Improving Blood Compatibility of Cardiovascular Devices by Surface Modification

2007 ◽  
pp. 801-804
Author(s):  
Nan Huang ◽  
Ping Yang ◽  
Yong Xiang Leng ◽  
Jun Ying Chen ◽  
Jin Wang ◽  
...  
Keyword(s):  
Surface Modification ◽  
Blood Compatibility ◽  
Cardiovascular Devices

Improving Blood Compatibility of Cardiovascular Devices by Surface Modification

2007 ◽  
Vol 342-343 ◽  
pp. 801-804 ◽  
Author(s):  
Nan Huang ◽  
Ping Yang ◽  
Yong Xiang Leng ◽  
Jun Ying Chen ◽  
Jin Wang ◽  
...  
Keyword(s):  
Surface Modification ◽  
Artificial Heart ◽  
Heart Valves ◽  
Blood Compatibility ◽  
Artificial Heart Valve ◽  
Cardiovascular Devices ◽  
Inorganic Films ◽  
Artificial Heart Valves ◽  
Plasma Grafting ◽  
Circulation Tube

This paper presents recent activities on the surface modification of blood contacting biomaterials and devices in the author’s laboratory. Surface coating of inorganic films on materials for artificial heart valves, ventricular pumps and coronary stents, such as titanium, stainless steel and low temperature isotropic pryolitc carbon, etc, shows a significant improvement in the anticoagulation behavior. Further, the formation of functional groups such as hydroxyl or amino groups and the binding of biomolecules as well as seeding of endothelial cell shows the promise of biomimetic surface formation. Plasma grafting on materials for artificial heart valve sewing cuff, extracorporeal circulation tube, etc, such as PET, PU, PVC polymers, revealed a significant improvement of anti-platelet adhesion as well as anti-bacterial properties.

scholarly journals Biomaterials in Cardiovascular Research: Applications and Clinical Implications

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Saravana Kumar Jaganathan ◽  
Eko Supriyanto ◽  
Selvakumar Murugesan ◽  
Arunpandian Balaji ◽  
Manjeesh Kumar Asokan
Keyword(s):  
Surface Modification ◽  
Pluripotent Stem Cells ◽  
Blood Compatibility ◽  
Current Trend ◽  
Basic Research ◽  
Clinical Implications ◽  
Cardiovascular Research ◽  
Cardiovascular Devices ◽  
One Stop ◽  
Cardiac Implants

Cardiovascular biomaterials (CB) dominate the category of biomaterials based on the demand and investments in this field. This review article classifies the CB into three major classes, namely, metals, polymers, and biological materials and collates the information about the CB. Blood compatibility is one of the major criteria which limit the use of biomaterials for cardiovascular application. Several key players are associated with blood compatibility and they are discussed in this paper. To enhance the compatibility of the CB, several surface modification strategies were in use currently. Some recent applications of surface modification technology on the materials for cardiovascular devices were also discussed for better understanding. Finally, the current trend of the CB, endothelization of the cardiac implants and utilization of induced human pluripotent stem cells (ihPSCs), is also presented in this review. The field of CB is growing constantly and many new investigators and researchers are developing interest in this domain. This review will serve as a one stop arrangement to quickly grasp the basic research in the field of CB.

Surface Modification of Copolyether-Urethane Catheters with Poly(Ethylene Oxide)

1989 ◽  
Vol 12 (6) ◽  
pp. 390-394 ◽  
Author(s):  
E. Brinkman ◽  
A. Poot ◽  
T. Beugeling ◽  
L. Van Der Does ◽  
A. Bantjes
Keyword(s):  
Surface Modification ◽  
Ethylene Oxide ◽  
Blood Compatibility ◽  
Angle Measurements ◽  
Fold Reduction ◽  
Contact Angle Measurements ◽  
Platelet Deposition ◽  
Poly Ethylene Oxide ◽  
Poly Ethylene

Pellethane 2363 80A catheters were modified with poly(ethylene oxide) in order to improve their blood compatibility. Contact angle measurements showed that Pellethane 2363 80A surfaces had increased wettability after this modification. The results of in vitro blood compatibility tests showed that surface modification with poly(ethylene oxide) resulted in a five-fold reduction of platelet deposition. Activation of coagulation was not affected.

scholarly journals Covalent surface modification of a titanium alloy with a phosphorylcholine-containing copolymer for reduced thrombogenicity in cardiovascular devices

2009 ◽  
Vol 91A (1) ◽  
pp. 18-28 ◽  
Author(s):  
Sang-Ho Ye ◽  
Carl A. Johnson ◽  
Joshua R. Woolley ◽  
Trevor A. Snyder ◽  
Lara J. Gamble ◽  
...  
Keyword(s):  
Titanium Alloy ◽  
Surface Modification ◽  
Cardiovascular Devices

Facile Surface Modification of Nitinol with Dopamine-Conjugated Hyaluronic Acid for Improving Blood Compatibility

2016 ◽  
Vol 6 (10) ◽  
pp. 780-787 ◽  
Author(s):  
Eugene Lih ◽  
So Yoon Chi ◽  
Tae Il Son ◽  
Yoon Ki Joung ◽  
Dong Keun Han
Keyword(s):  
Surface Modification ◽  
Hyaluronic Acid ◽  
Blood Compatibility

Facile surface modification of glass with zwitterionic polymers for improving the blood compatibility

2018 ◽  
Vol 5 (6) ◽  
pp. 065401 ◽  
Author(s):  
Lingling Zhang ◽  
Xiaojuan Chen ◽  
Pingsheng Liu ◽  
Jing Wang ◽  
Haomiao Zhu ◽  
...  
Keyword(s):  
Surface Modification ◽  
Blood Compatibility ◽  
Zwitterionic Polymers

AFM and Fractal Analysis of Biomaterial Microtopography

1998 ◽  
Vol 4 (S2) ◽  
pp. 926-927
Author(s):  
S. Jo ◽  
T. Li ◽  
K. Park
Keyword(s):  
Surface Modification ◽  
Self Assembly ◽  
Blood Compatibility ◽  
Carbon Chain ◽  
Atomic Force ◽  
Covalent Grafting ◽  
Biomaterial Surfaces ◽  
Poly Ethylene ◽  
Glass Surfaces

Although significant advances have been made in the development of biocompatible materials, currently available biomaterials still present a number of problems for in vivo applications. One of the attempts to improve the biocompatibility, especially blood-compatibility, of biomaterials has been surface modification. Typically, poly(ethylene glycol) (PEG), albumin, heparin, and phospholipid molecules are grafted to the surface to prevent protein adsorption and cell adhesion. We have been modifying biomaterial surfaces by covalent grafting of PEG and albumin. The control and modified surfaces were examined using an atomic force microscope (AFM). In this study, we examined the surface topography changes by surface modification using PEO grafting to glass as a model system.Glass surfaces were modified with PEO using (N-triethoxysilylpropyl)-Omonomethoxy PEG urethane (PEG-Si), a PEG derivative containing a hydrophobic carbon chain and triethoxysilyl group at one end of the PEG chain. The presence of the hydrophobic carbon chain allowed self-assembly on the surface and triethoxysilyl resulted in covalent bonding to glass surfaces

Sign in / Sign up

Export Citation Format

Share Document