Novel roles of galectin-1 in hepatocellular carcinoma cell adhesion, polarization, and in vivo tumor growth

Hepatology ◽  
2011 ◽  
Vol 53 (6) ◽  
pp. 2097-2106 ◽  
Author(s):  
María V. Espelt ◽  
Diego O. Croci ◽  
María L. Bacigalupo ◽  
Pablo Carabias ◽  
Malena Manzi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Adhesion ◽  
Tumor Growth ◽  
Carcinoma Cell ◽  
Hepatocellular Carcinoma Cell

scholarly journals LncRNA-SNHG6 promotes the progression of hepatocellular carcinoma by targeting miR-6509-5p and HIF1A

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xiaoxi Fan ◽  
Zhongwei Zhao ◽  
Jingjing Song ◽  
Dengke Zhang ◽  
Fazong Wu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Growth ◽  
Bioinformatics Analysis ◽  
Carcinoma Cell ◽  
Noncoding Rnas ◽  
Migration And Invasion ◽  
Carcinoma Cell Lines ◽  
Huh7 Cells ◽  
Hepatocellular Carcinoma Cell

Abstract Background Accumulating evidences have been reported that long noncoding RNAs play crucial roles in the progression of hepatocellular carcinoma (HCC). SnoRNA host gene 6 (SNHG6) is believed to be involved in several human cancers, but the specific molecular mechanism of SNHG6 in HCC is not well studied. Methods In this study, we experimentally down-regulated the SNHG6 in two hepatocellular carcinoma cell lines in vitro, and then measured the proliferation, migration and invasion abilities and the apoptotic levels. Also, we performed the xenograft assay to investigate the function of SNHG6 during the tumor growth in vivo. Results We found SNHG6 was highly expressed in HCC tissues. Next, using Hep3B and Huh7 cells, we confirmed knockdown of SNHG6 reduced the proliferation, migration and invasion abilities in vitro. Also, by bioinformatics analysis, further molecular and cellular experiments, we found miR-6509-5p bound to SNHG6 directly, and the expression level of HIF1A was regulated through SNHG6/miR-6509-5p axis. Finally, we found that down-regulation of SNHG6 dramatically reduced the tumor growth ability of Huh7 cells in vivo. Conclusions We concluded that SNHG6/miR-6509-5p/HIF1A axis functioned in the progression of hepatocellular carcinoma, and could be the promising therapeutic targets during the development of hepatocellular carcinoma drugs.

Su1005 Type XVIII Collagen Promotes Hepatocellular Carcinoma Cell Adhesion

2013 ◽  
Vol 144 (5) ◽  
pp. S-992
Author(s):  
Trey Forehand ◽  
Priyanka Thakur ◽  
Michael Duncan
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Adhesion ◽  
Carcinoma Cell ◽  
Hepatocellular Carcinoma Cell

scholarly journals Immediate early response protein 2 regulates hepatocellular carcinoma cell adhesion and motility via integrin β1-mediated signaling pathway

2016 ◽  
Vol 37 (1) ◽  
pp. 259-272 ◽  
Author(s):  
Zhengxin Xu ◽  
Lei Zhu ◽  
Wenjuan Wu ◽  
Yuexia Liao ◽  
Weicheng Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Adhesion ◽  
Signaling Pathway ◽  
Carcinoma Cell ◽  
Early Response ◽  
Immediate Early ◽  
Integrin Β1 ◽  
Hepatocellular Carcinoma Cell

scholarly journals Chloroquine inhibits hepatocellular carcinoma cell growth in vitro and in vivo

2015 ◽  
Vol 35 (1) ◽  
pp. 43-49 ◽  
Author(s):  
TAO HU ◽  
PEI LI ◽  
ZHONGGUANG LUO ◽  
XIAOYU CHEN ◽  
JINGYANG ZHANG ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Growth ◽  
Carcinoma Cell ◽  
Hepatocellular Carcinoma Cell

scholarly journals Activation of AMP-activated protein kinase attenuates hepatocellular carcinoma cell adhesion stimulated by adipokine resistin

BMC Cancer ◽  
2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Chen-Chieh Yang ◽  
Shun-Fu Chang ◽  
Jian-Kang Chao ◽  
Yi-Liang Lai ◽  
Wei-En Chang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Adhesion ◽  
Protein Kinase ◽  
Carcinoma Cell ◽  
Hepatocellular Carcinoma Cell ◽  
Amp Activated Protein Kinase
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