Magnetic resonance imaging‐based radiogenomics analysis for predicting prognosis and gene expression profile in advanced nasopharyngeal carcinoma

Head & Neck ◽  
2021 ◽  
Author(s):  
Yan Gao ◽  
Yitao Mao ◽  
Shanhong Lu ◽  
Lei Tan ◽  
Guo Li ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Gene Expression ◽  
Magnetic Resonance ◽  
Nasopharyngeal Carcinoma ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Resonance Imaging

scholarly journals Early intra-treatment diffusion weighted magnetic resonance imaging in patients with recurrent nasopharyngeal carcinoma treated with nivolumab

2020 ◽  
Vol 6 (3) ◽  
pp. 568
Author(s):  
Tiffany Y. So ◽  
Qi-Yong Ai ◽  
Brigette B.Y. Ma ◽  
Ann D. King
Keyword(s):  
Magnetic Resonance Imaging ◽  
Overall Survival ◽  
Magnetic Resonance ◽  
Nasopharyngeal Carcinoma ◽  
Progression Free Survival ◽  
Tumour Volume ◽  
Resonance Imaging ◽  
Free Survival ◽  
Diffusion Weighted ◽  
Weighted Magnetic Resonance Imaging

<p class="abstract">Immune check point inhibitors have demonstrated promising efficacy in patients with recurrent or metastatic nasopharyngeal carcinoma (NPC) in phase I and phase II trials. Early identification of treatment response is important in these patients. This report aimed to document the early intratreatment diffusion weighted magnetic resonance imaging (DW-MRI) findings in NPC patients following treatment with the programmed cell death-1 inhibitor, nivolumab. Two consecutive patients with histologically confirmed recurrent undifferentiated NPC treated with nivolumab were prospectively recruited. Nivolumab was administered at a dosage of 3 mg/kg intravenously every 2 weeks. Patients underwent magnetic resonance imaging examinations at baseline, and at 3 and 5 weeks after commencement of treatment. Intratreatment changes in tumour volume and apparent diffusion coefficient (ADC<sub>mean</sub>)were calculated. The endpoints were objective response by response evaluation criteria in solid tumors and survival. In patient 1, an intratreatment ADC increase at 5 weeks corresponded with anatomical tumour volume reduction and a better long-term survival outcome (progression free survival 1.3 years, overall survival 2.9 years). In patient 2, an intratreatment ADC decrease at 5 weeks corresponded to progressive disease and worse outcome (progression free survival 0.0 years, overall survival 0.9 years). Intratreatment ADC changes at 3 weeks were not associated with response outcome. These cases suggest that intratreatment changes in ADC at 5 weeks may potentially predict tumour response in patients treated with nivolumab. Dedicated studies are needed to clarify these findings and fully characterise patterns of treatment related ADC change.</p>

Diagnostic Accuracy of Sonography Versus Magnetic Resonance Imaging for Primary Nasopharyngeal Carcinoma

2014 ◽  
Vol 33 (5) ◽  
pp. 827-834 ◽  
Author(s):  
Yong Gao ◽  
Shang-Yong Zhu ◽  
Yi Dai ◽  
Bing-Feng Lu ◽  
Lu Lu
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Nasopharyngeal Carcinoma ◽  
Diagnostic Accuracy ◽  
Resonance Imaging

scholarly journals Staging and follow-up of nasopharyngeal carcinoma: Magnetic resonance imaging versus computerized tomography

1995 ◽  
Vol 32 (3) ◽  
pp. 795-800 ◽  
Author(s):  
Patrizia Olmi ◽  
Carlo Fallai ◽  
Stefano Colagrande ◽  
Gianfranco Giannardi
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Nasopharyngeal Carcinoma ◽  
Computerized Tomography ◽  
Resonance Imaging
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