scholarly journals Phase II study of sunitinib malate, a multitargeted tyrosine kinase inhibitor in patients with relapsed or refractory soft tissue sarcomas. Focus on three prevalent histologies: Leiomyosarcoma, liposarcoma and malignant fibrous histiocytoma

2011 ◽  
Vol 129 (8) ◽  
pp. 1963-1969 ◽  
Author(s):  
S. Tariq Mahmood ◽  
Samuel Agresta ◽  
Carlos E. Vigil ◽  
Xiuhua Zhao ◽  
Gang Han ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitor ◽  
Phase Ii ◽  
Kinase Inhibitor ◽  
Phase Ii Study ◽  
Fibrous Histiocytoma ◽  
Soft Tissue Sarcomas ◽  
Sunitinib Malate ◽  
Multitargeted Tyrosine Kinase Inhibitor

scholarly journals Phase II Study of the Multitargeted Tyrosine Kinase Inhibitor XL647 in Patients with Non–Small-Cell Lung Cancer

2012 ◽  
Vol 7 (5) ◽  
pp. 856-865 ◽  
Author(s):  
M. Catherine Pietanza ◽  
Shirish M. Gadgeel ◽  
Afshin Dowlati ◽  
Thomas J. Lynch ◽  
Ravi Salgia ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tyrosine Kinase ◽  
Small Cell Lung Cancer ◽  
Tyrosine Kinase Inhibitor ◽  
Phase Ii ◽  
Kinase Inhibitor ◽  
Phase Ii Study ◽  
Small Cell ◽  
Small Cell Lung ◽  
Multitargeted Tyrosine Kinase Inhibitor

Effect of treatment with sunitinib malate, a multitargeted tyrosine kinase inhibitor, on circulating plasma levels of VEGF, soluble VEGF receptors 2 and 3, and soluble KIT in patients with metastatic breast cancer

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 578-578 ◽  
Author(s):  
S. E. Deprimo ◽  
C. Friece ◽  
X. Huang ◽  
J. Smeraglia ◽  
L. Sherman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitor ◽  
Plasma Levels ◽  
Kinase Inhibitor ◽  
Metastatic Breast ◽  
Response Analysis ◽  
Sunitinib Malate ◽  
Multitargeted Tyrosine Kinase Inhibitor

578 Background: Sunitinib malate (SU11248) is a multitargeted tyrosine kinase inhibitor with antitumor and antiangiogenic activity that specifically inhibits VEGFR, PDGFR, KIT, RET and FLT3. In a phase II trial of 64 patients with refractory, metastatic breast cancer, sunitinib treatment resulted in an ∼11% objective response rate (Miller et al, ASCO 2005). To characterize potential biomarkers of biological response to sunitinib, we analyzed plasma levels of a panel of soluble proteins from patients in this trial. Methods: Patients received sunitinib in 6-week cycles comprised of 50 mg/day for 4 weeks followed by 2 weeks off treatment. Pre-dose plasma samples from 62 patients were obtained on days 1, 14, and 28 of the first cycle and days 1 and 28 of subsequent cycles. Plasma levels of VEGF, soluble VEGF receptor 2 (sVEGFR-2), soluble KIT (sKIT), and a novel biomarker, sVEGFR-3, were measured via ELISA analysis. Results: Plasma levels of each protein were modulated in most patients during the course of treatment. At the end of the first cycle, VEGF levels were increased more than 3-fold relative to baseline in 73% of cases, while sVEGFR-2 levels decreased by at least 30% in 88% of cases, and by >20% in all but 4 cases. In addition, levels of sVEGFR-3 were decreased by >30% in 82% of cases during the first cycle. For each of these markers, levels tended to return to near-baseline after 2 weeks off treatment. Longitudinal decreases in sKIT were also observed; decreases >50% by the end of cycle 2 were correlated with treatment outcomes for time-to-progression (P < 0.001) and survival (P = 0.03). Further analysis of correlations with pharmacokinetic and clinical parameters is ongoing. Conclusions: Sunitinib therapy is associated with increases in plasma VEGF and decreases in soluble VEGFRs and KIT. This panel of circulating proteins may have utility as pharmacodynamic biomarkers of sunitinib activity in patients with metastatic breast cancer. sVEGFR-3 may be a novel biomarker of the biological activity of sunitinib, while sKIT may be correlated with clinical response. Analysis of these and other biomarkers in larger studies of sunitinib in breast cancer may be warranted. [Table: see text]

scholarly journals A Phase II Study of Pembrolizumab in EGFR-Mutant, PD-L1+, Tyrosine Kinase Inhibitor Naïve Patients With Advanced NSCLC

2018 ◽  
Vol 13 (8) ◽  
pp. 1138-1145 ◽  
Author(s):  
A. Lisberg ◽  
A. Cummings ◽  
J.W. Goldman ◽  
K. Bornazyan ◽  
N. Reese ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitor ◽  
Phase Ii ◽  
Advanced Nsclc ◽  
Kinase Inhibitor ◽  
Phase Ii Study ◽  
Egfr Mutant

Phase II study of sunitinib malate (SM) in subjects with metastatic and/or surgically unresectable non-GIST soft tissue sarcomas

2008 ◽  
Vol 26 (15_suppl) ◽  
pp. 10535-10535 ◽  
Author(s):  
C. E. Vigil ◽  
A. A. Chiappori ◽  
C. A. Williams ◽  
H. H. Shrager ◽  
B. L. Murray ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Phase Ii ◽  
Phase Ii Study ◽  
Soft Tissue Sarcomas ◽  
Sunitinib Malate

A phase II study of pembrolizumab in EGFR-mutant, PD-L1+, tyrosine kinase inhibitor (TKI) naïve patients with advanced NSCLC.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. 9014-9014 ◽  
Author(s):  
Aaron Elliott Lisberg ◽  
Amy Lauren Cummings ◽  
Jonathan Wade Goldman ◽  
Krikor Bornazyan ◽  
Nicholas Dean Reese ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitor ◽  
Phase Ii ◽  
Advanced Nsclc ◽  
Kinase Inhibitor ◽  
Phase Ii Study ◽  
Egfr Mutant
Sign in / Sign up

Export Citation Format

Share Document