Interference with SMO increases chemotherapy drug sensitivity of A2780/DDP cells by inhibiting the Hh/Gli signaling pathway

2020 ◽  
Vol 121 (5-6) ◽  
pp. 3256-3265 ◽  
Author(s):  
Shihong Ma ◽  
Dan Liu ◽  
Wenhua Tan ◽  
Botao Du ◽  
Wei Liu ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Drug Sensitivity ◽  
Chemotherapy Drug

Correlation of genomic analysis by MyAML with chemotherapy drug sensitivity.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 7080-7080
Author(s):  
Pamela S. Becker ◽  
Michael W. Schmitt ◽  
Lawrence A. Loeb ◽  
Weiyi Gu ◽  
Qi Wei ◽  
...  
Keyword(s):  
Drug Sensitivity ◽  
Genomic Analysis ◽  
Chemotherapy Drug

scholarly journals Niclosamide Inhibits Cell Growth and Enhances Drug Sensitivity of Hepatocellular Carcinoma Cells via STAT3 Signaling Pathway

2018 ◽  
Vol 9 (22) ◽  
pp. 4150-4155 ◽  
Author(s):  
Chengzhi Wang ◽  
Xiaoqing Zhou ◽  
Hongjuan Xu ◽  
Xiaqing Shi ◽  
Jinfeng Zhao ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Growth ◽  
Signaling Pathway ◽  
Drug Sensitivity ◽  
Carcinoma Cells ◽  
Hepatocellular Carcinoma Cells ◽  
Stat3 Signaling ◽  
Stat3 Signaling Pathway

scholarly journals Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathway

Oncotarget ◽  
2016 ◽  
Vol 7 (31) ◽  
pp. 50117-50130 ◽  
Author(s):  
Na-Na Tao ◽  
Hong-Zhong Zhou ◽  
Hua Tang ◽  
Xue-Fei Cai ◽  
Wen-Lu Zhang ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Drug Sensitivity ◽  
Hepatoma Cells ◽  
Human Hepatoma ◽  
Glutathione S Transferase ◽  
Sirtuin 3 ◽  
Human Hepatoma Cells ◽  
Jnk Signaling ◽  
Jnk Signaling Pathway

scholarly journals Galectin-1 knockdown improves drug sensitivity of breast cancer by reducing P-glycoprotein expression through inhibiting the Raf-1/AP-1 signaling pathway

Oncotarget ◽  
2017 ◽  
Vol 8 (15) ◽  
pp. 25097-25106 ◽  
Author(s):  
Fang Wang ◽  
Pengwei Lv ◽  
Yuanting Gu ◽  
Lin Li ◽  
Xin Ge ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Signaling Pathway ◽  
Drug Sensitivity ◽  
P Glycoprotein

scholarly journals MiR-450a-5p strengthens the drug sensitivity of gefitinib in glioma chemotherapy via regulating autophagy by targeting EGFR

Oncogene ◽  
2020 ◽  
Vol 39 (39) ◽  
pp. 6190-6202 ◽  
Author(s):  
Yu Liu ◽  
Liang Yang ◽  
Fan Liao ◽  
Wei Wang ◽  
Zhi-Fei Wang
Keyword(s):  
Signaling Pathway ◽  
Drug Sensitivity ◽  
Kinase Inhibitor ◽  
Glioma Cells ◽  
Mtor Signaling ◽  
Migration And Invasion ◽  
Mtor Signaling Pathway ◽  
Glioma Growth

Abstract Glioma reported to be refractory to EGFR tyrosine kinase inhibitor is the most common malignant tumor in central nervous system. Our research showed the low expression of miR-450a-5p and high expression of EGFR in glioma tissues. MiR-450a-5p was also observed to synergize with gefitinib to inhibit the proliferation, migration and invasion and induce the apoptosis and autophagy of glioma cells. Furthermore, miR-450a-5p was demonstrated to target 3′UTR of EGFR, and regulated EGFR-induced PI3K/AKT/mTOR signaling pathway. Moreover, the above effects induced by miR-450a-5p in glioma cells were reversed by WIPI1 silencing. The inhibition role of miR-450a-5p on glioma growth was also confirmed in vivo by subcutaneous and intracranial tumor xenografts. Therefore, we conclude that miR-450a-5p synergizes with gefitinib to inhibit the glioma tumorigenesis through inducing autophagy by regulating the EGFR-induced PI3K/AKT/mTOR signaling pathway, thereby enhancing the drug sensitivity of gefitinib.

The clinical significance of the detection of chemotherapy drug sensitivity in patients with osteosarcoma and soft tissue sarcoma.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e23505-e23505
Author(s):  
Qianrong Wang ◽  
Xiaowen Wang ◽  
Lei Wen ◽  
Jing Zhang ◽  
Jingyue Yang ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Clinical Significance ◽  
Drug Sensitivity ◽  
Chemotherapy Drug
Sign in / Sign up

Export Citation Format

Share Document