Toxicity of polymer‐modified CuS nanoclusters on zebrafish embryo development

2021 ◽  
Author(s):  
Qiuping Zhang ◽  
Lifeng Wang ◽  
Qian Gao ◽  
Xinge Zhang ◽  
Yushuang Lin ◽  
...  
Keyword(s):  
Embryo Development ◽  
Zebrafish Embryo

Cyclin-dependent kinase 8 is expressed both maternally and zygotically during zebrafish embryo development

2002 ◽  
Vol 1576 (1-2) ◽  
pp. 203-208 ◽  
Author(s):  
Elaine D. Brabazon ◽  
Ronan T. Bree ◽  
Micheal W. Carton ◽  
Maura Grealy ◽  
Lucy Byrnes
Keyword(s):  
Embryo Development ◽  
Zebrafish Embryo ◽  
Cyclin Dependent Kinase

Pretilachlor has the potential to induce endocrine disruption, oxidative stress, apoptosis and immunotoxicity during zebrafish embryo development

2016 ◽  
Vol 42 ◽  
pp. 125-134 ◽  
Author(s):  
Jinhua Jiang ◽  
Yanhong Chen ◽  
Ruixian Yu ◽  
Xueping Zhao ◽  
Qiang Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endocrine Disruption ◽  
Embryo Development ◽  
Zebrafish Embryo

scholarly journals Zinc transporter ZIP10 forms a heteromer with ZIP6 which regulates embryonic development and cell migration

2016 ◽  
Vol 473 (16) ◽  
pp. 2531-2544 ◽  
Author(s):  
Kathryn M. Taylor ◽  
Issa A. Muraina ◽  
Dylan Brethour ◽  
Gerold Schmitt-Ulms ◽  
Thirayost Nimmanon ◽  
...  
Keyword(s):  
Cell Migration ◽  
Embryonic Development ◽  
Embryo Development ◽  
Mammalian Cells ◽  
Zebrafish Embryo ◽  
Zinc Transporter

Zinc is involved in cell migration during embryo development and in cancer. We show that a zinc transporter consisting of two proteins, ZIP6 and ZIP10, stimulates both cell migration and division in mammalian cells and in the zebrafish embryo.

scholarly journals Comparative assessment of the effects of bumped kinase inhibitors on early zebrafish embryo development and pregnancy in mice

2020 ◽  
Author(s):  
Nicoleta Anghel ◽  
Pablo A. Winzer ◽  
Dennis Imhof ◽  
Joachim Müller ◽  
Javier Langa ◽  
...  
Keyword(s):  
Pregnancy Outcome ◽  
Embryo Development ◽  
Mammalian Cells ◽  
Zebrafish Embryo ◽  
Kinase Inhibitors ◽  
Corn Oil ◽  
Neospora Caninum ◽  
Clear Correlation ◽  
Related Factors ◽  
The Impact

AbstractBumped kinase inhibitors (BKIs) are effective against a variety of apicomplexan parasites. Fifteen BKIs with promising in vitro efficacy against Neospora caninum tachyzoites, low cytotoxicity in mammalian cells, and no toxic effects in non-pregnant BALB/c mice, were assessed in pregnant mice. Drugs were emulsified in corn oil and applied by gavage for 5 days. Five BKIs did not affect pregnancy, 5 BKIs exhibited 15-35% of neonatal mortality, and 5 compounds caused strong effects (infertility, abortion, stillbirth and pup mortality). Additionally, the impact of these compounds on zebrafish (Danio rerio) embryo development was assessed by exposing freshly fertilized eggs to 0.2-50μM of BKIs and microscopical monitoring of embryo development in a blinded manner during 4 days. We propose an algorithm that includes quantification of malformations and embryo deaths, and established a scoring system that allows to calculate an impact score (Si) that indicates at which concentrations BKIs visibly affect zebrafish embryo development. Comparison of the two models showed that for 9 compounds no clear correlation between Si and pregnancy outcome was visible. However, those 3 BKIs affecting zebrafish embryos only at high concentrations (40μM or higher) did not impair mouse pregnancy at all, and those 3 compounds that inhibited zebrafish embryo development already at 0.2μM showed detrimental effects in the pregnancy model. Thus, the zebrafish embryo development test has a limited predictive value to foresee pregnancy outcome in BKI-treated mice. We conclude, that maternal health-related factors such as cardiovascular, pharmacokinetic and/or bioavailability properties also contribute to BKI-pregnancy effects.

C5-DNA Methyltransferase Inhibitors: From Screening to Effects on Zebrafish Embryo Development

ChemBioChem ◽  
2011 ◽  
Vol 12 (9) ◽  
pp. 1337-1345 ◽  
Author(s):  
Alexandre Ceccaldi ◽  
Arumugam Rajavelu ◽  
Christine Champion ◽  
Christine Rampon ◽  
Renata Jurkowska ◽  
...  
Keyword(s):  
Embryo Development ◽  
Dna Methyltransferase ◽  
Zebrafish Embryo ◽  
Dna Methyltransferase Inhibitors

scholarly journals Effects of low-concentration glyphosate and aminomethyl phosphonic acid on zebrafish embryo development

2021 ◽  
Vol 226 ◽  
pp. 112854
Author(s):  
Weidong Zhang ◽  
Jiachao Wang ◽  
Jianshi Song ◽  
Yanru Feng ◽  
Shujuan Zhang ◽  
...  
Keyword(s):  
Embryo Development ◽  
Phosphonic Acid ◽  
Zebrafish Embryo ◽  
Low Concentration ◽  
Aminomethyl Phosphonic Acid

scholarly journals An ensemble-averaged, cell density-based digital model of zebrafish embryo development derived from light-sheet microscopy data with single-cell resolution

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Andrei Y. Kobitski ◽  
Jens C. Otte ◽  
Masanari Takamiya ◽  
Benjamin Schäfer ◽  
Jonas Mertes ◽  
...  
Keyword(s):  
Single Cell ◽  
Cell Density ◽  
Embryo Development ◽  
Zebrafish Embryo ◽  
Light Sheet ◽  
Digital Model ◽  
Light Sheet Microscopy ◽  
Microscopy Data
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