Sustained release of human growth hormone from in situ forming hydrogels using self-assembly of fluoroalkyl-ended poly(ethylene glycol)

Biomaterials ◽  
2005 ◽  
Vol 26 (25) ◽  
pp. 5259-5266 ◽  
Author(s):  
Giyoong Tae ◽  
Julia A. Kornfield ◽  
Jeffrey A. Hubbell
Keyword(s):  
Growth Hormone ◽  
Ethylene Glycol ◽  
Sustained Release ◽  
Self Assembly ◽  
Human Growth ◽  
Poly Ethylene Glycol ◽  
In Situ Forming ◽  
Poly Ethylene ◽  
In Situ Forming Hydrogels

Release of human growth hormone from an in-situ implant modulated by poly(ethylene glycol) dimethyl ether and tris(hydroxymethyl) aminomethane

2020 ◽  
Vol 29 (11) ◽  
pp. 1019-1029
Author(s):  
Siyavash Mirzaei ◽  
Hamid Mobedi ◽  
Hamid Gourabi ◽  
Mohammad Hossein Sanati ◽  
Sakine Khezli ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Ethylene Glycol ◽  
Dimethyl Ether ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Poly Ethylene Glycol ◽  
Ethylene Glycol Dimethyl Ether ◽  
Poly Ethylene ◽  
In Situ Implant

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Copolymers for the Formulation of In Situ Forming Depot Long-Acting Injectables

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 605
Author(s):  
Marie-Emérentienne Cagnon ◽  
Silvio Curia ◽  
Juliette Serindoux ◽  
Jean-Manuel Cros ◽  
Feifei Ng ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Surface Erosion ◽  
Sustained Delivery ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
In Situ Forming ◽  
Poly Ethylene ◽  
Long Acting

This article describes the utilization of (methoxy)poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) ((m)PEG–PTMC) diblock and triblock copolymers for the formulation of in situ forming depot long-acting injectables by solvent exchange. The results shown in this manuscript demonstrate that it is possible to achieve long-term drug deliveries from suspension formulations prepared with these copolymers, with release durations up to several months in vitro. The utilization of copolymers with different PEG and PTMC molecular weights affords to modulate the release profile and duration. A pharmacokinetic study in rats with meloxicam confirmed the feasibility of achieving at least 28 days of sustained delivery by using this technology while showing good local tolerability in the subcutaneous environment. The characterization of the depots at the end of the in vivo study suggests that the rapid phase exchange upon administration and the surface erosion of the resulting depots are driving the delivery kinetics from suspension formulations. Due to the widely accepted utilization of meloxicam as an analgesic drug for animal care, the results shown in this article are of special interest for the development of veterinary products aiming at a very long-term sustained delivery of this therapeutic molecule.

scholarly journals In situ-forming robust chitosan-poly(ethylene glycol) hydrogels prepared by copper-free azide–alkyne click reaction for tissue engineering

2014 ◽  
Vol 2 (2) ◽  
pp. 167-175 ◽  
Author(s):  
Vinh X. Truong ◽  
Matthew P. Ablett ◽  
Hamish T. J. Gilbert ◽  
James Bowen ◽  
Stephen M. Richardson ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Ethylene Glycol ◽  
Click Reaction ◽  
Poly Ethylene Glycol ◽  
In Situ Forming ◽  
Poly Ethylene

The in situ formation of nanoparticles via RAFT polymerization-induced self-assembly in a continuous tubular reactor

2017 ◽  
Vol 8 (9) ◽  
pp. 1495-1506 ◽  
Author(s):  
Jinying Peng ◽  
Chun Tian ◽  
Lifen Zhang ◽  
Zhenping Cheng ◽  
Xiulin Zhu
Keyword(s):  
Ethylene Glycol ◽  
Diblock Copolymer ◽  
Self Assembly ◽  
Raft Polymerization ◽  
Tubular Reactor ◽  
Poly Ethylene Glycol ◽  
In Situ Formation ◽  
Poly Ethylene ◽  
Glycol Methyl Ether

Amphiphilic poly(poly(ethylene glycol)methyl ether methacrylate)-b-poly(methyl methacrylate) (PPEGMA-b-PMMA) diblock copolymer nanoparticles were successfully synthesized via polymerization-induced self-assembly (PISA) at 70 °C in a continuous tubular reactor.

The Conformation of the Poly(ethylene glycol) Chain in Mono-PEGylated Lysozyme and Mono-PEGylated Human Growth Hormone

2011 ◽  
Vol 22 (11) ◽  
pp. 2317-2323 ◽  
Author(s):  
Sheetal S. Pai ◽  
Boualem Hammouda ◽  
Kunlun Hong ◽  
Danilo C. Pozzo ◽  
Todd M. Przybycien ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Ethylene Glycol ◽  
Human Growth Hormone ◽  
Human Growth ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

In vivo efficacy of an intratumorally injected in situ-forming doxorubicin/poly(ethylene glycol)-b-polycaprolactone diblock copolymer

Biomaterials ◽  
2011 ◽  
Vol 32 (20) ◽  
pp. 4556-4564 ◽  
Author(s):  
Yun Mi Kang ◽  
Gyeong Hae Kim ◽  
Jae Il Kim ◽  
Da Yeon Kim ◽  
Bit Na Lee ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Diblock Copolymer ◽  
Poly Ethylene Glycol ◽  
In Vivo Efficacy ◽  
In Situ Forming ◽  
Poly Ethylene
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