scholarly journals The Impact of Direct‐acting Antiviral Therapy on End Stage Liver Disease Among Individuals with Chronic Hepatitis C and Substance Use Disorders

Hepatology ◽  
2021 ◽  
Author(s):  
Haesuk Park ◽  
Xinyi Jiang ◽  
Hyun Jin Song ◽  
Vincent Lo Re ◽  
Lindsey M. Childs‐Kean ◽  
...  
Keyword(s):  
Substance Use ◽  
Chronic Hepatitis ◽  
Liver Disease ◽  
Hepatitis C ◽  
Substance Use Disorders ◽  
Direct Acting Antiviral ◽  
End Stage Liver Disease ◽  
Direct Acting ◽  
End Stage ◽  
The Impact

scholarly journals Virological Factors Associated with Failure to the Latest Generation of Direct Acting Agents (DAA) and Re-Treatment Strategy: A Narrative Review

Viruses ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 432
Author(s):  
Lorenzo Onorato ◽  
Mariantonietta Pisaturo ◽  
Mario Starace ◽  
Carmine Minichini ◽  
Alessandra Di Fraia ◽  
...  
Keyword(s):  
Liver Disease ◽  
Hepatitis C ◽  
Antiviral Agents ◽  
Clinical Problem ◽  
Narrative Review ◽  
Factors Associated ◽  
Direct Acting Antiviral ◽  
Direct Acting ◽  
The Impact ◽  
Direct Acting Antiviral Agents

The availability of all oral direct acting antiviral agents (DAAs) has revolutionized the management of HCV infections in recent years, allowing to achieve a sustained virological response (SVR) in more than 95% of cases, irrespective of hepatitis C Virus (HCV) genotype or staging of liver disease. Although rare, the failure to the latest-generation regimens (grazoprevir/elbasvir, sofosbuvir/velpatasvir, pibrentasvir/glecaprevir) represents a serious clinical problem, since the data available in the literature on the virological characteristics and management of these patients are few. The aim of the present narrative review was to provide an overview of the impact of baseline RASs in patients treated with the latest-generation DAAs and to analyze the efficacy of the available retreatment strategies in those who have failed these regimens.

Long-Term Course of Chronic Hepatitis C in Children: From Viral Clearance to End-Stage Liver Disease

2008 ◽  
Vol 134 (7) ◽  
pp. 1900-1907 ◽  
Author(s):  
Flavia Bortolotti ◽  
Gabriella Verucchi ◽  
Calogero Cammà ◽  
Giuseppe Cabibbo ◽  
Lucia Zancan ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Liver Disease ◽  
Hepatitis C ◽  
Chronic Hepatitis C ◽  
Viral Clearance ◽  
End Stage Liver Disease ◽  
End Stage
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