scholarly journals Polypyrrole Fibre Electrodes for Drug Sensing

Proceedings ◽  
2020 ◽  
Vol 32 (1) ◽  
pp. 20 ◽  
Author(s):  
Sutthima Sriprasertsuk ◽  
John R. Varcoe ◽  
Carol Crean
Keyword(s):  
Ascorbic Acid ◽  
Cyclic Voltammetry ◽  
Sodium Dodecyl Sulfate ◽  
Carbon Fibre ◽  
Limit Of Detection ◽  
Sodium Dodecyl ◽  
Potassium Nitrate ◽  
Oxidation Peak ◽  
Fibre Sensor ◽  
Model Drug

Polypyrrole (PPy) fibre electrodes and their ability to sense paracetamol (as a model drug) in addition to interferents such as ascorbic acid and dopamine were studied. PPy was electrodeposited onto carbon fibre (CF) through electropolymerisation using cyclic voltammetry in the presence of two different counter anions: potassium nitrate (KNO3) and sodium dodecyl sulfate (SDS). PPy with SDS as dopant could sense paracetamol with an oxidation peak at 0.55 V vs. Ag/AgCl. The limit of detection of this fibre sensor was found to be 1 µM with a linear range of 1–100 µM of paracetamol (R2 = 0.985).

scholarly journals Reduced Graphene Oxide Fibre Electrodes for Drug Sensing

Proceedings ◽  
2021 ◽  
Vol 68 (1) ◽  
pp. 18
Author(s):  
Sutthima Sriprasertsuk ◽  
John R. Varcoe ◽  
Carol Crean
Keyword(s):  
Cyclic Voltammetry ◽  
Graphene Oxide ◽  
Carbon Fibre ◽  
Reduced Graphene Oxide ◽  
Limit Of Detection ◽  
Linear Range ◽  
Oxidation Peak ◽  
Reduced Graphene ◽  
Fibre Sensor ◽  
Model Drug

Reduced graphene oxide (rGO) fibre electrodes and their ability to sense paracetamol (as model drug) were studied. rGO was electrodeposited onto carbon fibre by two different approaches: potentiostatic deposition and cyclic voltammetry (CV) in the presence of graphene oxide solution. Carbon fibre electrodes coated with rGO (after five CV cycles) could sense paracetamol with an oxidation peak at 0.62 V (vs. Ag/AgCl). The limit of detection of this fibre sensor was found to be 36.3 µM with a linear range of 50–500 µM of paracetamol (R2 = 0.9901).

scholarly journals Determination of Simvastatin by Voltammetry Method at Screen-Printed Electrode Modified by Graphene Oxide Nanosheets and Sodium Dodecyl Sulfate

2022 ◽  
Author(s):  
Abolfazl Darroudi ◽  
Saeid Nazari ◽  
Seyed Ali Marashi ◽  
Mahdi Karimi-Nazarabad
Keyword(s):  
Graphene Oxide ◽  
Sodium Dodecyl Sulfate ◽  
Limit Of Detection ◽  
Sodium Dodecyl ◽  
Screen Printed Electrode ◽  
Support Electrolyte ◽  
Limit Of Quantitation ◽  
Dodecyl Sulfate ◽  
Screen Printed

Abstract An accurate, rapid, simple, and novel technique was developed to determine simvastatin (SMV). In this research, a screen-printed electrode (SPE) was deposited with graphene oxide (GO) and sodium dodecyl sulfate (SDS), respectively. For the first time, the handmade modified SPE measured the SMV by differential pulse voltammetry (DPV) with high sensitivity and selectivity. The results of cyclic voltammetry indicated the oxidation irreversible process of SMV. Various parameters (pH, concentration, scan rate, support electrolyte) were performed to optimize the conditions for the determination of SMV. Under the optimum experiment condition of 0.1 M KNO3 as support electrolyte and pH 7.0, the linear range was achieved for SMV concentration from 1.8 to 36.6 µM with a limit of detection (LOD), and a limit of quantitation (LOQ) of 0.06 and 1.8 µM, respectively. The proposed method was successfully utilized to determine SMV in tablets and urine samples with a satisfactory recovery in the range of 96.2 to 103.3%.

scholarly journals An Electrochemical Sensor Based On Graphite Electrode Modified With Silica Containing 1-N-Propyl-3-Methylimidazolium Species For Determination Of Ascorbic Acid

2019 ◽  
Vol Vol. 14, No.1 ◽  
pp. 5-14 ◽  
Author(s):  
Anastasiya Tkachenko ◽  
Mykyta Onizhuk ◽  
Oleg Tkachenko ◽  
Leliz T. Arenas ◽  
Edilson V. Benvenutt ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Cyclic Voltammetry ◽  
Electrochemical Sensor ◽  
Electrochemical Impedance ◽  
Limit Of Detection ◽  
Pharmaceutical Formulations ◽  
Differential Pulse ◽  
Long Term Stability ◽  
Diffusion Limited

In the present study, an electrochemical sensor based on the electrode (SiMImCl/C) consisting of graphite and silica, grafted with 1-n-propyl-3-methylimidazolium chloride was used for ascorbic acid (AA) quantification in pharmaceuticals and food formulations. Cyclic voltammetry and electrochemical impedance spectroscopy were applied for electrochemical characterization of the SiMImCl/C electrode. The cyclic voltammetry study revealed that the oxidation of AA on this electrode is an irreversible process, realized by adsorption and diffusion limited step. The differential pulse voltammetry was applied to develop a procedure for the AA determination. The linear range was found to be 0.3–170 μmol L-1 and the limit of detection – 0.1 μmol L-1. The proposed SiMImCl/C electrode has long term stability and does not show electrochemical activity towards the analytes, which commonly coexist with AA. The sensor was successfully used for quantification of AA in food and pharmaceutical formulations.

Sensitive, Direct Procedures for Simultaneous Determinations of Iron and Copper in Serum, with Use of 2-(5-Nitro-2-Pyridylazo)-5-(N-Propyl-N-Sulfopropylamino)Phenol (Nitro-PAPS) as Ligand

1992 ◽  
Vol 38 (7) ◽  
pp. 1373-1375 ◽  
Author(s):  
S Yamashita ◽  
A Abe ◽  
A Noma
Keyword(s):  
Ascorbic Acid ◽  
Sodium Dodecyl Sulfate ◽  
Present Method ◽  
Thioglycolic Acid ◽  
Colorimetric Assay ◽  
Spectroscopic Method ◽  
Sodium Dodecyl ◽  
Disodium Salt ◽  
Water Soluble ◽  
Regression Analyses

Abstract We developed a direct, simple, and sensitive procedure for the simultaneous colorimetric assay of iron and copper in serum, using sodium dodecyl sulfate-ascorbic acid to dissociate iron and copper from transferrin and ceruloplasmin, respectively. We also use a new water-soluble reagent, 2-(5-nitro-2-pyridylazo)-5-(N-propyl-N-sulfopropylamino)phenol disodium salt (nitro-PAPS) and thioglycolic acid to eliminate interference from copper in the measurement of iron. Within- and between-run precisions of the present method were 2.5-2.8% for iron and 1.8-4.6% for copper. The proposed method is susceptible to interference by hemoglobin and lipemia, especially for the iron assay. Linear-regression analyses of results of the proposed method with those of the bathophenanthroline method for iron and of the atomic absorption spectroscopic method for copper correlated well (r = 0.996, Sy/x = 0.73 and r = 0.959, Sy/x = 1.11, respectively).

Self-Assembly of α-MnO2 Nanorods into Spheres: Synthesis and Electrochemical Properties

2008 ◽  
Vol 8 (3) ◽  
pp. 1494-1496 ◽  
Author(s):  
Xu Chun Song ◽  
Yi Fan Zheng ◽  
E. Yang ◽  
Yun Wang
Keyword(s):  
Cyclic Voltammetry ◽  
Sodium Dodecyl Sulfate ◽  
Electrochemical Properties ◽  
Electrode Material ◽  
Self Assembly ◽  
Sodium Dodecyl ◽  
Electrochemical Characterization ◽  
Dodecyl Sulfate ◽  
Hydrothermal Approach

The α-MnO2 spherical assemblies were prepared via a facile hydrothermal approach in the presence of sodium dodecyl sulfate (SDS). The assembled nanostructures were composed of the MnO2 nanorods with 150–200 nm in width and several micrometers in length. The products were characterized by SEM, TEM and XRD. The electrochemical characterization was carried out by cyclic voltammetry, which indicated that the α-MnO2 spherical assemblies were of an excellent electrode material for supercapacitor.

scholarly journals Electrochemical detection of ascorbic acid in artificial sweat using a flexible alginate/CuO-modified electrode

2020 ◽  
Vol 187 (9) ◽  
Author(s):  
Bergoi Ibarlucea ◽  
Arnau Pérez Roig ◽  
Dmitry Belyaev ◽  
Larysa Baraban ◽  
Gianaurelio Cuniberti
Keyword(s):  
Ascorbic Acid ◽  
Cyclic Voltammetry ◽  
Electrochemical Detection ◽  
Limit Of Detection ◽  
Low Cost ◽  
Reference Electrode ◽  
Single Step ◽  
Repeated Measurements ◽  
Relative Standard ◽  
Artificial Sweat

Abstract A flexible sensor is presented for electrochemical detection of ascorbic acid in sweat based on single-step modified gold microelectrodes. The modification consists of electrodeposition of alginate membrane with trapped CuO nanoparticles. The electrodes are fabricated at a thin polyimide support and the soft nature of the membrane can withstand mechanical stress beyond requirements for skin monitoring. After characterization of the membrane via optical and scanning electron microscopy and cyclic voltammetry, the oxidative properties of CuO are exploited toward ascorbic acid for amperometric measurement at micromolar levels in neutral buffer and acidic artificial sweat, at ultralow applied potential (− 5 mV vs. Au pseudo-reference electrode). Alternatively, measurement of the horizontal shift of redox peaks by cyclic voltammetry is also possible. Obtaining a limit of detection of 1.97 μM, sensitivity of 0.103 V log (μM)−1 of peak shift, and linear range of 10–150 μM, the effect of possible interfering species present in sweat is minimized, with no observable cross-reaction, thus maintaining a high degree of selectivity despite the absence of enzymes in the fabrication scheme. With a lateral flow approach for sample delivery, repeated measurements show recovery in few seconds, with relative standard deviation of about 20%, which can serve to detect increased loss or absence of vitamin, and yet be improved in future by optimized device designs. This sensor is envisioned as a promising component of wearable devices for e.g. non-invasive monitoring of micronutrient loss through sweat, comprising features of light weight, low cost, and easy fabrication needed for such application.

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