Successful cancer vaccine therapy for carcinoembryonic antigen (CEA)-expressing colon cancer using genetically modified dendritic cells that express CEA and T helper-type 1 cytokines in CEA transgenic mice

International Journal of Cancer ◽

10.1002/ijc.22298 ◽

2006 ◽

Vol 120 (3) ◽

pp. 585-593 ◽

Author(s):

Toshiyasu Ojima ◽

Makoto Iwahashi ◽

Masaki Nakamura ◽

Kenji Matsuda ◽

Mikihito Nakamori ◽

...

Keyword(s):

Colon Cancer ◽

Dendritic Cells ◽

Transgenic Mice ◽

Carcinoembryonic Antigen ◽

Cancer Vaccine ◽

Genetically Modified ◽

Vaccine Therapy ◽

T Helper ◽

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Humoral and T helper cell responses elicited by immunization with dendritic cells genetically modified with an adenoviral vector expressing HCV NS3 protein in HLA-A2.1 transgenic mice

Zeitschrift für Gastroenterologie ◽

10.1055/s-2006-931768 ◽

2006 ◽

Vol 44 (01) ◽

Author(s):

M Xiang ◽

C Eisenbach ◽

CM Lupu ◽

E Ernst ◽

W Stremmel ◽

...

Keyword(s):

Dendritic Cells ◽

Transgenic Mice ◽

Adenoviral Vector ◽

Genetically Modified ◽

T Helper Cell ◽

Helper Cell ◽

T Helper ◽

Cell Responses ◽

Ns3 Protein ◽

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Differential Enhancement of T Helper Type 1 (Th1)/Th2 Cytokine Production by Natural Killer T Cells Through Negative Feedback Regulation with Cytokine-conditioned Dendritic Cells

Current Immunology Reviews ◽

10.2174/157339510791111745 ◽

2010 ◽

Vol 6 (2) ◽

pp. 78-87

Author(s):

Kazuya Iwabuchi ◽

Yoshiki Yanagawa ◽

Keita Minami ◽

Kazuomi Mizuuchi ◽

Masanori Maeda ◽

...

Keyword(s):

Dendritic Cells ◽

Cytokine Production ◽

Feedback Regulation ◽

Natural Killer T Cells ◽

T Helper ◽

Negative Feedback Regulation ◽

Th2 Cytokine ◽

Killer T Cells ◽

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60-kDa heat shock protein of Chlamydia pneumoniae promotes a T helper type 1 immune response through IL-12/IL-23 production in monocyte-derived dendritic cells

Microbes and Infection ◽

10.1016/j.micinf.2005.09.007 ◽

2006 ◽

Vol 8 (3) ◽

pp. 714-720 ◽

Author(s):

Clara Maria Ausiello ◽

Giorgio Fedele ◽

Raffaella Palazzo ◽

Fabiana Spensieri ◽

Alessandra Ciervo ◽

...

Keyword(s):

Immune Response ◽

Dendritic Cells ◽

Heat Shock Protein ◽

Chlamydia Pneumoniae ◽

T Helper ◽

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Upregulation of the CLIP self peptide on mature dendritic cells antagonizes T helper type 1 polarization

Nature Immunology ◽

10.1038/ni1108 ◽

2004 ◽

Vol 5 (9) ◽

pp. 909-918 ◽

Author(s):

Till A Röhn ◽

Marianne Boes ◽

Dirk Wolters ◽

Sebastian Spindeldreher ◽

Bernd Müller ◽

...

Keyword(s):

Dendritic Cells ◽

T Helper ◽

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Selected commensal-related bacteria and Toll-like receptor 3 agonist combinatorial codes synergistically induce interleukin-12 production by dendritic cells to trigger a T helper type 1 polarizing programme

10.1111/j.1365-2567.2008.03022.x ◽

2009 ◽

Vol 128 (1pt2) ◽

pp. e523-e531 ◽

Author(s):

Nobuyasu Baba ◽

Sandrine Samson ◽

Raphaëlle Bourdet-Sicard ◽

Manuel Rubio ◽

Marika Sarfati

Keyword(s):

Dendritic Cells ◽

Interleukin 12 ◽

Toll Like Receptor ◽

T Helper ◽

Combinatorial Codes ◽

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Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses

Nature Immunology ◽

10.1038/ni.1707 ◽

2009 ◽

Vol 10 (4) ◽

pp. 394-402 ◽

Author(s):

Hideki Nakano ◽

Kaifeng Lisa Lin ◽

Manabu Yanagita ◽

Chantal Charbonneau ◽

Donald N Cook ◽

...

Keyword(s):

Dendritic Cells ◽

Immune Responses ◽

Lymph Nodes ◽

T Helper ◽

Inflammatory Dendritic Cells ◽

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Faculty Opinions recommendation of Viral-induced T helper type 1 responses enhance allergic disease by effects on lung dendritic cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1017856.207477 ◽

2004 ◽

Author(s):

Dan Conrad

Keyword(s):

Dendritic Cells ◽

Allergic Disease ◽

T Helper ◽

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Faculty Opinions recommendation of Upregulation of the CLIP self peptide on mature dendritic cells antagonizes T helper type 1 polarization.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1022034.250643 ◽

2004 ◽

Author(s):

Elizabeth Mellins

Keyword(s):

Dendritic Cells ◽

T Helper ◽

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DHMEQ, a novel nuclear factor-κB inhibitor, induces selective depletion of alloreactive or phytohaemagglutinin-stimulated peripheral blood mononuclear cells, decreases production of T helper type 1 cytokines, and blocks maturation of dendritic cells

10.1111/j.1365-2567.2007.02755.x ◽

2008 ◽

Vol 124 (2) ◽

pp. 198-205 ◽

Author(s):

Chie Nishioka ◽

Takayuki Ikezoe ◽

Yang Jing ◽

Kazuo Umezawa ◽

Akihito Yokoyama

Keyword(s):

Dendritic Cells ◽

Mononuclear Cells ◽

Nuclear Factor Κb ◽

Nuclear Factor ◽

T Helper ◽

Peripheral Blood Mononuclear ◽

Blood Mononuclear Cells ◽

Selective Depletion ◽

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CC chemokine ligand 2 down-modulation by selected Toll-like receptor agonist combinations contributes to T helper 1 polarization in human dendritic cells

Blood ◽

10.1182/blood-2009-01-199406 ◽

2009 ◽

Vol 114 (4) ◽

pp. 796-806 ◽

Author(s):

Manuela Del Cornò ◽

Alessandro Michienzi ◽

Andrea Masotti ◽

Letizia Da Sacco ◽

Gian Franco Bottazzo ◽

...

Keyword(s):

Dendritic Cells ◽

Interleukin 12 ◽

Toll Like Receptor ◽

T Helper ◽

Cc Chemokine ◽

Chemokine Ligand ◽

Cc Chemokine Ligand 2 ◽

Chemokine Ligand 2 ◽

Abstract Toll-like receptor (TLR) signaling activation by pathogens is critical to the induction of immune responses, and demands tight regulation. We describe in this study that CC chemokine ligand 2 (CCL2) secretion triggered by TLR4 or TLR8 engagement is strongly inhibited upon simultaneous activation of both TLRs in human monocyte-derived dendritic cells (DCs). Impaired CCL2 secretion occurs concomitantly to interleukin-12 up-regulation, being part of a complex regulatory circuit ensuring optimal T helper type 1 polarization. Interestingly, triggering selected TLRs or their combinations differently affects nuclear factor-κB p65 activation and microRNA expression. Overall, these results indicate that CCL2 supplies an important immunomodulatory role to DCs, and may contribute to dictate the cytokine profile in T helper type 1 responses induced by DCs.

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