scholarly journals Covalent surface modification of a titanium alloy with a phosphorylcholine-containing copolymer for reduced thrombogenicity in cardiovascular devices

2009 ◽  
Vol 91A (1) ◽  
pp. 18-28 ◽  
Author(s):  
Sang-Ho Ye ◽  
Carl A. Johnson ◽  
Joshua R. Woolley ◽  
Trevor A. Snyder ◽  
Lara J. Gamble ◽  
...  
2016 ◽  
Vol 879 ◽  
pp. 1552-1557
Author(s):  
C. Ramskogler ◽  
L. Cordero ◽  
Fernando Warchomicka ◽  
A.R. Boccaccini ◽  
Christof Sommitsch

An area of major interest in biomedical engineering is currently the development of improved materials for medical implants. Research efforts are being focused on the investigation of surface modification methods for metallic prostheses due to the fundamental bioinert character of these materials and the possible ion release from their surfaces, which could potentially induce the interfacial loosening of devices after implantation. Electron beam (EB) structuring is a novel technique to control the surface topography in metals. Electrophoretic deposition (EPD) offers the feasibility to deposit at room temperature a variety of materials on conductive substrates from colloidal suspensions under electric fields. In this work single layers of chitosan composite coatings containing titania nanoparticles (n-TiO2) were deposit by EPD on electron beam (EB) structured Ti6Al4V titanium alloy. Surface structures were designed following different criteria in order to develop specific topography on the Ti6Al4V substrate. n-TiO2 particles were used as a model particle in order to demonstrate the versatility of the proposed technique for achieving homogenous chitosan based coatings on structured surfaces. A linear relation between EPD time and deposition yield on different patterned Ti6Al4V surfaces was determined under constant voltage conditions, obtaining homogeneous EPD coatings which replicate the 3D structure (pattern) of the substrate surface. The present results show that a combination of both techniques can be considered a promising surface modification approach for metallic implants, which should lead to improved interaction between the implant surface and the biological environment for orthopaedic applications.


2011 ◽  
Vol 43 (12) ◽  
pp. 1543-1548 ◽  
Author(s):  
J. N. Li ◽  
C. Z. Chen ◽  
B. B. Cui ◽  
T. Squartini

Author(s):  
Nan Huang ◽  
Ping Yang ◽  
Yong Xiang Leng ◽  
Jun Ying Chen ◽  
Jin Wang ◽  
...  

Coatings ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 249 ◽  
Author(s):  
Wei Liu ◽  
Shifeng Liu ◽  
Liqiang Wang

With the increasing demand for bone implant therapy, titanium alloy has been widely used in the biomedical field. However, various potential applications of titanium alloy implants are easily hampered by their biological inertia. In fact, the interaction of the implant with tissue is critical to the success of the implant. Thus, the implant surface is modified before implantation frequently, which can not only improve the mechanical properties of the implant, but also polish up bioactivity and osseoconductivity on a cellular level. This paper aims at reviewing titanium surface modification techniques for biomedical applications. Additionally, several other significant aspects are described in detail in this article, for example, micromorphology, microstructure evolution that determines mechanical properties, as well as a number of issues concerning about practical application of biomedical implants.


2019 ◽  
Vol 1393 ◽  
pp. 012142
Author(s):  
A D Teresov ◽  
Yu H Akhmadeev ◽  
Yu F Ivanov ◽  
P V Moskvin ◽  
E A Petrikova ◽  
...  

2003 ◽  
Author(s):  
Mingwei Li ◽  
NeShante Morris ◽  
Steven Mwenifumbo ◽  
Mark S. Keirstead ◽  
Wole Soboyejo

Sign in / Sign up

Export Citation Format

Share Document