Activation of Bombyx mori neuropeptide G protein–coupled receptor A19 by neuropeptide RYamides couples to G q protein‐dependent signaling pathways

2021 ◽  
Author(s):  
Zhiqiang Guo ◽  
Xiaobai He ◽  
Chaohui Jiang ◽  
Ying Shi ◽  
Naiming Zhou
Keyword(s):  
Signaling Pathways ◽  
Bombyx Mori ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Q Protein ◽  
G Protein Coupled

Eleutheroside E Enhances the Long-Term Memory of Radiation-Damaged C. elegans through G-Protein-Coupled Receptor and Neuropeptide Signaling Pathways

2020 ◽  
Vol 83 (11) ◽  
pp. 3315-3323
Author(s):  
Mengyao Liu ◽  
Yi Xiong ◽  
Shan Shan ◽  
Yuanbing Zhu ◽  
Deyong Zeng ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
G Protein ◽  
Long Term Memory ◽  
G Protein Coupled Receptor ◽  
Term Memory ◽  
C Elegans ◽  
Eleutheroside E ◽  
G Protein Coupled

scholarly journals Pigment Dispersing Factor Regulates Ecdysone Biosynthesis via Bombyx Neuropeptide G Protein Coupled Receptor-B2 in the Prothoracic Glands of Bombyx mori

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e103239 ◽  
Author(s):  
Masatoshi Iga ◽  
Takayoshi Nakaoka ◽  
Yutaka Suzuki ◽  
Hiroshi Kataoka
Keyword(s):  
Bombyx Mori ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Pigment Dispersing Factor ◽  
Prothoracic Glands ◽  
G Protein Coupled

FXPRL-amide peptides induce ecdysteroidogenesis through a G-protein coupled receptor expressed in the prothoracic gland of Bombyx mori

2007 ◽  
Vol 273 (1-2) ◽  
pp. 51-58 ◽  
Author(s):  
Ken Watanabe ◽  
J. Joe Hull ◽  
Teruyuki Niimi ◽  
Kunio Imai ◽  
Shogo Matsumoto ◽  
...  
Keyword(s):  
Bombyx Mori ◽  
G Protein ◽  
Prothoracic Gland ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals Diversity of G Protein-Coupled Receptor Signaling Pathways to ERK/MAP Kinase

Neurosignals ◽  
2002 ◽  
Vol 11 (1) ◽  
pp. 34-44 ◽  
Author(s):  
Mariana M. Belcheva ◽  
Carmine J. Coscia
Keyword(s):  
Map Kinase ◽  
Signaling Pathways ◽  
G Protein ◽  
Receptor Signaling ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

scholarly journals A G Protein-biased Designer G Protein-coupled Receptor Useful for Studying the Physiological Relevance of Gq/11-dependent Signaling Pathways

2016 ◽  
Vol 291 (15) ◽  
pp. 7809-7820 ◽  
Author(s):  
Jianxin Hu ◽  
Matthew Stern ◽  
Luis E. Gimenez ◽  
Lizzy Wanka ◽  
Lu Zhu ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Physiological Relevance ◽  
G Protein Coupled

scholarly journals Activation of Intracellular Signaling Pathways by the Murine Cytomegalovirus G Protein-Coupled Receptor M33 Occurs via PLC-β/PKC-Dependent and -Independent Mechanisms

2009 ◽  
Vol 83 (16) ◽  
pp. 8141-8152 ◽  
Author(s):  
Joseph D. Sherrill ◽  
Melissa P. Stropes ◽  
Olivia D. Schneider ◽  
Diana E. Koch ◽  
Fabiola M. Bittencourt ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Protein Kinase ◽  
Signaling Pathways ◽  
G Protein ◽  
Intracellular Signaling ◽  
Murine Cytomegalovirus ◽  
Dependent Manner ◽  
G Protein Coupled Receptor ◽  
G Protein Coupled

ABSTRACT The presence of numerous G protein-coupled receptor (GPCR) homologs within the herpesvirus genomes suggests an essential role for these genes in viral replication in the infected host. Such is the case for murine cytomegalovirus (MCMV), where deletion of the M33 GPCR or replacement of M33 with a signaling defective mutant has been shown to severely attenuate replication in vivo. In the present study we utilized a genetically altered version of M33 (termed R131A) in combination with pharmacological inhibitors to further characterize the mechanisms by which M33 activates downstream signaling pathways. This R131A mutant of M33 fails to support salivary gland replication in vivo and, as such, is an important tool that can be used to examine the signaling activities of M33. We show that M33 stimulates the transcription factor CREB via heterotrimeric Gq/11 proteins and not through promiscuous coupling of M33 to the Gs pathway. Using inhibitors of signaling molecules downstream of Gq/11, we demonstrate that M33 stimulates CREB transcriptional activity in a phospholipase C-β and protein kinase C (PKC)-dependent manner. Finally, utilizing wild-type and R131A versions of M33, we show that M33-mediated activation of other signaling nodes, including the mitogen-activated protein kinase family member p38α and transcription factor NF-κB, occurs in the absence of Gq/11 and PKC signaling. The results from the present study indicate that M33 utilizes multiple mechanisms to modulate intracellular signaling cascades and suggest that signaling through PLC-β and PKC plays a central role in MCMV pathogenesis in vivo.

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