scholarly journals Magnetic Resonance Imaging–Detected Intracranial Extension in the T4 Classification Nasopharyngeal Carcinoma with Intensity-Modulated Radiotherapy

2017 ◽  
Vol 49 (2) ◽  
pp. 518-525 ◽  
Author(s):  
Caineng Cao ◽  
Jingwei Luo ◽  
Li Gao ◽  
Junlin Yi ◽  
Xiaodong Huang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Nasopharyngeal Carcinoma ◽  
Intensity Modulated Radiotherapy ◽  
Intracranial Extension ◽  
Resonance Imaging ◽  
Intensity Modulated

scholarly journals Utility of Magnetic Resonance Imaging in determining treatment response and local recurrence in Nasopharyngeal Carcinoma treated curatively

2019 ◽  
Author(s):  
Katherine Meng ◽  
Jeremy Tey ◽  
Francis Ho ◽  
Hira Asim ◽  
Timothy Cheo
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Nasopharyngeal Carcinoma ◽  
Local Recurrence ◽  
Residual Disease ◽  
Multivariable Analysis ◽  
Intensity Modulated Radiotherapy ◽  
Optimal Timing ◽  
Resonance Imaging ◽  
Curative Intent

Abstract Background: To determine the optimal timing of the first Magnetic Resonance Imaging (MRI) scan after curative-intent radiotherapy (RT) for nasopharyngeal carcinoma (NPC), and evaluate the role of MRI in surveillance for locoregional recurrence (LRR). Methods: Patients with non-metastatic NPC treated radically with at least one post-treatment MRI (ptMRI) were included for analysis. ptMRI reports were retrospectively reviewed and categorised as complete response (CR), partial response/residual disease (PR) or indeterminate (ID). Patients with LRR were assessed to determine if initial detection was by MRI or clinical means. Univariable and multivariable Cox proportional hazard regression analysis were performed to identify independent factors associated with CR on ptMRIs. Results: Between 2013 and 2017, 262 eligible patients were analysed, all treated with Intensity Modulated Radiotherapy (IMRT). Median time from end of RT to the first ptMRI was 93 days (range 32-346). Of the first ptMRIs, 88 (33.2%) were CR, 133 (50.2%) ID, and 44 (16.6%) PR. A second ptMRI was done for 104 (78.2%) of 133 patients with ID status. In this group, 77 (57.9%) of the subsequent MRI were determined to be CR, 21(15.8%) remained ID and 6 (4.5%) PR. T1 tumour stage and AJCC stage I were associated with increased CR rates on first ptMRI on multivariable analysis. ID status was more likely at 75-105 days (3 months +/- 15 days) vs 106-135 days (4 months +/- 15 days) post RT (OR 2.13, 95% CI 1.16-4.12, p=0.024). LRR developed in 27 (10.1%) patients; 20 (74.1%) was initially detected through MRI, 3 (11.1%) by nasoendoscopy and 2 (7.4%) by PET-CT. Conclusion: MRI is useful for detecting local recurrence or persistent disease after curative-intent treatment. Most patients will need more than one ptMRI to arrive at a definitive status. The rate of ID ptMRI may be reduced by delaying the first scan to around 4 months post RT.

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