scholarly journals Reduced Graphene Oxide Fibre Electrodes for Drug Sensing

Proceedings ◽  
2021 ◽  
Vol 68 (1) ◽  
pp. 18
Author(s):  
Sutthima Sriprasertsuk ◽  
John R. Varcoe ◽  
Carol Crean
Keyword(s):  
Cyclic Voltammetry ◽  
Graphene Oxide ◽  
Carbon Fibre ◽  
Reduced Graphene Oxide ◽  
Limit Of Detection ◽  
Linear Range ◽  
Oxidation Peak ◽  
Reduced Graphene ◽  
Fibre Sensor ◽  
Model Drug

Reduced graphene oxide (rGO) fibre electrodes and their ability to sense paracetamol (as model drug) were studied. rGO was electrodeposited onto carbon fibre by two different approaches: potentiostatic deposition and cyclic voltammetry (CV) in the presence of graphene oxide solution. Carbon fibre electrodes coated with rGO (after five CV cycles) could sense paracetamol with an oxidation peak at 0.62 V (vs. Ag/AgCl). The limit of detection of this fibre sensor was found to be 36.3 µM with a linear range of 50–500 µM of paracetamol (R2 = 0.9901).

scholarly journals Polypyrrole Fibre Electrodes for Drug Sensing

Proceedings ◽  
2020 ◽  
Vol 32 (1) ◽  
pp. 20 ◽  
Author(s):  
Sutthima Sriprasertsuk ◽  
John R. Varcoe ◽  
Carol Crean
Keyword(s):  
Ascorbic Acid ◽  
Cyclic Voltammetry ◽  
Sodium Dodecyl Sulfate ◽  
Carbon Fibre ◽  
Limit Of Detection ◽  
Sodium Dodecyl ◽  
Potassium Nitrate ◽  
Oxidation Peak ◽  
Fibre Sensor ◽  
Model Drug

Polypyrrole (PPy) fibre electrodes and their ability to sense paracetamol (as a model drug) in addition to interferents such as ascorbic acid and dopamine were studied. PPy was electrodeposited onto carbon fibre (CF) through electropolymerisation using cyclic voltammetry in the presence of two different counter anions: potassium nitrate (KNO3) and sodium dodecyl sulfate (SDS). PPy with SDS as dopant could sense paracetamol with an oxidation peak at 0.55 V vs. Ag/AgCl. The limit of detection of this fibre sensor was found to be 1 µM with a linear range of 1–100 µM of paracetamol (R2 = 0.985).

scholarly journals A label-free biosensor based on graphene and reduced graphene oxide dual-layer for electrochemical determination of beta-amyloid biomarkers

2020 ◽  
Vol 187 (5) ◽  
Author(s):  
Jagriti Sethi ◽  
Michiel Van Bulck ◽  
Ahmed Suhail ◽  
Mina Safarzadeh ◽  
Ana Perez-Castillo ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Limit Of Detection ◽  
Electrochemical Techniques ◽  
Differential Pulse ◽  
Electrochemical Determination ◽  
Label Free ◽  
Reduced Graphene ◽  
Electrochemically Reduced Graphene Oxide

AbstractA label-free biosensor is developed for the determination of plasma-based Aβ1–42 biomarker in Alzheimer’s disease (AD). The platform is based on highly conductive dual-layer of graphene and electrochemically reduced graphene oxide (rGO). The modification of dual-layer with 1-pyrenebutyric acid N-hydroxysuccinimide ester (Pyr-NHS) is achieved to facilitate immobilization of H31L21 antibody. The effect of these modifications were studied with morphological, spectral and electrochemical techniques. The response of the biosensor was evaluated using differential pulse voltammetry (DPV). The data was acquired at a working potential of ~ 180 mV and a scan rate of 50 mV s−1. A low limit of detection (LOD) of 2.398 pM is achieved over a wide linear range from 11 pM to 55 nM. The biosensor exhibits excellent specificity over Aβ1–40 and ApoE ε4 interfering species. Thus, it provides a viable tool for electrochemical determination of Aβ1–42. Spiked human and mice plasmas were used for the successful validation of the sensing platform in bio-fluidic samples. The results obtained from mice plasma analysis concurred with the immunohistochemistry (IHC) and magnetic resonance imaging (MRI) data obtained from brain analysis.

scholarly journals Electrocatalysis of Ethanol and Methanol Electrooxidation by Composite Electrodes with NiOOH/FeOOH Supported on Reduced Graphene Oxide onto Composite Electrodes

2020 ◽  
Vol 2 (1) ◽  
pp. 2
Author(s):  
João Pedro Jenson de Oliveira ◽  
Acelino Cardoso de Sá ◽  
Leonardo Lataro Paim
Keyword(s):  
Cyclic Voltammetry ◽  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Alkaline Medium ◽  
Methanol Electrooxidation ◽  
Potential Range ◽  
Composite Electrodes ◽  
Reduced Graphene ◽  
Iron Nickel ◽  
Nickel Oxyhydroxide

This paper presents graphite/paraffin composite electrodes modified with microparticles of nickel (Ni) and Ni-Fe alloy anchored in reduced graphene oxide (rGO); these electrodes were made by electrosynthesis. Firstly, the electrodeposition of reduced graphene oxide was made by cyclic voltammetry (CV) onto the graphite/paraffin electrodes’ surface. After electrodeposition of the rGO, iron and nickel were electrodeposited by CV with successive scans. Finally, the formation of iron-nickel oxyhydroxide on the electrode surface was performed by cyclic voltammetry in alkaline medium. The composites were investigated by field emission gun scanning electron microscopy (FEG-SEM); it was observed that the Ni microparticles had spherical shapes, while the Ni-Fe alloy did not present a defined shape. The composite electrodes were used to analysis ethanol and methanol electrooxidation in an alkaline medium of 0.10 mol L−1 of NaOH in a potential range of from −0.20 to 1.0 V (vs. Ag/AgCl) at 50 mV s−1 by CV. The electrodes were able to make the electrooxidation of ethanol at a potential of around 0.57 V for the electrode constituted by the Ni-Fe alloy and around 0.61 V for the electrode modified with Ni, and for methanol in a potential around 0.57 V for the Ni-Fe alloy and around 0.66 V for the Ni electrode. The Ni-Fe alloy electrodes showed the electrocatalysis of the alcohols in relation to Ni electrodes.

scholarly journals Reduced Graphene Oxide Carbon Yarn Electrodes for Drug Sensing

2021 ◽  
Vol 2 ◽  
Author(s):  
Sutthima Sriprasertsuk ◽  
Shuai Zhang ◽  
Gordon Wallace ◽  
Jun Chen ◽  
John R. Varcoe ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Detection Limit ◽  
Carbon Fibre ◽  
Reduced Graphene Oxide ◽  
Simultaneous Detection ◽  
Differential Pulse ◽  
Reduced Graphene ◽  
Electrochemically Deposited ◽  
Pulse Voltammetry

A modified carbon fibre yarn sensor was developed for the voltammetric determination of paracetamol and its interferents (dopamine and ascorbic acid). Reduced graphene oxide (rGO) was electrochemically deposited onto a carbon fibre yarn. Further modification was achieved using polypyrrole (PPy) coated onto the rGO carbon fibre yarn via electropolymerisation of pyrrole with cyclic voltammetry (CV). The surface of the rGO and PPy-rGO carbon fibre electrodes were characterised using Raman spectroscopy and scanning electron microscopy. The rGO and PPy-rGO carbon fibres had a 3.5-fold and 7-fold larger electrochemical surface area compared to bare carbon fibre (calculated using the Randles-Sevcik equation). Two clearly distinguished oxidation peaks at 0.49 and 0.25 V (vs. Ag/AgCl) were observed at the rGO fibre electrode during the simultaneous detection of paracetamol and dopamine, respectively, by CV. The detection limit (3σ S/N) of the rGO carbon fibre electrode for differential pulse voltammetry (DPV) determination of paracetamol was at 21.1 and 6.0 µM for dopamine. In comparison, the simultaneous determination of paracetamol and dopamine by CV at the PPy-rGO fibre electrode gave oxidation peaks of paracetamol and dopamine at 0.55 and 0.25 V (vs. Ag/AgCl), respectively. The detection limit (3σ S/N) for paracetamol was notably improved to 3.7 µM and maintained at 6.0 µM for dopamine at the PPy-rGO carbon fibre electrode during DPV.

scholarly journals An electrodeposited molecularly imprinted quartz crystal microbalance sensor sensitized with AuNPs and rGO material for highly selective and sensitive detection of amantadine

RSC Advances ◽  
2018 ◽  
Vol 8 (12) ◽  
pp. 6600-6607 ◽  
Author(s):  
Yaguang Yun ◽  
Mingfei Pan ◽  
Guozhen Fang ◽  
Ying Gu ◽  
Wenjun Wen ◽  
...  
Keyword(s):  
Cyclic Voltammetry ◽  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Quartz Crystal Microbalance ◽  
Quartz Crystal ◽  
Au Nanoparticles ◽  
Oxide Material ◽  
Molecularly Imprinted ◽  
Quartz Crystal Microbalance Sensor ◽  
Reduced Graphene

In the present work, a new amantadine imprinted quartz crystal microbalance sensor sensitized by Au nanoparticles and reduced graphene oxide material was fabricated by electrodeposition of o-aminothiophenol by cyclic voltammetry scanning.

scholarly journals SIMULTANEOUS ELECTROCHEMICAL DETECTION OF ASCORBIC ACID, DOPAMINE, AND URIC ACID AT MAGNETIC NANOPARTICLES/REDUCED GRAPHENE OXIDE MODIFIED ELECTRODE

2021 ◽  
Vol 83 (3) ◽  
pp. 85-92
Author(s):  
Azleen Rashidah Mohd Rosli ◽  
Farhanini Yusoff ◽  
Saw Hong Loh ◽  
Hanis Mohd Yusoff ◽  
Muhammad Mahadi Abdul Jamil ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Uric Acid ◽  
Graphene Oxide ◽  
Magnetic Nanoparticles ◽  
Reduced Graphene Oxide ◽  
Modified Electrode ◽  
Limit Of Detection ◽  
Simultaneous Detection ◽  
Differential Pulse ◽  
Reduced Graphene

A magnetic nanoparticles/reduced graphene oxide modified glassy carbon electrode (MNP/rGO/GCE) was fabricated via one-step facile synthesis route for the simultaneous determination of ascorbic acid (AA), dopamine (DA), along with uric acid (UA). A series of diseases and disorders has been associated with irregular levels of these respective analytes, thus early detection is highly crucial. Physical and electrochemical characterization of the modified electrode was conducted by using Scanning Electron Microscopy (SEM), Fourier Transform Infrared (FTIR) analysis, X-Ray Diffraction (XRD) analysis and Brauneur-Emmet-Teller (BET), Cyclic Voltammetry (CV) and Electron Impedance Spectroscopy (EIS). The results obtained confirmed the formation of MNP/rGO composite. Differential pulse voltammetry (DPV) of MNP/rGO/GCE displays three well-defined peaks which associated to AA, DA and UA, respectively. The response towards DA is linear in the concentration range of 15 nM to 100 µM with a detection limit of 0.19 nM while a response to AA and UA is also linear in the concentration range of 10 µM to 100 µM with a limit of detection 0.22 µM and 45 nM respectively. The proposed modified electrode offers a good response towards simultaneous detection of three different electroactive species with excellent electron transfer rate, great capacitance and ideal diffusive control behavior.

Reduced Graphene Oxide/Multiwalled Carbon Nanotube Composite Decorated with Fe3O4 Magnetic Nanoparticles for Electrochemical Determination of Hydrazine in Environmental Water

2020 ◽  
Vol 20 (5) ◽  
pp. 3148-3156 ◽  
Author(s):  
S. Nehru ◽  
Subramanian Sakthinathan ◽  
P. Tamizhdurai ◽  
Te-Wei Chiu ◽  
K. Shanthi
Keyword(s):  
Graphene Oxide ◽  
Carbon Nanotube ◽  
Magnetic Nanoparticles ◽  
Reduced Graphene Oxide ◽  
Electrochemical Impedance ◽  
Limit Of Detection ◽  
High Sensitivity ◽  
Multiwalled Carbon Nanotube ◽  
Multiwalled Carbon ◽  
Reduced Graphene

In the present work, a reduced graphene oxide and multiwalled carbon nanotube (RGO/MWCNTFe3O4) composite decorated with Fe3O4 magnetic nanoparticles was prepared as an electrochemical sensor. The surface morphology of the prepared composite was identified by scanning electron microscopy and X-ray diffraction. The electrochemical properties of the GCE/RGO/MWCNT-Fe3O4 electrode were investigated by electrochemical impedance spectroscopy, cyclic voltammetry and amperometry. The GCE/RGO/MWCNT-Fe3O4 electrode exhibited higher electrocatalytic performance towards the oxidation of hydrazine. In the optimal conditions, the GCE/RGO/MWCNT-Fe3O4 electrode showed a wide linear range (0.15–220 μM), low limit of detection (LOD) (0.75 μM), and high sensitivity (2.868 μA μM−1 cm−2). The prepared GCE/RGO/MWCNT-Fe3O4 electrode also had excellent repeatability, selectivity, and reproducibility. The practical application of the electrode was confirmed with various spiked water samples and demonstrated acceptable recovery.

scholarly journals Label-Free DNA Biosensor Using Modified Reduced Graphene Oxide Platform as a DNA Methylation Assay

Materials ◽  
2020 ◽  
Vol 13 (21) ◽  
pp. 4936 ◽  
Author(s):  
Eliska Sedlackova ◽  
Zuzana Bytesnikova ◽  
Eliska Birgusova ◽  
Pavel Svec ◽  
Amir M. Ashrafi ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Limit Of Detection ◽  
Differential Pulse ◽  
Clinical Diagnostics ◽  
Label Free ◽  
Free Dna ◽  
Methylation Assay ◽  
Reduced Graphene

This work reports the use of modified reduced graphene oxide (rGO) as a platform for a label-free DNA-based electrochemical biosensor as a possible diagnostic tool for a DNA methylation assay. The biosensor sensitivity was enhanced by variously modified rGO. The rGO decorated with three nanoparticles (NPs)—gold (AuNPs), silver (AgNPs), and copper (CuNPs)—was implemented to increase the electrode surface area. Subsequently, the thiolated DNA probe (single-stranded DNA, ssDNA−1) was hybridized with the target DNA sequence (ssDNA-2). After the hybridization, the double-stranded DNA (dsDNA) was methylated by M.SssI methyltransferase (MTase) and then digested via a HpaII endonuclease specific site sequence of CpG (5′-CCGG-3′) islands. For monitoring the MTase activity, differential pulse voltammetry (DPV) was used, whereas the best results were obtained by rGO-AuNPs. This assay is rapid, cost-effective, sensitive, selective, highly specific, and displays a low limit of detection (LOD) of 0.06 U·mL−1. Lastly, this study was enriched with the real serum sample, where a 0.19 U·mL−1 LOD was achieved. Moreover, the developed biosensor offers excellent potential in future applications in clinical diagnostics, as this approach can be used in the design of other biosensors.

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