 (3893 cases and 3632 controls) as validation phase, for a total of 7207 cases and 7063 controls. The datasets were downloaded from the NCBI database of genotypes and phenotypes (dbGaP). We observed that the taste 1 receptor member 2 (TAS1R2)-rs11261087 variant was associated with pancreatic cancer risk in both phases independently, with a consistent association of the T allele with decreased risk of developing the disease [phase 1 odds ratio (OR) = 0.89, 95% confidence interval (CI) 0.80–0.98; phase 2 OR = 0.91, 95% CI 0.83–0.99; all subjects together OR = 0.90, 95% CI 0.84–0.96, P = 0.002]. However, neither the association observed in the validation phase nor those observed in the joint analysis were statistically significant considering multiple testing. Functional studies are warranted to better understand the impact of the genetic variability of TAS1R2 on PDAC risk.

scholarly journals Genetic variants in carcinogen-metabolizing enzymes, cigarette smoking and pancreatic cancer risk

2012 ◽  
Vol 33 (4) ◽  
pp. 818-827 ◽  
Author(s):  
J.-H. Jang ◽  
M. Cotterchio ◽  
A. Borgida ◽  
S. Gallinger ◽  
S. P. Cleary
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Risk ◽  
Cigarette Smoking ◽  
Genetic Variants ◽  
Metabolizing Enzymes ◽  
Pancreatic Cancer Risk
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