Three-component One-pot Synthetic Route to FunctionalizedN-Phenyl- andN,N-(1,4-phenylene)-2-alkylimino-2,3-dihydrothiazoles under Mild, Solvent- and Catalyst-free Conditions
A metal- and catalyst-free photoinduced radical
cascade hydroalkylation of 1,7-enynes has been
disclosed. The process is triggered by a SET event involving a photoexcited
electron-donor-aceptor complex between NHPI ester and Hantzsch ester, which
decomposes to afford a tertiary radical that is readily trapped by the enyne. <a>The method provides an operationally simple, robust and
step-economical approach to the construction of diversely functionalized
dihydroquinolinones bearing quaternary-centers. A sequential one-pot hydroalkylation-isomerization
approach is also allowed giving access
to a family of quinolinones. A wide substrate scope and high functional group tolerance was observed in both approaches</a>.
Abstract::
An efficient method has been developed for the synthesis of new pyrano[3,2-c] and pyrano[3,2-a]carbazole de-rivatives via a three component reaction of 4-hydroxycarbazole or 2-hydroxycarbazole, isocyanides, and dialkylacetylenedi-carboxylates. Noteworthy features of this protocol include mild reaction conditions, catalyst-free, high atom-economy and high yields.
A general and practical strategy for the construction of various keto-substituted isoxazolidines via one-pot three-component reaction of easily accessible, safer and more stable sulfoxonium ylides, nitrosoarenes and olefins is described.
In this work, a green synthetic route was used to create a number of surface passivated fluorescent carbon quantum dots, which are explored as promising sensing probes, via facile one-pot hydrothermal methods.
A high-yielding cyclocondensation of 4-hydroxycoumarin, phenylglyoxal monohydrate, and heteroarylamines proceeds without catalysis, which gives novel functionalized furo[3,2-c]coumarins and heteroarylamino alkylation of coumarin products in acetonitrile under reflux, is reported for the first time. This tandem process involves sequentially an aldol condensation, Michael addition, a ring closure, and dehydration reaction.
