Vitamin D enhances caspase-dependent and -independent TNF?-induced breast cancer cell death: The role of reactive oxygen species and mitochondria

2003 ◽  
Vol 106 (2) ◽  
pp. 178-186 ◽  
Author(s):  
Gregory E. Weitsman ◽  
Amiram Ravid ◽  
Uri A. Liberman ◽  
Ruth Koren
Keyword(s):  
Breast Cancer ◽  
Reactive Oxygen Species ◽  
Vitamin D ◽  
Cell Death ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Cancer Cell Death

scholarly journals AKT but not MYC promotes reactive oxygen species-mediated cell death in oxidative culture

2019 ◽  
Author(s):  
Dongqing Zheng ◽  
Jonathan H. Sussman ◽  
Matthew P. Jeon ◽  
Sydney T. Parrish ◽  
Alireza Delfarah ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Reactive Oxygen Species ◽  
Cell Death ◽  
Oxidative Phosphorylation ◽  
Cancer Cells ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Lines ◽  
Oxygen Species

ABSTRACTOncogenes can generate metabolic vulnerabilities in cancer cells. Here, we tested how AKT and MYC affect the ability of cells to shift between respiration and glycolysis. Using immortalized mammary epithelial cells, we discovered that constitutively active AKT but not MYC induced cell death in galactose culture, where cells must rely on oxidative phosphorylation for energy generation. However, the negative effects of AKT were short-lived, and AKT-expressing cells recommenced growth after ~15 days in galactose. To identify the mechanisms regulating AKT-mediated cell death, we used metabolomics and found that AKT cells dying in galactose upregulated glutathione metabolism. Next, using proteomics, we discovered that AKT-expressing cells dying in galactose upregulated nonsense-mediated mRNA decay, a marker of sensitivity to oxidative stress. We therefore measured levels of reactive oxygen species (ROS) and discovered that galactose induced ROS in cells expressing AKT but not MYC. Additionally, ROS were required for the galactose-induced death of AKT-expressing cells. We then tested whether these findings could be replicated in breast cancer cell lines with constitutively active AKT signaling. Indeed, we found that galactose induced rapid cell death in breast cancer cell lines and that ROS were required for galactose-induced cell death. Together, our results demonstrate that AKT but not MYC induces a metabolic vulnerability in cancer cells, namely the restricted flexibility to use oxidative phosphorylation.ImplicationsThe discovery that AKT but not MYC restricts the ability to utilize oxidative phosphorylation highlights that therapeutics targeting tumor metabolism must be tailored to the individual genetic profile of tumors.

scholarly journals Snake venom causes apoptosis by increasing the reactive oxygen species in colorectal and breast cancer cell lines

2016 ◽  
Vol Volume 9 ◽  
pp. 6485-6498 ◽  
Author(s):  
Abdulrahman Al-Asmari ◽  
Riyasdeen Anvarbatcha ◽  
Mohammad Al-Shahrani ◽  
Mozaffarul Islam
Keyword(s):  
Breast Cancer ◽  
Reactive Oxygen Species ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Snake Venom ◽  
Reactive Oxygen ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Oxygen Species

scholarly journals Bioactivation of Napabucasin Triggers Reactive Oxygen Species–Mediated Cancer Cell Death

2019 ◽  
Vol 25 (23) ◽  
pp. 7162-7174 ◽  
Author(s):  
Fieke E.M. Froeling ◽  
Manojit Mosur Swamynathan ◽  
Astrid Deschênes ◽  
Iok In Christine Chio ◽  
Erin Brosnan ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Cancer Cell ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Cancer Cell Death

Abstract 3801: Role of microRNAs in resveratrol induced breast cancer cell death

2015 ◽  
Author(s):  
Rajkumar Venkatadri ◽  
Clayton Wright ◽  
Vivek Kaushik ◽  
Yogesh Kulkarni ◽  
Juan Sebastian Yakisich ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Death

scholarly journals Statin-Induced Breast Cancer Cell Death: Role of Inducible Nitric Oxide and Arginase-Dependent Pathways

2007 ◽  
Vol 67 (15) ◽  
pp. 7386-7394 ◽  
Author(s):  
Srigiridhar Kotamraju ◽  
Carol L. Willams ◽  
Balaraman Kalyanaraman
Keyword(s):  
Breast Cancer ◽  
Nitric Oxide ◽  
Cell Death ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Death ◽  
Inducible Nitric Oxide

scholarly journals Role of apoptosis-related miRNAs in resveratrol-induced breast cancer cell death

2016 ◽  
Vol 7 (2) ◽  
pp. e2104-e2104 ◽  
Author(s):  
R Venkatadri ◽  
T Muni ◽  
A K V Iyer ◽  
J S Yakisich ◽  
N Azad
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Death

scholarly journals An Increase in Reactive Oxygen Species by Deregulation of ARNT Enhances Chemotherapeutic Drug-Induced Cancer Cell Death

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e99242 ◽  
Author(s):  
Jiunn-Min Shieh ◽  
Chih-Jie Shen ◽  
Wei-Chiao Chang ◽  
Hung-Chi Cheng ◽  
Ya-Yi Chan ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Death ◽  
Cancer Cell ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Chemotherapeutic Drug ◽  
Drug Induced ◽  
Cancer Cell Death
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