scholarly journals Leukocyte adhesion molecules in animal models of inflammatory bowel disease

2008 ◽  
Vol 14 (12) ◽  
pp. 1715-1735 ◽  
Author(s):  
Jesús Rivera-Nieves ◽  
Gezahegn Gorfu ◽  
Klaus Ley
Keyword(s):  
Inflammatory Bowel Disease ◽  
Animal Models ◽  
Adhesion Molecules ◽  
Bowel Disease ◽  
Leukocyte Adhesion ◽  
Inflammatory Bowel ◽  
Leukocyte Adhesion Molecules

Expression of leukocyte adhesion molecules by mucosal mononuclear phagocytes in inflammatory bowel disease

1991 ◽  
Vol 100 (1) ◽  
pp. 150-159 ◽  
Author(s):  
Giuseppe Malizia ◽  
Antonino Calabrese ◽  
Mario Cottone ◽  
Massimo Raimondo ◽  
Ludwik K. Trejdosiewicz ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Adhesion Molecules ◽  
Bowel Disease ◽  
Leukocyte Adhesion ◽  
Mononuclear Phagocytes ◽  
Inflammatory Bowel ◽  
Leukocyte Adhesion Molecules

scholarly journals Altered expression of cell adhesion molecules in uninvolved gut in inflammatory bowel disease

2008 ◽  
Vol 94 (2) ◽  
pp. 341-347 ◽  
Author(s):  
G. M. SCHUERMANN ◽  
A. E. ABER-BISHOP ◽  
P. FACER ◽  
J. C. LEE ◽  
D. S. RAMPTON ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Bowel Disease ◽  
Cell Adhesion Molecules ◽  
Altered Expression ◽  
Inflammatory Bowel

Deficient iNOS in inflammatory bowel disease intestinal microvascular endothelial cells results in increased leukocyte adhesion

2000 ◽  
Vol 29 (9) ◽  
pp. 881-888 ◽  
Author(s):  
David G Binion ◽  
Parvaneh Rafiee ◽  
Kalathur S Ramanujam ◽  
Sidong Fu ◽  
Pamela J Fisher ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Endothelial Cells ◽  
Bowel Disease ◽  
Leukocyte Adhesion ◽  
Microvascular Endothelial Cells ◽  
Inflammatory Bowel ◽  
Microvascular Endothelial

Physiological Basis for Novel Drug Therapies Used to Treat the Inflammatory Bowel Diseases I. Immunology and therapeutic potential of antiadhesion molecule therapy in inflammatory bowel disease

2005 ◽  
Vol 288 (2) ◽  
pp. G169-G174 ◽  
Author(s):  
Gert Van Assche ◽  
Paul Rutgeerts
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Adhesion Molecules ◽  
Bowel Disease ◽  
Intestinal Inflammation ◽  
Therapeutic Potential ◽  
Physiological Basis ◽  
Inflammatory Bowel

Adhesion molecules regulate the influx of leukocytes in normal and inflamed gut. They are also involved in local lymphocyte stimulation and antigen presentation within the intestinal mucosa. In intestinal inflammation, many adhesion molecules are upregulated, but α4-integrins most likely hold a key position in directing leukocytes into the inflamed bowel wall. Therapeutic compounds directed against trafficking of leukocytes have been designed and are being developed as a novel class of drugs in the treatment of Crohn's disease and ulcerative colitis. This review deals with the immunological aspects of leukocyte trafficking focused on gut homing of T cells. Second, the changes in adhesion molecules and T cell trafficking during intestinal inflammation are discussed. Finally, we review the clinical data that have been gathered with respect to the therapeutic potential and the safety of antiadhesion molecule treatment. Antegren, or natalizumab, a humanized anti-α4 integrin IgG4 antibody, has been most extensively evaluated and may be close to registration. A more specific humanized α4β7-integrin MLN-02 has shown preliminary clinical efficacy in ulcerative colitis, and both antergren and MLN-02 appear to be very safe. Trials with the anti-ICAM-1 antisense oligonucleotide ISIS-2302 in steroid refractory Crohn's disease have provided conflicting efficacy data. In the near future, some of these novel biological agents may prove valuable therapeutic tools in the management of refractory inflammatory bowel disease, although it is too early to define the patient population that will benefit most from these agents.

Mucosal cytokine expression, cellular markers and adhesion molecules in inflammatory bowel disease

1999 ◽  
Vol 11 (3) ◽  
pp. 267-276 ◽  
Author(s):  
Alexander Woywodt ◽  
Diether Ludwig ◽  
Petra Neustock ◽  
Andrea Kruse ◽  
Karsten Schwarting ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Adhesion Molecules ◽  
Bowel Disease ◽  
Cytokine Expression ◽  
Inflammatory Bowel ◽  
Cellular Markers

Elevated serum concentrations of soluble selectin and immunoglobulin type adhesion molecules in patients with inflammatory bowel disease

1997 ◽  
Vol 32 (4) ◽  
pp. 480-486 ◽  
Author(s):  
Michael Göke ◽  
Jörg C. Hoffmann ◽  
Jörg Evers ◽  
Hartmut Krüger ◽  
Michael P. Manns
Keyword(s):  
Inflammatory Bowel Disease ◽  
Adhesion Molecules ◽  
Bowel Disease ◽  
Elevated Serum ◽  
Serum Concentrations ◽  
Inflammatory Bowel
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