Pharmacokinetic and pharmacodynamic evaluation of a novel in situ forming poly(ethylene glycol)-based hydrogel for the controlled delivery of the camptothecins

2006 ◽  
Vol 112 (3) ◽  
pp. 333-342 ◽  
Author(s):  
Anita Lalloo ◽  
Piyun Chao ◽  
Peidi Hu ◽  
Stanley Stein ◽  
Patrick J. Sinko
Keyword(s):  
Ethylene Glycol ◽  
Controlled Delivery ◽  
Poly Ethylene Glycol ◽  
In Situ Forming ◽  
Poly Ethylene

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Copolymers for the Formulation of In Situ Forming Depot Long-Acting Injectables

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 605
Author(s):  
Marie-Emérentienne Cagnon ◽  
Silvio Curia ◽  
Juliette Serindoux ◽  
Jean-Manuel Cros ◽  
Feifei Ng ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Surface Erosion ◽  
Sustained Delivery ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
In Situ Forming ◽  
Poly Ethylene ◽  
Long Acting

This article describes the utilization of (methoxy)poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) ((m)PEG–PTMC) diblock and triblock copolymers for the formulation of in situ forming depot long-acting injectables by solvent exchange. The results shown in this manuscript demonstrate that it is possible to achieve long-term drug deliveries from suspension formulations prepared with these copolymers, with release durations up to several months in vitro. The utilization of copolymers with different PEG and PTMC molecular weights affords to modulate the release profile and duration. A pharmacokinetic study in rats with meloxicam confirmed the feasibility of achieving at least 28 days of sustained delivery by using this technology while showing good local tolerability in the subcutaneous environment. The characterization of the depots at the end of the in vivo study suggests that the rapid phase exchange upon administration and the surface erosion of the resulting depots are driving the delivery kinetics from suspension formulations. Due to the widely accepted utilization of meloxicam as an analgesic drug for animal care, the results shown in this article are of special interest for the development of veterinary products aiming at a very long-term sustained delivery of this therapeutic molecule.

scholarly journals In situ-forming robust chitosan-poly(ethylene glycol) hydrogels prepared by copper-free azide–alkyne click reaction for tissue engineering

2014 ◽  
Vol 2 (2) ◽  
pp. 167-175 ◽  
Author(s):  
Vinh X. Truong ◽  
Matthew P. Ablett ◽  
Hamish T. J. Gilbert ◽  
James Bowen ◽  
Stephen M. Richardson ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Ethylene Glycol ◽  
Click Reaction ◽  
Poly Ethylene Glycol ◽  
In Situ Forming ◽  
Poly Ethylene

In vivo efficacy of an intratumorally injected in situ-forming doxorubicin/poly(ethylene glycol)-b-polycaprolactone diblock copolymer

Biomaterials ◽  
2011 ◽  
Vol 32 (20) ◽  
pp. 4556-4564 ◽  
Author(s):  
Yun Mi Kang ◽  
Gyeong Hae Kim ◽  
Jae Il Kim ◽  
Da Yeon Kim ◽  
Bit Na Lee ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Diblock Copolymer ◽  
Poly Ethylene Glycol ◽  
In Vivo Efficacy ◽  
In Situ Forming ◽  
Poly Ethylene

In vitro and in vivo protein delivery from in situ forming poly(ethylene glycol)–poly(lactide) hydrogels

2007 ◽  
Vol 119 (3) ◽  
pp. 320-327 ◽  
Author(s):  
Christine Hiemstra ◽  
Zhiyuan Zhong ◽  
Sophie R. Van Tomme ◽  
Mies J. van Steenbergen ◽  
John J.L. Jacobs ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Protein Delivery ◽  
Poly Ethylene Glycol ◽  
In Situ Forming ◽  
Poly Ethylene
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