scholarly journals Correlates of trabecular and cortical volumetric bone mineral density of the radius and tibia in older men: The osteoporotic fractures in men study

2010 ◽  
Vol 25 (5) ◽  
pp. 1017-1028 ◽  
Author(s):  
Kamil E Barbour ◽  
Joseph M Zmuda ◽  
Elsa S Strotmeyer ◽  
Mara J Horwitz ◽  
Robert Boudreau ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Osteoporotic Fractures ◽  
Older Men ◽  
Volumetric Bone Mineral Density ◽  
Mineral Density

scholarly journals A 6-Year Follow-Up of Fracture Incidence and Volumetric Bone Mineral Density Development in Girls With Turner Syndrome

2017 ◽  
Vol 103 (3) ◽  
pp. 1188-1197 ◽  
Author(s):  
Ondrej Soucek ◽  
Eckhard Schönau ◽  
Jan Lebl ◽  
Johannes Willnecker ◽  
Zdenek Hlavka ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Turner Syndrome ◽  
Bone Strength ◽  
Bone Mineral ◽  
Osteoporotic Fractures ◽  
Volumetric Bone Mineral Density ◽  
Fracture Rate ◽  
Mineral Density ◽  
Bone Parameters ◽  
Normal Bone

Abstract Context Patients with Turner syndrome (TS) are at risk for osteoporotic fractures. Objective The aims of this study were to assess the incidence of clinically important fractures in girls with TS and prospectively describe the development of volumetric bone mineral density (BMD). Design Peripheral quantitative computerized tomography (pQCT) of the radius every other year over the 6 years of observation. Setting Government-funded university referral center. Participants Thirty-two girls with TS, aged 6 to 16 years, were included in the analyses. Fracture incidence was compared with the data in the general population. Bone density and strength were compared with data from 185 healthy girls. Outcomes The main clinical outcome was the fracture occurrence. The secondary outcomes were the changes in Z-scores of the bone parameters. Results Three girls with TS sustained four fractures during 6 years of observation. The fracture rate in TS was not substantially higher than the downward-biased fracture-rate estimate from age-matched, healthy controls (P = 0.48). Whereas the trabecular BMD Z-score decreased with age (β estimate −0.21 ± 0.04, P < 0.001), total bone cross-sectional area correspondingly increased (+0.16 ± 0.04, P < 0.001), which led to normal bone strength. A positive history of incident fractures was not significantly associated with any of the pQCT-derived bone parameters. Conclusions Current pediatric TS patients that are treated with growth hormone and estrogens are not at risk for osteoporotic fractures. Low BMD in TS may be counterweighted by enlarged bone radius, which leads to normal bone strength at the appendicular skeleton.

scholarly journals Diagnostic accuracy of quantitative dual-energy CT-based volumetric bone mineral density assessment for the prediction of osteoporosis-associated fractures

2021 ◽  
Author(s):  
Leon D. Gruenewald ◽  
Vitali Koch ◽  
Simon S. Martin ◽  
Ibrahim Yel ◽  
Katrin Eichler ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
At Risk ◽  
Bone Mineral ◽  
Osteoporotic Fractures ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Volumetric Bone Mineral Density ◽  
Material Decomposition ◽  
Mineral Density ◽  
Risk Patients

Abstract Objectives To evaluate the predictive value of volumetric bone mineral density (BMD) assessment of the lumbar spine derived from phantomless dual-energy CT (DECT)-based volumetric material decomposition as an indicator for the 2-year occurrence risk of osteoporosis-associated fractures. Methods L1 of 92 patients (46 men, 46 women; mean age, 64 years, range, 19–103 years) who had undergone third-generation dual-source DECT between 01/2016 and 12/2018 was retrospectively analyzed. For phantomless BMD assessment, dedicated DECT postprocessing software using material decomposition was applied. Digital files of all patients were sighted for 2 years following DECT to obtain the incidence of osteoporotic fractures. Receiver operating characteristic (ROC) analysis was used to calculate cut-off values and logistic regression models were used to determine associations of BMD, sex, and age with the occurrence of osteoporotic fractures. Results A DECT-derived BMD cut-off of 93.70 mg/cm3 yielded 85.45% sensitivity and 89.19% specificity for the prediction to sustain one or more osteoporosis-associated fractures within 2 years after BMD measurement. DECT-derived BMD was significantly associated with the occurrence of new fractures (odds ratio of 0.8710, 95% CI, 0.091–0.9375, p < .001), indicating a protective effect of increased DECT-derived BMD values. Overall AUC was 0.9373 (CI, 0.867–0.977, p < .001) for the differentiation of patients who sustained osteoporosis-associated fractures within 2 years of BMD assessment. Conclusions Retrospective DECT-based volumetric BMD assessment can accurately predict the 2-year risk to sustain an osteoporosis-associated fracture in at-risk patients without requiring a calibration phantom. Lower DECT-based BMD values are strongly associated with an increased risk to sustain fragility fractures. Key Points •Dual-energy CT–derived assessment of bone mineral density can identify patients at risk to sustain osteoporosis-associated fractures with a sensitivity of 85.45% and a specificity of 89.19%. •The DECT-derived BMD threshold for identification of at-risk patients lies above the American College of Radiology (ACR) QCT guidelines for the identification of osteoporosis (93.70 mg/cm3 vs 80 mg/cm3).

Comparison of areal and estimated volumetric bone mineral density values between older men and women

1995 ◽  
Vol 5 (4) ◽  
pp. 271-275 ◽  
Author(s):  
R. A. Faulkner ◽  
R. G. McCulloch ◽  
S. L. Fyke ◽  
W. E. De Coteau ◽  
H. A. McKay ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Older Men ◽  
Volumetric Bone Mineral Density ◽  
Mineral Density ◽  
Men And Women ◽  
Density Values ◽  
Older Men And Women

scholarly journals Candidate gene analysis of femoral neck trabecular and cortical volumetric bone mineral density in older men

2009 ◽  
Vol 25 (2) ◽  
pp. 330-338 ◽  
Author(s):  
Laura M Yerges ◽  
Lambertus Klei ◽  
Jane A Cauley ◽  
Kathryn Roeder ◽  
Candace M Kammerer ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Femoral Neck ◽  
Candidate Gene ◽  
Bone Mineral ◽  
Older Men ◽  
Gene Analysis ◽  
Volumetric Bone Mineral Density ◽  
Mineral Density ◽  
Candidate Gene Analysis

scholarly journals Correlates of T50 and relationships with bone mineral density in community-living older men: the osteoporotic fractures in men (MrOS) study

2019 ◽  
Vol 30 (7) ◽  
pp. 1529-1531
Author(s):  
A. L. Bullen ◽  
C. A. M. Anderson ◽  
E. R. Hooker ◽  
D. M. Kado ◽  
E. Orwoll ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Osteoporotic Fractures ◽  
Older Men ◽  
Community Living ◽  
Mineral Density

The association of sex hormone levels with quantitative ultrasound, bone mineral density, bone turnover and osteoporotic fractures in older men and women

2007 ◽  
Vol 67 (2) ◽  
pp. 295-303 ◽  
Author(s):  
Natalia O. Kuchuk ◽  
Natasja M. van Schoor ◽  
Saskia M. F. Pluijm ◽  
Johannes H. Smit ◽  
Willem de Ronde ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Quantitative Ultrasound ◽  
Osteoporotic Fractures ◽  
Older Men ◽  
Mineral Density ◽  
Men And Women ◽  
Older Men And Women ◽  
Ultrasound Bone

scholarly journals Areal and volumetric bone mineral density and risk of multiple types of fracture in older men

Bone ◽  
2016 ◽  
Vol 92 ◽  
pp. 100-106 ◽  
Author(s):  
Didier Chalhoub ◽  
Eric S. Orwoll ◽  
Peggy M. Cawthon ◽  
Kristine E. Ensrud ◽  
Robert Boudreau ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Older Men ◽  
Volumetric Bone Mineral Density ◽  
Mineral Density
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