Tissue and urokinase plasminogen activators in bone tissue and their regulation by parathyroid hormone

2009 ◽  
Vol 6 (10) ◽  
pp. 1081-1090 ◽  
Author(s):  
Gaetane Leloup ◽  
Chantal Peeters-Joris ◽  
Jean-Marie Delaisse ◽  
Ghislain Opdenakker ◽  
Gilbert Vaes
Keyword(s):  
Parathyroid Hormone ◽  
Bone Tissue ◽  
Plasminogen Activators ◽  
Urokinase Plasminogen Activators

Tissue and urokinase plasminogen activators in the environs of venous and ischaemic leg ulcers

1993 ◽  
Vol 80 (5) ◽  
pp. 596-599 ◽  
Author(s):  
M. C. Stacey ◽  
K. G. Burnand ◽  
M. Mahmoud-Alexandroni ◽  
P. J. Gaffney ◽  
B. S. Bhogal
Keyword(s):  
Plasminogen Activators ◽  
Leg Ulcers ◽  
Urokinase Plasminogen Activators

scholarly journals Direct extraction and assay of bone tissue collagenase and its relation to parathyroid-hormone-induced bone resorption

1986 ◽  
Vol 239 (3) ◽  
pp. 793-796 ◽  
Author(s):  
Y Eeckhout ◽  
J M Delaissé ◽  
G Vaes
Keyword(s):  
Parathyroid Hormone ◽  
Bone Resorption ◽  
Bone Tissue ◽  
Direct Extraction ◽  
Latent Form ◽  
Fetal Mouse ◽  
Quantitative Extraction

A method has been developed for the quantitative extraction of collagenase from as little as one 19-day-fetal-mouse calvarium. About 20-40 munits of collagenase are extracted per mg of tissue, all in a latent form that, after proper activation, shows the typical properties of mammalian collagenase. Culturing the calvaria for 2 days with parathyroid hormone (PTH) increases their procollagenase content up to 3-fold and induces bone resorption. Both PTH effects are prevented by cycloheximide, but not by indomethacin. Calcitonin inhibits resorption without affecting the PTH-induced procollagenase synthesis. The role of this synthesis is discussed in relation to the mechanisms of bone resorption.

scholarly journals CHANGES IN PHOSPHORUS-CALCIUM METABOLISM IN EXPERIMENTAL HYPOTHYROIDISM

2020 ◽  
Vol 17 (34) ◽  
pp. 303-310
Author(s):  
Timur Irekovich GANEEV ◽  
Milyausha Fauzievna KABIROVA ◽  
Renat Ramizovich YUNUSOV ◽  
Marina Vladimirovna GALIULLINA
Keyword(s):  
Parathyroid Hormone ◽  
Blood Serum ◽  
Bone Tissue ◽  
Calcium Metabolism ◽  
Colorimetric Method ◽  
Magnesium Content ◽  
Femoral Diaphysis ◽  
Histological Structure ◽  
Intragastric Administration ◽  
Tnf Α

The aim of this work was to study changes in the state of phosphorus-calcium metabolism, indicators of certain hormones, cytokine profile, and histological structure of bone tissue in experimental hypothyroidism in rats. Experimental hypothyroidism was caused by daily intragastric administration of Thiamazole in a dose of 2.5 mg / 100 g body weight for 21 days. The colorimetric method was used to determine blood serum calcium, phosphorus, and magnesium content. Bone metabolism markers, thyrotropin level, total T3 and T4, testosterone, follicle-stimulating (FSH) and luteinizing (LH) hormones, parathyroid hormone (PTH), interleukin-1β (IL-1β) and -6 (IL-6), necrosis factor tumors-alpha (TNF-α) were studied using an enzyme immunoassay. To determine the histological structure of bone tissue, prepared sections of the femoral diaphysis were studied under a microscope of the MZ-300 series (Austria). It was found that hypothyroidism development is confirmed by decreased content of thyroxine and triiodothyronine on the background of the increased secretion of thyroidstimulating hormone. Experimental hypothyroidism is accompanied by a decrease in the concentration of bone alkaline phosphatase in the blood serum while maintaining the collagen C-terminal telopeptides type 1, reflecting impaired remodeling processes, there is also a decrease in testosterone secretion, an increase in gonadotropins, parathyroid hormone, pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α). Signs characteristic for the developing dysplastic osteoporosis are histologically revealed in the diaphysis of the tubular bones.

scholarly journals Possible evidence of pregnancy and or famine in an ancient nubian female

2005 ◽  
Vol 80 (1) ◽  
Author(s):  
John Denton ◽  
Jennifer Mann ◽  
Ann Rosalie David
Keyword(s):  
Parathyroid Hormone ◽  
Bone Resorption ◽  
Physical Exercise ◽  
Bone Tissue ◽  
Calcium Intake ◽  
Nutritional Quality ◽  
Bone Cells ◽  
Mechanical Stresses ◽  
Bone Apposition ◽  
Blood Calcium

A female Nubian femur from the Manchester Mummy Collection exhibits periodic features of bone resorption, bone apposition and then bone resorption as demonstrated by bone histology. Bone is a metabolically active, dynamic, structural tissue whose development and maintenance is influenced by many factors, including nutrition, sunlight, hormonal secretions, and physical exercise. When biochemical or mechanical stresses occur bone cells respond either producing or resorbing bone. When food becomes scarce or of poor nutritional quality, for example in times of famine or flood, malnutrition and concurrent low calcium intake occur. In low blood calcium conditions, parathyroid hormone is released. This stimulates osteoclasts to break down bone tissue. When nutritional state normalises, bone is laid down again and this cycle recurs. Additionally, during pregnancy there is profound resorbtion of the maternal skeleton in order that the foetus may thrive. The condition of the observed bone is consistent with such cyclic events.

Inhibitory Effect of Amiloride on the Urokinase Plasminogen Activators in Prostatic Cancer

Tumor Biology ◽  
1998 ◽  
Vol 19 (1) ◽  
pp. 60-64 ◽  
Author(s):  
Paul Ray ◽  
Rashid Bhatti ◽  
John Gadarowski ◽  
Nancy Bell ◽  
Shahida Nasruddin
Keyword(s):  
Prostatic Cancer ◽  
Plasminogen Activators ◽  
Inhibitory Effect ◽  
Urokinase Plasminogen Activators
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