Pregnancy‐related change in pQCT and bone biochemistry in a population with a habitually low calcium intake

Introduction: Metabolic abnormalities are common cause of urolithiasis in pediatric age group. Children with urolithiasis are associated with considerable morbidity. By treating these abnormalities stone formation is prevented. Objectives: Prospective study to nd the metabolic risk factors of urolithiasis in children and compare them with literature. Materials and Methods: In open, prospective and observational study, 85 children were evaluated from August 2019 to June 2020. In all patients' dietary history, water intake and results of laboratory ndings were recorded. All urine samples obtained from patients were without dietary restrictions. Reference pediatric 24 hour urinary parameter was used according to western literature. Results: We investigated 85 patients with urolithiasis. Low urine volume was found in 52 patients which is comparable with previous studies indicating simple intervention as to increase water intake. Low calcium intake was found in 48 patients suggesting that low calcium intake is associated with higher incidence of urolithiasis due to increased intestinal oxalate absorption. Hypocalcaemia was found in 34 patients and 24 hour urinary abnormality was found in only 18 patients'. Both these nding does not support previous literature. Stone analysis nding does not correlate with urinary nding. Conclusions: Hypocalcaemia is major metabolic abnormality in contradiction to western literature. Low urine volume secondary to low water intake is predominant nding .There are no nomograms for urinary excretion of Calcium, uric acid, oxalate and citrate in Indian children. Keeping the optimum blood calcium level & increased uid intake can prevent stone formation in children.

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The Effect of Ovariectomy and Low Calcium Intake on Bone.

Orthopedics & Traumatology ◽

10.5035/nishiseisai.40.373 ◽

1991 ◽

Vol 40 (1) ◽

pp. 373-376

Author(s):

Motonori Yamaura ◽

Toshitaka Nakamura ◽

Shin-ichi Mishima ◽

Hiroshi Tsurukami ◽

Azusa Kano

Keyword(s):

Calcium Intake ◽

Low Calcium

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Strontium-calcium interrelationships in the mature rat

American Journal of Physiology-Legacy Content ◽

10.1152/ajplegacy.1960.199.1.94 ◽

1960 ◽

Vol 199 (1) ◽

pp. 94-102 ◽

Cited By ~ 10

Author(s):

Roy C. Thompson ◽

Ray F. Palmer

Keyword(s):

Calcium Intake ◽

Calcium Level ◽

Dietary Calcium ◽

Mature Female ◽

Female Rats ◽

Total Calcium ◽

Calcium Diet ◽

Low Calcium ◽

Extensive Exchange ◽

Metabolic Behavior

The comparative metabolic behavior of strontium and calcium was studied in mature, female rats exposed both chronically and acutely to Sr90 and Ca45, while on diets of various total calcium contents. When orally administered, there is a discrimination against Sr90 relative to Ca45, apparent in the isotope levels in both blood and bone. This discrimination becomes smaller in magnitude as the level of calcium intake is increased. On all levels of calcium intake there is extensive exchange of calcium and strontium between bone and blood. On low-calcium diets the calcium moving from bone to blood is almost completely reutilized; as the level of dietary calcium is increased, this reutilization becomes less efficient and the rate of net removal of calcium from bone increases. In contrast, the rate of net removal of strontium from bone was relatively insensitive to changes in dietary calcium level, and on all diets was similar to the rate of net removal of calcium on the highest calcium diet.

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