Role of AKT/PKB signaling in fibroblast growth factor-1 (FGF-1)-induced angiogenesis in the chicken chorioallantoic membrane (CAM)

2004 ◽  
Vol 94 (1) ◽  
pp. 109-116 ◽  
Author(s):  
Reza Forough ◽  
Brian Weylie ◽  
Chirag Patel ◽  
Sandy Ambrus ◽  
Ugra S. Singh ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Chorioallantoic Membrane ◽  
Fibroblast Growth ◽  
Chicken Chorioallantoic Membrane

scholarly journals FGF-2 binding to fibrin(ogen) is required for augmented angiogenesis

Blood ◽  
2006 ◽  
Vol 107 (1) ◽  
pp. 126-131 ◽  
Author(s):  
Abha Sahni ◽  
Alok A. Khorana ◽  
Raymond B. Baggs ◽  
Hu Peng ◽  
Charles W. Francis
Keyword(s):  
Endothelial Cell ◽  
Growth Factor ◽  
Binding Site ◽  
Fibroblast Growth Factor ◽  
Chorioallantoic Membrane ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Wild Type ◽  
Chicken Chorioallantoic Membrane ◽  
Stimulation Of

Abstract We have shown previously that fibrin(ogen) binds fibroblast growth factor 2 (FGF-2) and potentiates stimulation of endothelial-cell (EC) proliferation. We have now used 2 FGF-2 mutants differing only in the 5 residues constituting the binding site to characterize the importance of this interaction in angiogenesis. The nonbinding (2212) and binding (221*2) mutants stimulated EC proliferation by 2.2 ± 0.4-fold and 2.9 ± 0.3-fold over control, respectively, and both were similar to wild-type (wt) FGF-2 (2.5 ± 0.3-fold). Proliferation was augmented by fibrinogen to 5.3 ± 1.2-fold and 4.8 ± 0.8-fold with wtFGF-2 and 221*2, whereas no augmentation occurred with 2212 and fibrinogen. Using a placental explant model in a fibrin matrix, wtFGF-2 resulted in 2.6 ± 0.9-fold more growth over control, and 221*2 increased growth 3.3 plus or minus 0.9-fold. Vessel outgrowth with 2212 was minimal and comparable to control. Similarly, fibrinogen potentiated wtFGF-2 or 221*2-mediated angiogenesis in the chicken chorioallantoic membrane model. In a mouse Matrigel implant model, fibrinogen significantly increased angiogenesis with either wtFGF-2 or 221*2, whereas there was no augmentation with 2212. These results demonstrate that binding of FGF-2 to fibrin(ogen) mediated by the 5-residue FGF-2-fibrin(ogen) interactive site is required for augmented angiogenesis.

The role of fibroblast growth factor-23 in left atrial volume

2013 ◽  
Vol 165 (5) ◽  
pp. e21 ◽  
Author(s):  
Supawat Ratanapo ◽  
Wonngarm Kittanamongkolchai ◽  
Narat Srivali ◽  
Saeed Ahmed ◽  
Wisit Cheungpasitporn ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Left Atrial ◽  
Fibroblast Growth Factor 23 ◽  
Left Atrial Volume ◽  
Fibroblast Growth ◽  
Atrial Volume

The role of fibroblast growth factor 2 in drug addiction

2018 ◽  
Vol 50 (3) ◽  
pp. 2552-2561 ◽  
Author(s):  
Oren Even‐Chen ◽  
Segev Barak
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Drug Addiction ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth
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