Migration of polyethylene wear debris in hip arthroplasties: A canine model

1995 ◽  
Vol 6 (4) ◽  
pp. 225-230 ◽  
Author(s):  
W. J. Kraemer ◽  
G. L. Maistrelli ◽  
V. Fornasier ◽  
A. Binnington ◽  
J. F. Zhao
Keyword(s):  
Wear Debris ◽  
Polyethylene Wear ◽  
Canine Model ◽  
Hip Arthroplasties

Bio-Ferrography to Capture and Separate Polyethylene Wear Debris from Hip Simulator Fluid and Compared with Conventional Filter Method

2005 ◽  
Vol 128 (2) ◽  
pp. 436-441 ◽  
Author(s):  
Donna M. Meyer ◽  
Adam Tillinghast ◽  
Nevan C. Hanumara ◽  
Ana Franco
Keyword(s):  
Experimental Method ◽  
Bovine Serum ◽  
Wear Debris ◽  
Polyethylene Wear ◽  
Ultrahigh Molecular Weight Polyethylene ◽  
Filter Method ◽  
Acetabular Cup ◽  
Serum Samples ◽  
Uhmwpe Wear ◽  
Uhmwpe Particle

This paper describes an experimental method, bio-ferrography, to separate ultrahigh molecular weight polyethylene (UHMWPE) wear debris, generated in hip simulators, from bovine serum lubricating fluid. A total of 54 experiments were performed in which an enzyme digestion “cocktail” was developed and used to clean the bovine serum samples of extraneous sugars, proteins, and lipids that interfere with the UHMWPE particle separation. Erbium chloride was used to marginally magnetize particles in the fluid prior to passing through the ferrographic device. The particles were captured and separated from the fluid by traversing the treated serum across a magnetic gap of a bio-ferrograph. Morphology of the captured and separated wear debris was compared with particles from samples of fluid filtered through a paper sieve arrangement with pores of 0.05micrometers in diameter. The UHMWPE wear debris collected using the described experimental method, were found to be between 0.1 and 20micrometers in diameter with spherical and pill-shaped particles. The filtered UHMWPE particles were in the same size range as the debris separated using bio-ferrography. To show that the experimental method captured UHMWPE particles, the spectra of the chemical composition of UHMWPE from an acetabular cup insert of a hip implant and of UHMWPE particles separated using bio-ferrography were compared and found to be the same. To further demonstrate that polyethylene could be captured and separated through the experimental method, manufactured polyethylene microspheres in the diameter range of 3-45micrometers, were captured and separated using the bio-ferrographic process.

Can centrifugation affect the morphology of polyethylene wear debris?

Wear ◽  
2008 ◽  
Vol 265 (11-12) ◽  
pp. 1914-1917 ◽  
Author(s):  
E. Zolotarevova ◽  
Z. Fejfarkova ◽  
G. Entlicher ◽  
M. Lapcikova ◽  
M. Slouf ◽  
...  
Keyword(s):  
Wear Debris ◽  
Polyethylene Wear

In situ complement activation by polyethylene wear debris

2000 ◽  
Vol 54 (1) ◽  
pp. 12-19 ◽  
Author(s):  
David H. DeHeer ◽  
James A. Engels ◽  
Aaron S. DeVries ◽  
Robert H. Knapp ◽  
John D. Beebe
Keyword(s):  
Complement Activation ◽  
Wear Debris ◽  
Polyethylene Wear

Ultra-High Molecular Weight Polyethylene Wear Debris Generated in Vivo and in Laboratory Tests; the Influence of Counterface Roughness

1996 ◽  
Vol 210 (1) ◽  
pp. 3-10 ◽  
Author(s):  
J L Hailey ◽  
E Ingham ◽  
M Stone ◽  
B M Wroblewski ◽  
J Fisher
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Wear Debris ◽  
Laboratory Tests ◽  
Polyethylene Wear ◽  
Uhmwpe Wear ◽  
Major Variable ◽  
Ultra High Molecular Weight ◽  
Counterface Roughness

The objective of this study was to investigate the effect of counterface roughness and lubricant on the morphology of ultra-high molecular weight polyethylene (UHMWPE) wear debris generated in laboratory wear tests, and to compare this with debris isolated from explanted tissue. Laboratory tests used UHMWPE pins sliding against stainless steel counterfaces. Both water and serum lubricants were used in conjunction with rough and smooth counterfaces. The lubricants and tissue from revision hip surgery were processed to digest the proteins and permit filtration. This involved denaturing the proteins with potassium hydroxide (KOH), sedimentation of any remaining proteins, and further digestion of these proteins with chromic acid. All fractions were then passed through a 0.2 μm membrane, and the debris examined using scanning electron microscopy. The laboratory studies showed that the major variable influencing debris morphology was counterface roughness. The rougher counter-faces produced larger numbers of smaller particles, with a size range extending below 1 μm. For smooth counterfaces there were fewer of these small particles, and evidence of larger platelets, greater than 10 μm in diameter. Analysis of the debris from explanted tissues showed a wide variation in the particle size distribution, ranging from below 1 μm up to several millimetres in size. Of major clinical significance in relation to osteolysis and loosening is roughening of the femoral components, which may lead to greater numbers of the sub-micron-sized particles.

scholarly journals Articular Cartilage Wear Characterization With a Particle Sizing and Counting Analyzer

2012 ◽  
Author(s):  
Sevan R. Oungoulian ◽  
Orian Bortz ◽  
Kristin E. Hehir ◽  
Kaicen Zhu ◽  
Clark T. Hung ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Friction Coefficient ◽  
Wear Debris ◽  
Polyethylene Wear ◽  
Quantitative Measurements ◽  
Diarthrodial Joints ◽  
Cartilage Wear ◽  
Tangential Forces ◽  
Fluid Pressurization

The primary function of articular cartilage is to serve as the bearing material in diarthrodial joints, transmitting loads while minimizing friction and wear. The friction coefficient of cartilage has been characterized extensively in the literature, using standard measurements of normal and tangential forces acting across a sliding interface [1]. However, quantitative measurements of cartilage wear have proven to be more challenging, with only a few studies having reported such measurements. The primary quantitative approaches proposed to date include biochemical assaying of cartilage and test solutions [2], and characterization of changing articular layer thickness [3] and surface roughness [4]. One study examining polyethylene wear debris in hip arthroplasty reported the use of an automated particle analyzer [5]. The aim of this study was to test the hypothesis that latest-generation particle analyzers are capable of detecting cartilage wear debris generated during in vitro loading experiments that last 24 h or less, by producing measurable content significantly above background noise levels. The longer-term objective of our studies is to test the hypothesis that elevated interstitial fluid pressurization, which is known to reduce the friction coefficient of cartilage [6], also reduces cartilage wear.

Hydroxyapatite-Coated Femoral Stem Survivorship at 10 Years

2005 ◽  
Vol 284-286 ◽  
pp. 1069-0 ◽  
Author(s):  
Gregory Y. Lee ◽  
Ajay Srivastava ◽  
Darryl D. D'Lima ◽  
Pam Pulido ◽  
Clifford W. Colwell
Keyword(s):  
Polyethylene Wear ◽  
Femoral Stem ◽  
Senior Author ◽  
Independent Observer ◽  
Long Term Follow Up ◽  
The Mean ◽  
Lost To Follow Up ◽  
Hip Arthroplasties

The Omnifit-HA femoral stem component has shown excellent results in early clinical studies. This is an independent prospective study of the outcome of a ydroxyapatite-coated femoral component implanted by one surgeon with an intermediate-term follow up. The senior author performed 103 consecutive uncemented total hip arthroplasties in 96 patients from July 1991 to December 1996. The components implanted were the Omnifit-HA femoral stem and the Omnifit PSL porous-coated acetabular shell. The mean age at the time of the index procedure was 52 years old (range, 27–78) and male:female ratio was 54:42. Three patients were deceased and four patients were lost to follow-up. The mean follow up was 10.3 years (range, 7.3–12.7 years). Clinical and radiographic evaluations were performed by an independent observer. The average preoperative and postoperative Harris Hip Scores were 55 and 92, respectively. The overall survivorship of the Omnifit-HA stem was 100% with no femoral revisions. The survivorship of the Omnifit PSL cup was 89.7% with 4 acetabular revisions for aseptic loosening and 6 polyethelene liner exchanges for osteolysis or late instability. The mean polyethylene wear rate was 0.24 mm per year. This long-term follow up shows that the use of circumferentially coated hydroxyapatite stems can protect against the migration of wear debris along the femoral stem.

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