Effects of Traxanox Sodium on Blood Pressure and Serum Uric Acid in Hypertensive Patients: A Preliminary Study

1989 ◽  
Vol 29 (4) ◽  
pp. 327-330
Author(s):  
Akio Fujimura ◽  
Akio Ebihara ◽  
Naoko Hino ◽  
Yuichi Koike
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Hypertensive Patients ◽  
Preliminary Study

Relação entre Ácido Úrico Sérico e Capacidade Antioxidante em uma População de Hipertensos Atendidos em Unidade Básica de Saúde do Sul de Minas Gerais/ Relation between Serum Uric Acid and Antioxidant Capacity in a Population of Hypertensive Patients in a

1970 ◽  
Vol 3 (4) ◽  
pp. 47-58
Author(s):  
Hélida Márcia Pinelli ◽  
Kalina Tondato De Paula e Silva ◽  
Thiago Fernandes Marques ◽  
Stéphanie de Araújo Costa ◽  
Lázaro Alessandro Soares Nunes
Keyword(s):  
Blood Pressure ◽  
Antioxidant Activity ◽  
Uric Acid ◽  
Antioxidant Capacity ◽  
Serum Uric Acid ◽  
Antioxidant Status ◽  
Urine Samples ◽  
Uric Acid Concentration ◽  
Hypertensive Patients ◽  
Serum Uric Acid Concentration

Objetivo: Investigar a relação entre os níveis séricos de ácido úrico e capacidade antioxidante com a pressão arterial em indivíduos hipertensos. Métodos: Foram coletados sangue e amostras de urina isolada de 76 sujeitos (21-65 anos) provenientes de unidade básica de saúde. Antes da coleta a pressão arterial foi aferida e os sujeitos foram divididos em três grupos: normotensos (N); hipertensos controlados (HC) e hipertensos não-controlados (HNC). Foram determinadas as concentrações séricas de ácido úrico, ureia, creatinina e capacidade antioxidante. Proteínas totais e creatinina foram determinadas em urina isolada. Resultados: Os valores médios de ácido úrico foram significativamente elevados no grupo HC (mulheres = 5,64±1,2mg/dL; homens = 6,1±2,6mg/dL)  comparados aos normotensos (mulheres = 4,1±1,1mg/dL; homens = 5,1±1,8mg/dL) e HNC (mulheres = 4,82±1,1mg/dL; homens = 5,8±1,8mg/dL), p<0,001. Os valores de capacidade antioxidante expressos em μmol equivalentes Trolox/L foram significativamente maiores nos indivíduos usuários de inibidores da enzima conversora de angiotensina - IECA (690,9 ± 205,9) em comparação aos normotensos (568,0 ± 163,0) e usuários de outras classes de anti-hipertensivos (645,1 ± 145,0), p<0,01. Conclusão: Embora neste estudo o ácido úrico esteja elevado nos hipertensos, sua ação antioxidante pode contribuir diretamente para a diminuição do estresse oxidativo.    Palavras Chave: hipertensão, hiperuricemia, capacidade antioxidante  Objective: To investigate the relation between serum uric acid concentration and antioxidant status with blood pressure levels (BP) in hypertensive individuals. Methods: Blood and urine samples from 76 ambulatory patients (21-65 years-old) were analyzed. Based on the history and blood pressure levels, patients were divided into three groups: normal blood pressure (n=36), controlled hypertension (n=18) and not controlled hypertension (n=22). We analyzed urea, creatinine and serum antioxidant capacity from blood samples and proteins and creatinine from urine samples. Results: Controlled hypertension group had significantly higher blood uric acid (male=6,1±2,6mg/dl; female=5,64±1,2mg/dl) than normal (male=5,1±1,8mg/dl; female=4,1±1,1mg/dl) and not controlled blood pressure group (male=5,8±1,8mg/dl; female=4,8±1,1mg/dl; p<0,001). There was no correlation between uric acid and blood pressure. The values of antioxidant activity expressed in μmol equivalent Trolox/L were significantly higher in individuals treated with angiotensin converting enzyme (ACE) inhibitors (690,9 ± 205,9) than normotensive (568,0 ± 163,0) and users of other antihypertensive drugs (645,1 ± 145,0), p<0,01. Conclusion: Although in  this study the uric acid is high in the hypertensive patients, its antioxidant activity may contribute directly to the reduction of oxidative stress.   Keywords: hypertension, hyperuricemia, antioxidant status.

scholarly journals Serum Uric Acid Level, Longitudinal Blood Pressure, Renal Function, and Long-Term Mortality in Treated Hypertensive Patients

Hypertension ◽  
2013 ◽  
Vol 62 (1) ◽  
pp. 105-111 ◽  
Author(s):  
Jesse Dawson ◽  
Panniyammakal Jeemon ◽  
Lucy Hetherington ◽  
Caitlin Judd ◽  
Claire Hastie ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renal Function ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Hypertensive Patients ◽  
Long Term Mortality

scholarly journals Effect of losartan combined with amlodipine or with a thiazide on uric acid levels in hypertensive patients

2016 ◽  
Vol 11 (2) ◽  
pp. 57-62 ◽  
Author(s):  
Alberto F. Rubio-Guerra ◽  
Ana K. Garro-Almendaro ◽  
Cesar I. Elizalde-Barrera ◽  
Juan A. Suarez-Cuenca ◽  
Montserrat B. Duran-Salgado
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Repeated Measures ◽  
Antihypertensive Drugs ◽  
Metabolic Risk ◽  
Hypertensive Patients ◽  
Few Data ◽  
Group Serum

Hyperuricemia leads to endothelial dysfunction and insulin resistance, and has been associated with diseases such as hypertension. Antihypertensive drugs modify serum uric acid levels, however, few data are available about their combinations on uricemia. In this study we evaluate the effect of two combinations of losartan, with amlodipine or with hydrochlorothiazide, on serum uric acid levels in hypertensive patients. Methods: A total of 60 hypertensive patients were randomized in two groups; group LA received losartan/amlodipine (100/5 mg) once a day, whereas LH group received losartan hydrochlorothiazide (100/12.5 mg) once a day for 3 months. In both groups serum uric acid levels were measured at the beginning and end of the study. Patients were evaluated monthly for blood pressure (BP) and adverse events. Statistical analysis was performed with a two-way analysis of variance (ANOVA) for repeated measures. Results: All patients experienced a significant reduction of BP to the same extent (LA 155/94 to 123/79, LH 157/92 to 124/78 mmHg, p > 0.05). In the LA group, serum uric acid decreased from 6.5 ± 1.6 to 4.6 ± 1.3 mg/ml ( p = 0.0001), whereas in the LH group there was a nonsignificant increase from 5.82 ± 1.4 to 5.85 ± 1.5 mg/ml, ( p = 0.936). When both groups were compared, we found a significant reduction ( p < 0.00013) on serum uric acid levels in the LA group. Conclusions: Both combinations decrease BP values to the same extent, however, LA combination showed a reduction on serum uric acid levels, which may contribute to a reduction in the metabolic risk in hypertensive patients.

scholarly journals FREQUENCY OF HYPERURICEMIA IN HYPERTENSIVE PATIENTS AND ITS ASSOCIATION WITH AGE OF PATIENT

2021 ◽  
Vol 71 (1) ◽  
pp. 304-08
Author(s):  
Syed Saif Ul Hassan Shah ◽  
Usman Iqbal ◽  
Ejaz Ahmad
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Analytical Study ◽  
Serum Uric Acid Level ◽  
Military Hospital ◽  
Cross Sectional ◽  
Hypertensive Patients ◽  
Male Preponderance ◽  
Chemical Analyzer

Objective: To determine the frequency of hyperuricemia in hypertensive patients and its association with the age of patients. Study Design: Cross sectional analytical study. Place and Duration of Study: Combined Military Hospital Abbottabad, from Sep 2016 to Feb 2017. Methodology: All patients of 18-70 years of age with either gender presenting in and out patient departmentswith hypertension were enrolled. Serum uric acid was measured. Analysis of serum uric was done with SelectraXL chemical analyzer having normal references range of 2.52-6.97 mg/dl for males and 1.51-6.0 mg/dl forfemales. Reports were verified by Pathologist. Results: A total of 137 patients were selected for the study. Mean age of the patients was 56.09 ± 09.36 years.There were 76 (55.50%) patients with >55 years of age while 61 (44.50%) patients were presented with ≤55 years of the patients. Male preponderance was higher 83 (61%) as compared to females 54 (39%). Mean weight, height and Body Mass Index of the patients was 67.99 ± 6.91 kilograms, 1.63 ± 0.08 meters and 25.32 ± 2.15 kg/m2 respectively. Mean systolic blood pressure of the patients was 166.71 ± 13.67 mmHg. Mean Diastolic blood pressure was 100.15 ± 8.84 mmHg. Mean serum uric acid level was 6.96 ± 0.82 mg/dl. Frequency of hyperuricemia was found in 102 (74.45%) while normouricemia in 35 (25.55%) patients. Conclusion: Frequency of hyperuricemia was found higher in hypertensive patients and it was not associatedwith the age of patients.

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