Aggregation of Ribosomal Protein S6 at Nucleolus Is Cell Cycle-Controlled and Its Function in Pre-rRNA Processing Is Phosphorylation Dependent

2015 ◽  
Vol 117 (7) ◽  
pp. 1649-1657 ◽  
Author(s):  
Duo Zhang ◽  
Hui-Peng Chen ◽  
Hai-Feng Duan ◽  
Li-Hua Gao ◽  
Yong Shao ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Ribosomal Protein ◽  
Rrna Processing ◽  
Ribosomal Protein S6

scholarly journals Ribosomal Protein S6 Gene Haploinsufficiency Is Associated with Activation of a p53-Dependent Checkpoint during Gastrulation

2006 ◽  
Vol 26 (23) ◽  
pp. 8880-8891 ◽  
Author(s):  
Linda Panić ◽  
Sanda Tamarut ◽  
Melanie Sticker-Jantscheff ◽  
Martina Barkić ◽  
Davor Solter ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Embryonic Development ◽  
Ribosomal Protein ◽  
Ribosome Biogenesis ◽  
Fetal Liver ◽  
Genetic Inactivation ◽  
Developmental Program ◽  
Ribosomal Protein S6 ◽  
M Phase ◽  
Insight Into

ABSTRACT Nascent ribosome biogenesis is required during cell growth. To gain insight into the importance of this process during mouse oogenesis and embryonic development, we deleted one allele of the ribosomal protein S6 gene in growing oocytes and generated S6-heterozygous embryos. Oogenesis and embryonic development until embryonic day 5.5 (E5.5) were normal. However, inhibition of entry into M phase of the cell cycle and apoptosis became evident post-E5.5 and led to perigastrulation lethality. Genetic inactivation of p53 bypassed this checkpoint and prolonged development until E12.5, when the embryos died, showing decreased expression of D-type cyclins, diminished fetal liver erythropoiesis, and placental defects. Thus, a p53-dependent checkpoint is activated during gastrulation in response to ribosome insufficiency to prevent improper execution of the developmental program.

Phosphorylation of nuclear and cytoplasmic pools of ribosomal protein S6 during cell cycle progression

Amino Acids ◽  
2012 ◽  
Vol 44 (4) ◽  
pp. 1233-1240 ◽  
Author(s):  
Margit Rosner ◽  
Katharina Schipany ◽  
Markus Hengstschläger
Keyword(s):  
Cell Cycle ◽  
Ribosomal Protein ◽  
Cell Cycle Progression ◽  
Cycle Progression ◽  
Ribosomal Protein S6
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