Regulation of DNA repair gene expression in human cancer cell lines

2006 ◽  
Vol 97 (5) ◽  
pp. 1121-1136 ◽  
Author(s):  
Claire J. McGurk ◽  
Michele Cummings ◽  
Beate Köberle ◽  
John A. Hartley ◽  
R. Timothy Oliver ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Repair ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Repair Gene ◽  
Human Cancer Cell Lines ◽  
Dna Repair Gene

Do wine polyphenols modulate p53 gene expression in human cancer cell lines?

2001 ◽  
Vol 34 (5) ◽  
pp. 415-420 ◽  
Author(s):  
George J Soleas ◽  
David M Goldberg ◽  
Linda Grass ◽  
Michael Levesque ◽  
Eleftherios P Diamandis
Keyword(s):  
Gene Expression ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
P53 Gene ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Wine Polyphenols

scholarly journals P11.20 Assessing TTFields-response and associated gene expression in various human cancer cell lines

2019 ◽  
Vol 21 (Supplement_3) ◽  
pp. iii46-iii47
Author(s):  
A Kinzel ◽  
G Lavy-Shahaf ◽  
M Giladi ◽  
R Schneiderman ◽  
K Gotlib ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Synergistic Effects ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Optimal Frequency ◽  
Human Cancer Cell Lines ◽  
Cell Counts

Abstract BACKGROUND Various cancer cell lines were reported to be affected in an inhibitory manner of varying magnitude by tumor treating fields (TTFields). Here, we aimed to detect response markers for TTFields treatment by analyzing specific properties of cell lines according to their response pattern to these alternating electric fields of intermediate frequency and low intensity. MATERIAL AND METHODS We treated 45 cell lines of diverse types of human cancer with TTFields at their specific optimal frequency and equal nominal intensity of 1.7 V/cm for 72 h. In addition to investigating cytotoxicity and clonogenic potential, we used the Cancer Cell Line Encyclopedia (CCLE) database for further analysis: First, to functionally examine patterns of differentially expressed genes or mutations associated with response to TTFields; and second, to compare sensitivity to TTFields using pharmacological profiling (CCLE). RESULTS TTFields had a cytotoxic effect on tested cell lines of 50 % on average (range: 14–86% reduced cell counts), whereas the clonogenic effect varied between no effect and 88 % reduction in the number of colonies. With regard to differential gene expression and mutation analysis, our analysis detected upregulated pathways associated with migration, DNA damage repair response, oxidative stress, and hypoxia. Further, cells identified as having a better response to TTFields were also more sensitive to lapatinib, PHA-665752 and PLX-4720. CONCLUSION In this study, we determined the optimal frequency for maximum response to TTFields in numerous human cancer cell lines. Our results argue strongly for a vast effectiveness of TTFields treatment in cancer cells, and synergistic effects in combination with other therapeutic agents might be revealed in future studies using pharmacological profiling. Beyond that, further research is needed on the role of identified response-associated mutations.

scholarly journals Red pigment produced by Zooshikella ganghwensis inhibited the growth of human cancer cell lines and MMP-1 gene expression

2016 ◽  
Vol 59 (4) ◽  
pp. 567-571 ◽  
Author(s):  
Eun-Ji Oh ◽  
Jung-Hwa Kwon ◽  
Su-Yeon Kim ◽  
Seo-Ji In ◽  
Dong-Geol Lee ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Red Pigment ◽  
Human Cancer Cell Lines

scholarly journals Regulation of laminin β2 chain gene expression in human cancer cell lines

2001 ◽  
Vol 268 (13) ◽  
pp. 3797-3806 ◽  
Author(s):  
Marian E. Durkin ◽  
Finn C. Nielsen ◽  
Frosty Loechel ◽  
Reidar Albrechtsen ◽  
Ulla M. Wewer
Keyword(s):  
Gene Expression ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Chain Gene ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Laminin Β2

scholarly journals Gene Expression Signature of Human Cancer Cell Lines Treated with the Ras Inhibitor Salirasib (S-Farnesylthiosalicylic Acid)

2007 ◽  
Vol 67 (7) ◽  
pp. 3320-3328 ◽  
Author(s):  
Roy Blum ◽  
Ran Elkon ◽  
Shira Yaari ◽  
Adi Zundelevich ◽  
Jasmine Jacob-Hirsch ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Gene Expression Signature ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Expression Signature

scholarly journals Effects of Global O-GlcNAcylation on Galectin Gene-expression Profiles in Human Cancer Cell Lines

2018 ◽  
Vol 38 (12) ◽  
pp. 6691-6697 ◽  
Author(s):  
ALI A. SHERAZI ◽  
KOMAL A. JARIWALA ◽  
AMANDA N. CYBULSKI ◽  
JUSTIN W. LEWIS ◽  
JIM KARAGIANNIS ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines

scholarly journals Systematic variation in gene expression patterns in human cancer cell lines

10.1038/73432 ◽  
2000 ◽  
Vol 24 (3) ◽  
pp. 227-235 ◽  
Author(s):  
Douglas T. Ross ◽  
Uwe Scherf ◽  
Michael B. Eisen ◽  
Charles M. Perou ◽  
Christian Rees ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Expression Patterns ◽  
Cancer Cell Lines ◽  
Systematic Variation ◽  
Gene Expression Patterns ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines
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