The Influencing Mechanism of Acidity on the Oxidation Peak Currents of Uric Acid and Ascorbic Acid at the PACPE by Cyclic Voltammetry

Polypyrrole (PPy) fibre electrodes and their ability to sense paracetamol (as a model drug) in addition to interferents such as ascorbic acid and dopamine were studied. PPy was electrodeposited onto carbon fibre (CF) through electropolymerisation using cyclic voltammetry in the presence of two different counter anions: potassium nitrate (KNO3) and sodium dodecyl sulfate (SDS). PPy with SDS as dopant could sense paracetamol with an oxidation peak at 0.55 V vs. Ag/AgCl. The limit of detection of this fibre sensor was found to be 1 µM with a linear range of 1–100 µM of paracetamol (R2 = 0.985).

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The influencing mechanism of acidity on the oxidation peak currents of guanine and uric acid: hydrogen bond catalysis and degree of auxiliary electrode reduction reaction

Electrochimica Acta ◽

10.1016/j.electacta.2014.05.132 ◽

2014 ◽

Vol 136 ◽

pp. 377-384 ◽

Cited By ~ 6

Author(s):

Jing Li ◽

Fengli Gao ◽

Enbo Shangguan ◽

Quanmin Li

Keyword(s):

Hydrogen Bond ◽

Uric Acid ◽

Reduction Reaction ◽

Auxiliary Electrode ◽

Oxidation Peak ◽

Influencing Mechanism

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Reduced Graphene Oxide Fibre Electrodes for Drug Sensing

Proceedings ◽

10.3390/proceedings2021068018 ◽

2021 ◽

Vol 68 (1) ◽

pp. 18

Author(s):

Sutthima Sriprasertsuk ◽

John R. Varcoe ◽

Carol Crean

Keyword(s):

Cyclic Voltammetry ◽

Graphene Oxide ◽

Carbon Fibre ◽

Reduced Graphene Oxide ◽

Limit Of Detection ◽

Linear Range ◽

Oxidation Peak ◽

Reduced Graphene ◽

Fibre Sensor ◽

Model Drug

Reduced graphene oxide (rGO) fibre electrodes and their ability to sense paracetamol (as model drug) were studied. rGO was electrodeposited onto carbon fibre by two different approaches: potentiostatic deposition and cyclic voltammetry (CV) in the presence of graphene oxide solution. Carbon fibre electrodes coated with rGO (after five CV cycles) could sense paracetamol with an oxidation peak at 0.62 V (vs. Ag/AgCl). The limit of detection of this fibre sensor was found to be 36.3 µM with a linear range of 50–500 µM of paracetamol (R2 = 0.9901).

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Interference of ascorbic acid with chemical analytes

Annals of Clinical Biochemistry International Journal of Laboratory Medicine ◽

10.1258/000456305774538274 ◽

2005 ◽

Vol 42 (6) ◽

pp. 475-477 ◽

Cited By ~ 15

Author(s):

Qing H Meng ◽

William C Irwin ◽

Jennifer Fesser ◽

K Lorne Massey

Keyword(s):

Ascorbic Acid ◽

Creatine Kinase ◽

Uric Acid ◽

Total Cholesterol ◽

Acid Concentration ◽

Total Bilirubin ◽

Binding Capacity ◽

Ascorbic Acid Concentration ◽

Sodium Potassium ◽

Creatine Kinase Mb

Background: Ascorbic acid can interfere with methodologies involving redox reactions, while comprehensive studies on main chemistry analysers have not been reported. We therefore attempted to determine the interference of ascorbic acid with analytes on the Beckman Synchron LX20®. Methods: Various concentrations of ascorbic acid were added to serum, and the serum analytes were measured on the LX20. Results: With a serum ascorbic acid concentration of 12.0 mmol/L, the values for sodium, potassium, calcium and creatinine increased by 43%, 58%, 103% and 26%, respectively ( P<0.01). With a serum ascorbic acid concentration of 12.0 mmol/L, the values for chloride, total bilirubin and uric acid decreased by 33%, 62% and 83%, respectively ( P<0.01), and were undetectable for total cholesterol, triglyceride, ammonia and lactate. There was no definite influence of ascorbic acid on analytical values for total CO2, urea, glucose, phosphate, total protein, albumin, amylase, creatine kinase, creatine kinase-MB, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total iron, unbound iron-binding capacity or magnesium. Conclusions: Ascorbic acid causes a false increase in sodium, potassium, calcium and creatinine results and a false decrease in chloride, total bilirubin, uric acid, total cholesterol, triglyceride, ammonia and lactate results.

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