Nuclear αvβ3 integrin expression, post translational modifications and regulation in hematological malignancies

2021 ◽  
Author(s):  
Avivit Weisz ◽  
Uri Abadi ◽  
Lisa Mausbach ◽  
David Gurwitz ◽  
Martin Ellis ◽  
...  
Keyword(s):  
Hematological Malignancies ◽  
Αvβ3 Integrin ◽  
Integrin Expression ◽  
Post Translational Modifications

scholarly journals Absence of the αvβ3 Integrin Dictates the Time-Course of Angiogenesis in the Hypoxic Central Nervous System: Accelerated Endothelial Proliferation Correlates with Compensatory Increases in α5β1 Integrin Expression

2010 ◽  
Vol 30 (5) ◽  
pp. 1031-1043 ◽  
Author(s):  
Longxuan Li ◽  
Jennifer V Welser ◽  
Richard Milner
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Time Course ◽  
Αvβ3 Integrin ◽  
Integrin Expression ◽  
Brain Endothelial Cells ◽  
Endothelial Proliferation ◽  
Β3 Integrin ◽  
Α5β1 Integrin

Cerebral angiogenesis is an important adaptive response to hypoxia. As the αvβ3 integrin is induced on angiogenic vessels in the ischemic central nervous system (CNS), and the suggested angiogenic role for this integrin in other systems, it is important to determine whether the αvβ3 integrin is an important mediator of cerebral angiogenesis. αvβ3 integrin expression was examined in a model of cerebral hypoxia, in which mice were subject to hypoxia (8% O2) for 0, 4, 7, or 14 days. Immunofluorescence and western blot analysis revealed that in the hypoxic CNS, αvβ3 integrin was strongly induced on angiogenic brain endothelial cells (BEC), along with its ligand vitronectin. In the hypoxia model, β3 integrin-null mice showed no obvious defect in cerebral angiogenesis. However, early in the angiogenic process, BEC in these mice showed an increased mitotic index that correlated closely with increased α5 integrin expression. In vitro experiments confirmed α5 integrin upregulation on β3 integrin-null BEC, which also correlated with increased BEC proliferation on fibronectin. These studies confirm hypoxic induction of αvβ3 integrin on angiogenic vessels, but suggest distinct roles for the BEC integrins αvβ3 and α5β1 in cerebral angiogenesis, with αvβ3 having a nonessential role, and α5β1 promoting BEC proliferation.

Nitric Oxide Induces Angiogenesis and Upregulates αvβ3 Integrin Expression on Endothelial Cells

2000 ◽  
Vol 60 (3) ◽  
pp. 269-280 ◽  
Author(s):  
Paul C. Lee ◽  
Melina R. Kibbe ◽  
Matthew J. Schuchert ◽  
Donna B. Stolz ◽  
Simon C. Watkins ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cells ◽  
Αvβ3 Integrin ◽  
Integrin Expression

Leukaemia inhibitory factor increases αvβ3 integrin expression in cultured mouse blastocysts

2020 ◽  
pp. NULL
Author(s):  
Ali Hosseini ◽  
Nassim Ghorbanmehr ◽  
Mojtaba Rezazadeh Valojerdi ◽  
Mehrdad Bakhtiyari ◽  
Bahar Movaghar
Keyword(s):  
Inhibitory Factor ◽  
Leukaemia Inhibitory Factor ◽  
Αvβ3 Integrin ◽  
Integrin Expression

ChemInform Abstract: Ligands for Mapping αvβ3-Integrin Expression in vivo

ChemInform ◽  
2009 ◽  
Vol 40 (47) ◽  
Author(s):  
Margret Schottelius ◽  
Burkhardt Laufer ◽  
Horst Kessler ◽  
Hans-Juergen Wester
Keyword(s):  
Αvβ3 Integrin ◽  
Integrin Expression

Non-invasive determination of the αvβ3 integrin expression using [18F]galacto-RGD and pet

2001 ◽  
Vol 44 (S1) ◽  
pp. S96-S98 ◽  
Author(s):  
R. Haubner ◽  
W. A. Weber ◽  
H. J. Wester ◽  
S. I. Ziegler ◽  
E. Vabuliene ◽  
...  
Keyword(s):  
Αvβ3 Integrin ◽  
Integrin Expression ◽  
Non Invasive

Stromal cell-derived factor-1 increase αvβ3 integrin expression and invasion in human chondrosarcoma cells

2009 ◽  
Vol 218 (2) ◽  
pp. 334-342 ◽  
Author(s):  
Tzu-Hsiu Lai ◽  
Yi-Chin Fong ◽  
Wen-Mei Fu ◽  
Rong-Sen Yang ◽  
Chih-Hsin Tang
Keyword(s):  
Stromal Cell ◽  
Αvβ3 Integrin ◽  
Integrin Expression ◽  
Human Chondrosarcoma ◽  
Stromal Cell Derived Factor

scholarly journals 18F-labeled mini-PEG spacered RGD dimer (18F-FPRGD2): synthesis and microPET imaging of αvβ3 integrin expression

2007 ◽  
Vol 34 (11) ◽  
pp. 1823-1831 ◽  
Author(s):  
Zhanhong Wu ◽  
Zi-Bo Li ◽  
Weibo Cai ◽  
Lina He ◽  
Frederick T. Chin ◽  
...  
Keyword(s):  
Αvβ3 Integrin ◽  
Integrin Expression ◽  
Micropet Imaging
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