scholarly journals In situ forming poly(ethylene glycol)-based hydrogels via thiol-maleimide Michael-type addition

2011 ◽  
Vol 98A (2) ◽  
pp. 201-211 ◽  
Author(s):  
Yao Fu ◽  
Weiyuan John Kao
Keyword(s):  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
In Situ Forming ◽  
Michael Type Addition ◽  
Poly Ethylene

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Copolymers for the Formulation of In Situ Forming Depot Long-Acting Injectables

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 605
Author(s):  
Marie-Emérentienne Cagnon ◽  
Silvio Curia ◽  
Juliette Serindoux ◽  
Jean-Manuel Cros ◽  
Feifei Ng ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Surface Erosion ◽  
Sustained Delivery ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
In Situ Forming ◽  
Poly Ethylene ◽  
Long Acting

This article describes the utilization of (methoxy)poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) ((m)PEG–PTMC) diblock and triblock copolymers for the formulation of in situ forming depot long-acting injectables by solvent exchange. The results shown in this manuscript demonstrate that it is possible to achieve long-term drug deliveries from suspension formulations prepared with these copolymers, with release durations up to several months in vitro. The utilization of copolymers with different PEG and PTMC molecular weights affords to modulate the release profile and duration. A pharmacokinetic study in rats with meloxicam confirmed the feasibility of achieving at least 28 days of sustained delivery by using this technology while showing good local tolerability in the subcutaneous environment. The characterization of the depots at the end of the in vivo study suggests that the rapid phase exchange upon administration and the surface erosion of the resulting depots are driving the delivery kinetics from suspension formulations. Due to the widely accepted utilization of meloxicam as an analgesic drug for animal care, the results shown in this article are of special interest for the development of veterinary products aiming at a very long-term sustained delivery of this therapeutic molecule.

scholarly journals In situ-forming robust chitosan-poly(ethylene glycol) hydrogels prepared by copper-free azide–alkyne click reaction for tissue engineering

2014 ◽  
Vol 2 (2) ◽  
pp. 167-175 ◽  
Author(s):  
Vinh X. Truong ◽  
Matthew P. Ablett ◽  
Hamish T. J. Gilbert ◽  
James Bowen ◽  
Stephen M. Richardson ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Ethylene Glycol ◽  
Click Reaction ◽  
Poly Ethylene Glycol ◽  
In Situ Forming ◽  
Poly Ethylene

In vivo efficacy of an intratumorally injected in situ-forming doxorubicin/poly(ethylene glycol)-b-polycaprolactone diblock copolymer

Biomaterials ◽  
2011 ◽  
Vol 32 (20) ◽  
pp. 4556-4564 ◽  
Author(s):  
Yun Mi Kang ◽  
Gyeong Hae Kim ◽  
Jae Il Kim ◽  
Da Yeon Kim ◽  
Bit Na Lee ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Diblock Copolymer ◽  
Poly Ethylene Glycol ◽  
In Vivo Efficacy ◽  
In Situ Forming ◽  
Poly Ethylene

In vitro and in vivo protein delivery from in situ forming poly(ethylene glycol)–poly(lactide) hydrogels

2007 ◽  
Vol 119 (3) ◽  
pp. 320-327 ◽  
Author(s):  
Christine Hiemstra ◽  
Zhiyuan Zhong ◽  
Sophie R. Van Tomme ◽  
Mies J. van Steenbergen ◽  
John J.L. Jacobs ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Protein Delivery ◽  
Poly Ethylene Glycol ◽  
In Situ Forming ◽  
Poly Ethylene

Preparation and characterization of hydrogels based on acryloyl end-capped four-arm star-shaped poly(ethylene glycol)-branched-oligo(l-lactide) via Michael-type addition reaction

2010 ◽  
Vol 64 (5) ◽  
Author(s):  
Huai-Qing Yu ◽  
Rimin Cong
Keyword(s):  
Ethylene Glycol ◽  
Addition Reaction ◽  
Gelation Time ◽  
Precursor Solution ◽  
Poly Ethylene Glycol ◽  
Biomedical Material ◽  
Michael Type Addition ◽  
Degradation Behaviors ◽  
Poly Ethylene

AbstractAn acryloyl end-capped four-arm star-shaped poly(ethylene glycol)-branched-oligo(l-lactide) (4A-PEG-PLA) macromer was firstly prepared. A novel kind of hydrogels was synthesized via the Michael-type addition reaction between (2S,3S)-1,4-bis-sulfanylbutane-2,3-diol (dithiothreitol) and this macromer. Gelation time was determined visually as the time when the precursor solution did not flow on inverting the vials. Hydrogel structure was characterized by FTIR analysis, swelling and degradation tests. It was found that colorless and transparent hydrogels were quickly generated in situ. The gelation time, swelling and degradation behaviors of this kind of hydrogels could be adjusted by changing the concentration of the macromer solution in PBS buffer (pH 7.4). This novel hydrogel is expected to be used as a biomedical material.

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