Astroglial cell subtypes in the cerebella of normal adults, elderly adults, and patients with Alzheimer's disease: A histological and immunohistochemical comparison

Glia ◽  
2014 ◽  
Vol 63 (2) ◽  
pp. 287-312 ◽  
Author(s):  
María-Isabel Álvarez ◽  
Luís Rivas ◽  
César Lacruz ◽  
Adolfo Toledano
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Elderly Adults ◽  
Astroglial Cell ◽  
Normal Adults

scholarly journals White matter integrity is associated with cerebrospinal fluid markers of Alzheimer's disease in normal adults

2014 ◽  
Vol 35 (10) ◽  
pp. 2263-2271 ◽  
Author(s):  
Brian T. Gold ◽  
Zude Zhu ◽  
Christopher A. Brown ◽  
Anders H. Andersen ◽  
Mary Jo LaDu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
White Matter ◽  
White Matter Integrity ◽  
Normal Adults

Combination of MRI Hippocampal Volumetry and Arterial Spin Labeling MR Perfusion at 3-Tesla Improves the Efficacy in Discriminating Alzheimer's Disease from Cognitively Normal Elderly Adults

2014 ◽  
Vol 41 (3) ◽  
pp. 749-758 ◽  
Author(s):  
Henry Ka-Fung Mak ◽  
Wenshu Qian ◽  
Kwok Sing Ng ◽  
Queenie Chan ◽  
You-Qiang Song ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
3 Tesla ◽  
Elderly Adults ◽  
Mr Perfusion ◽  
Cognitively Normal

White Matter Lesions or Alzheimer's Disease: Which Contributes More to Overactive Bladder and Incontinence in Elderly Adults with Dementia?

2012 ◽  
Vol 60 (12) ◽  
pp. 2370-2371 ◽  
Author(s):  
Osamu Takahashi ◽  
Ryuji Sakakibara ◽  
Jalesh Panicker ◽  
Clare J. Fowler ◽  
Fuyuki Tateno ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Overactive Bladder ◽  
White Matter Lesions ◽  
Elderly Adults

Multiple Findings in Elderly Adults with Confirmed Alzheimer's Disease

2012 ◽  
Vol 60 (11) ◽  
pp. 2169-2170
Author(s):  
Hiroyasu Akatsu ◽  
Norihiro Ogawa ◽  
Takeshi Kanesaka ◽  
Chie Taniguchi ◽  
Maya Mimuro ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Elderly Adults

scholarly journals A Concept Analysis: Caregivers’ burden of Elderly Adults with Alzheimer’s Disease

2021 ◽  
Vol 17 (02) ◽  
pp. 155-159
Author(s):  
Onuma Kaewkerd ◽  
Jirawan Silaudom ◽  
Benjayamas Benjayamas ◽  
Benjayamas Benjayamas ◽  
Vasinbhath Piyapongsakul ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Concept Analysis ◽  
Elderly Adults

scholarly journals Test–retest characteristic of [18F]MK-6240 quantitative outcomes in cognitively normal adults and subjects with Alzheimer’s disease

2019 ◽  
Vol 40 (11) ◽  
pp. 2179-2187 ◽  
Author(s):  
Cristian Salinas ◽  
Talakad G Lohith ◽  
Ajay Purohit ◽  
Arie Struyk ◽  
Cyrille Sur ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Parenchyma ◽  
Binding Potential ◽  
Cognitively Normal ◽  
Future Studies ◽  
Arterial Blood ◽  
Quantitative Metrics ◽  
The Brain ◽  
Normal Adults

[18F]MK-6240 is a selective, high-affinity PET radiotracer for imaging neurofibrillary tangles (NFT) in Alzheimer’s disease (AD). Herein, we report test–retest (T–RT) reproducibility of [18F]MK-6240 in AD and healthy volunteers (HV). Twelve subjects with AD and three cognitively normal HV were enrolled in the study and dynamically scanned for 150 min with [18F]MK-6240 under a T–RT protocol. Two radioactivity doses were investigated: 165 ± 3 MBq (n = 6) and 300 ± 40 MBq (n = 9). Serial arterial blood samples were taken for each scan to obtain metabolite-corrected input functions. Following intravenous administration of [18F]MK-6240, the tracer rapidly partitioned into the brain and its heterogenous distribution pattern was consistent with known NFT pathology in AD. In contrast, uptake in HV was low and uniform across the brain parenchyma. Across all subjects, average T–RT variabilities in NFT-rich regions were ∼21%, ∼14% and ∼6% for various quantitative metrics: total distribution volume (VT), binding potential (BPND), and standardized uptake ratio (SUVR90–120), respectively. No significant differences in SUVR T–RT variability were observed between the high and low injected radioactivity groups (5.6% and 6.1%, respectively). This work suggests [18F]MK-6240 has adequate SUVR T–RT characteristics supporting the use of this outcome in future studies.

P2-216: Pulsatile arterial spin labeling in differentiating Alzheimer's disease and cognitively normal elderly adults in a Chinese cohort

2012 ◽  
Vol 8 (4S_Part_9) ◽  
pp. P332-P334
Author(s):  
Henry Ka Fung Mak ◽  
Queenie Chan ◽  
Zhipeng Zhang ◽  
Deqiang Qiu ◽  
Linda Zhang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Elderly Adults ◽  
Cognitively Normal ◽  
Chinese Cohort
Sign in / Sign up

Export Citation Format

Share Document