scholarly journals Molecular dissection of the agonist binding site of an AMPA receptor.

1995 ◽  
Vol 14 (24) ◽  
pp. 6327-6332 ◽  
Author(s):  
A. Kuusinen ◽  
M. Arvola ◽  
K. Keinänen
Keyword(s):  
Binding Site ◽  
Ampa Receptor ◽  
Molecular Dissection ◽  
Agonist Binding

scholarly journals A Domain Linking the AMPA Receptor Agonist Binding Site to the Ion Pore Controls Gating and Causes lurcher Properties when Mutated

2007 ◽  
Vol 27 (45) ◽  
pp. 12230-12241 ◽  
Author(s):  
S. M. Schmid ◽  
C. Korber ◽  
S. Herrmann ◽  
M. Werner ◽  
M. Hollmann
Keyword(s):  
Binding Site ◽  
Ampa Receptor ◽  
Receptor Agonist ◽  
Agonist Binding ◽  
Ion Pore

Homology modeling in tandem with 3D-QSAR analyses: A computational approach to depict the agonist binding site of the human CB2 receptor

2011 ◽  
Vol 46 (9) ◽  
pp. 4489-4505 ◽  
Author(s):  
Elena Cichero ◽  
Alessia Ligresti ◽  
Marco Allarà ◽  
Vincenzo di Marzo ◽  
Zelda Lazzati ◽  
...  
Keyword(s):  
Homology Modeling ◽  
Binding Site ◽  
3D Qsar ◽  
Computational Approach ◽  
Agonist Binding ◽  
Cb2 Receptor

scholarly journals Ligand Binding at the α4-α4 Agonist-Binding Site of the α4β2 nAChR Triggers Receptor Activation through a Pre-Activated Conformational State

PLoS ONE ◽  
2016 ◽  
Vol 11 (8) ◽  
pp. e0161154 ◽  
Author(s):  
Dinesh C. Indurthi ◽  
Trevor M. Lewis ◽  
Philip K. Ahring ◽  
Thomas Balle ◽  
Mary Chebib ◽  
...  
Keyword(s):  
Ligand Binding ◽  
Binding Site ◽  
Receptor Activation ◽  
Conformational State ◽  
Agonist Binding

scholarly journals Glutamate receptor antibodies activate a subset of receptors and reveal an agonist binding site

Neuron ◽  
1995 ◽  
Vol 14 (4) ◽  
pp. 755-762 ◽  
Author(s):  
Roy E Twyman ◽  
Lorise C Gahring ◽  
Joachim Spiess ◽  
Scott W Rogers
Keyword(s):  
Binding Site ◽  
Glutamate Receptor ◽  
Agonist Binding ◽  
Receptor Antibodies

scholarly journals Activation Kinetics of AMPA Receptor Channels Reveal the Number of Functional Agonist Binding Sites

1998 ◽  
Vol 18 (1) ◽  
pp. 119-127 ◽  
Author(s):  
John D. Clements ◽  
Anne Feltz ◽  
Yoshinori Sahara ◽  
Gary L. Westbrook
Keyword(s):  
Ampa Receptor ◽  
Binding Sites ◽  
Agonist Binding ◽  
Activation Kinetics ◽  
Kinetics Of ◽  
Ampa Receptor Channels

scholarly journals Mapping the Agonist Binding Site of the GABAAReceptor: Evidence for a β-Strand

1999 ◽  
Vol 19 (12) ◽  
pp. 4847-4854 ◽  
Author(s):  
Andrew J. Boileau ◽  
Amy R. Evers ◽  
Anson F. Davis ◽  
Cynthia Czajkowski
Keyword(s):  
Binding Site ◽  
Agonist Binding

Structural elements involved in activation of the γ-aminobutyric acid type A (GABAA) receptor

2004 ◽  
Vol 32 (3) ◽  
pp. 540-546 ◽  
Author(s):  
T.L. Kash ◽  
J.R. Trudell ◽  
N.L. Harrison
Keyword(s):  
Ion Channels ◽  
Ion Channel ◽  
Binding Site ◽  
Type A ◽  
Aminobutyric Acid ◽  
Structural Elements ◽  
Agonist Binding ◽  
Acid Type ◽  
Gated Ion Channels ◽  
Ligand Gated Ion Channels

Ligand-gated ion channels function as rapid signal transducers, converting chemical signals (in the form of neurotransmitters) into electrical signals in the postsynaptic neuron. This is achieved by the recognition of neurotransmitter at its specific-binding sites, which then triggers the opening of an ion channel (‘gating’). For this to occur rapidly (<1 ms), there must be an efficient coupling between the agonist-binding site and the gate, located more than 30 Å (1 Å=0.1 nm) away. Whereas a great deal of progress has been made in elucidating the structure and function of both the agonist-binding site and the ion permeation pathway in ligand-gated ion channels, our knowledge of the coupling mechanism between these domains has been limited. In this review, we summarize recent studies of the agonist-binding site and the ion channel in the γ-aminobutyric acid type A receptor, and discuss those structural elements that may mediate coupling between them. We will also consider some possible molecular mechanisms of receptor activation.

AMPA Receptor Noncompetitive Inhibitors Occupy a Promiscuous Binding Site

2019 ◽  
Vol 10 (11) ◽  
pp. 4511-4521 ◽  
Author(s):  
Chamali Narangoda ◽  
Serzhan N. Sakipov ◽  
Maria G. Kurnikova
Keyword(s):  
Binding Site ◽  
Ampa Receptor ◽  
Noncompetitive Inhibitors
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